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Aerosol technology is a promising platform to synthesize and study core-shellnanoparticles - a multi-elemental nanoparticle system where the core of one material is covered by a shell of another material. In this thesis, two distinctly separate strategies have been explored to synthesize core-shell nanoparticles by aerosol methods: physical vapor deposition (PVD) by evaporation, and surface segreg
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the effects of different regimens of systemic opioid analgesics in neonates (term or preterm) undergoing surgery, on mortality, pain and major neurodevelopmental disability. These different regimens may include: different doses of the same opioid; different routes of administration of
III-V semiconductor nanowires are high aspect ratio nanostructures with superior properties that can potentially enhance the functionality of next-generation opto-electronic devices. At present, the most reliable method for fabricating III-V semiconductor nanowires is the particle-assisted vapor-liquid-solid growth using a substrate-based growth process. However, a substrate-based process limits t
Hybrid superconductor-semiconductor heterostructures are promising platforms for realizing topological superconductors and exploring Majorana bound state physics. Motivated by recent experimental progress, we theoretically study how magnetic insulators offer an alternative to the use of external magnetic fields for reaching the topological regime. We consider different setups, where (1) the magnet
Ferroelectric memories based on hafnium oxide are an attractive alternative to conventional memory technologies due to their scalability and energy efficiency. However, there are still many open questions regarding the optimal material stack and processing conditions for reliable device performance. Here, we report on the impact of the sputtering process conditions of the commonly used TiN top ele
Organisms use circadian rhythms to anticipate and exploit daily environmental oscillations. While circadian rhythms are of clear importance for inhabitants of tropic and temperate latitudes, its role for permanent residents of the polar regions is less well understood. The high Arctic Svalbard ptarmigan shows behavioral rhythmicity in presence of light-dark cycles but is arrhythmic during the pola
Recent outlooks suggest a long-term relevance of internal combustion engines for both power generation and transportation. Nonetheless, stringent pollutant reduction requirements combined with new CO2 mandates draws a challenging scenario, requiring intensive research and development activities to develop and optimize combustion modes to fulfill these requirements. Among the recent advancements, t
Quantum dot based parity-to-charge conversion is a promising method for reading out quantum information encoded nonlocally into pairs of Majorana zero modes. To obtain a sizable parity-to-charge visibility, it is crucial to tune the relative phase of the tunnel couplings between the dot and the Majorana modes appropriately. However, in the presence of multiple quasidegenerate dot orbitals, it is i
Molecular motor gliding motility assays based on myosin/actin or kinesin/microtubules are of interest for nanotechnology applications ranging from cargo-trafficking in lab-on-a-chip devices to novel biocomputation strategies. Prototype systems are typically monitored by expensive and bulky fluorescence microscopy systems. The development of integrated, direct electric detection of single filaments
Objective: The purpose of this study was to clarify the mediational pathways from genetic risk for alcohol use disorder (AUD) to AUD itself. Method: Using information on AUD status from first-through fourth-degree relatives obtained from national registries, we created a genetic risk score for AUD for the Swedish population. We first tested a simple mediational path model in males and females sepa
Aim: We aimed to estimate the risk of hearing impairment in children and adolescents with foreign-born parents, compared to natives. Methods: A nationwide study of 1,923,590 (51.4% boys) individuals aged 0–17 years of age in Sweden. Hearing impairment was defined as at least one registered diagnosis in the National Patient Register between 1 January 1998 and 31 December 2015. We used Cox regressio
The aim of this thesis is to study early life risk exposures in relation to adult health and mortality in Sweden during 250 years. A number of causal mechanisms by which exposure to diseases and stressful economic and social conditions early in life may lead to increased morbidity and mortality later in life are discussed (paper I). The early life exposures investigated are the foetal origins (nut
Abstract OBJECTIVES: To investigate the effects of antenatal betamethasone on fetal and uteroplacental hemodynamics. METHODS: The study comprised 33 women with singleton high-risk pregnancies (23-33 weeks; 27 pregnancies < 30 weeks) not in labor, but at risk for preterm delivery based on fetal or maternal indications. They were treated with two doses of 12 mg betamethasone intramuscularly 24 h ap
Obese patients are prone to arterial hypertension, require more antihypertensive medications, and have an increased risk of treatment-resistant arterial hypertension. Obesity-induced neurohumoral activation appears to be involved. The association between obesity and hypertension shows large inter-individual variability, likely through genetic mechanisms. Obesity affects overall cardiovascular and
Substitution of carbohydrates with fat in a diet for type 2 diabetes patients is still debated.
Stroke is the third most common cause of death in developed countries, exceeded only by coronary heart disease and cancer, but there is still little knowledge on occupational risk factors. A systematic critical review was performed to assess the strength of evidence for causal associations between work-related psychosocial risk factors, shift work and stroke.
High dietary salt is a leading risk for death and disability largely by causing increased blood pressure. Other associated health risks include gastric and renal cell cancers, osteoporosis, renal stones, and increased disease activity in multiple sclerosis, headache, increased body fat and Meniere's disease. The World Hypertension League (WHL) has prioritized advocacy for salt reduction. WHL resou
Simple measures of type I interferon (IFN) activity constitute highly attractive biomarkers in systemic lupus erythematosus (SLE). We explore galectin-3-binding protein (G3BP) as a novel measure of type I IFN activity and serum/plasma biomarker in large independent cohorts of patients with SLE and controls.
To assess burden in the caregivers of patients with severe traumatic brain injury (TBI) 1 year postinjury, related to caregiver's demographic data and social network, patient's demographic data, injury severity, and functional status.
