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Galectin-3 is extensively involved in metabolic and disease processes, such as cancer metastasis, thus giving impetus for the design of specific inhibitors targeting this -galactose-binding protein. Thiodigalactoside (TDG) presents a scaffold for construction of galectin inhibitors, and its inhibition of galectin-1 has already demonstrated beneficial effects as an adjuvant with vaccine immunothera
A new read-out method for antibody arrays using laser desorption/ionization-mass spectrometry (LDI-MS) is presented. Small, photocleavable reporter molecules with a defined mass called "mass-tags" are used for detection of immunocaptured proteins from human plasma. Using prostate specific antigen (PSA), a biomarker for prostate cancer, as a model antigen, a high sensitivity generic detection metho
In this paper, an inverse source reconstruction method with great potential in radome diagnostics is presented. Defects, e.g., seams in large radomes, and lattice dislocations in frequency selective surface (FSS) radomes, are inevitable, and their electrical effects demand analysis. Here, defects in a frequency selective radome are analyzed with a method based on an integral formulation. Several f
To describe the relatives' experiences of information and support while heart or lung transplant candidates were waiting for a transplantation.
BACKGROUND: A most important characteristic feature for poor prognosis in colorectal cancer (CRC) is the presence of lymph node metastasis. Determination of carcinoembryonic antigen (CEA) mRNA levels in lymph nodes has proven powerful for quantification of disseminated tumour cells. Here, we investigate the utility of human tissue kallikrein-related peptidase 6 (KLK6) mRNA as a progression biomark
The Matern covariance function is a popular choice for modeling dependence in spatial environmental data. Standard Matern covariance models are, however, often computationally infeasible for large data sets. Recent results for Markov approximations of Gaussian Matern fields based on Hilbert space approximations are extended using wavelet basis functions. Using a simulation-based study, these Marko
Previous studies have shown that fossil energy systems can be a conflict objective, means or cause. This study explores how renewable energy (RE) systems can interact with conflicts and to what extent the risk of different conflicts may change. Renewable resources, in contrast to conventional fossil resources, are more difficult to control in time and space. RE systems depend on exploiting flows r
In this paper, we introduce a scale of differential operators which is shown to correspond canonically to a certain scale of solution kernels generalizing the classical Poisson kernel for the unit disc. The scale of kernels studied is very natural and appears in many places in mathematical analysis, such as in the theory of integral representations of biharmonic functions in the unit disc.
Abstract in UndeterminedThe present paper describes how the control of a radiator system connected to a district heating (DH) network via a heat exchanger can be optimized to provide the lowest possible DH return temperature. This can be achieved for each operating point by employing an optimal combination of radiator circuit supply temperature and circulation flow rate. The control algorithm grad
The synthesis of four molybdenum and tungsten complexes bearing tetradentate tripodal amino bisphenolate ligands with either hydroxyethylene (1a) or hydroxyglycolene (1b) substituents is reported. The molybdenum dioxo complexes [MoO2L] (L = 2a, 2b) and tungsten complexes [WO2L] (3a, 3b) were synthesized using [MoO2(acac)(2)] and [W(eg)(3)] (eg = 1,2-ethanediolato, ethylene glycolate), respectively
Analysis of multivariate data sets from, for example, microarray studies frequently results in lists of genes which are associated with some response of interest. The biological interpretation is often complicated by the statistical instability of the obtained gene lists, which may partly be due to the functional redundancy among genes, implying that multiple genes can play exchangeable roles in t
It is of highest importance to find proteins responsible for breast cancer dissemination, for use as biomarkers or treatment targets. We established and performed a combined nontargeted LC MS/MS and a targeted LC SRM workflow for discovery and validation of protein biomarkers. Eighty breast tumors, stratified for estrogen receptor status and development of distant recurrence (DR +/-), were collect
This review will discuss methodologies and applicability of key inflammatory models of respiratory disease in proof of concept or proof of efficacy clinical studies. In close relationship with these models, induced sputum and inflammatory cell counts will be addressed for phenotype-directed drug development. Additionally, important regulatory aspects regarding noninvestigational medicinal products
Background Therapeutic drug monitoring (TDM) of antibiotics in children is of fundamental importance for effective patient management. The use of dried blood spot (DBS) offers a number of advantages over conventional blood collection. The aim of this study is to develop and validate a method to measure piperacillin/tazobactam in DBS. Results The analysis was performed by using LC-MS/MS operating i
Energy-rich methane can be harnessed from seaweed deposits by anaerobic digestion. However, the high heavy metal content in the seaweed and its digestates limits their use as fertilisers. Heavy metal contaminants from solid seaweed can be removed by, mobilisation into a liquid phase and subsequent metal ions adsorption. In this laboratory-scale study, pretreatment strategies for enhancing seaweed
This work compares the extent of linear response regimes from standard time-resolving optical detectors for phosphor thermometry. Different types of Photomultipliers (ordinary and time-gated) as well as an Avalanche Photodiode are tested and compared using the phosphorescent time decay of CdWO4 that ranges from 10 mu s down to a few ns within a temperature span of 290 to 580 K. Effects originating
The rotation of water in noble gas matrices has been studied. It is shown that the rotation-translation coupling model of Friedmann and Kimel predicts rotation line spacings, which are close to the experimental observations for H2O, D2O, and HDO, when gas phase rotation constants are used. The model gives intensity estimates in reasonable agreement with the observations for the local oscillator ba
The Vel antigen is present on red blood cells (RBCs) from all humans except rare Vel-negative individuals who can form antibodies to Vel in response to transfusion or pregnancy. These antibodies may cause severe hemolytic reactions in blood recipients. We combined SNP profiling and transcriptional network modeling to link the Vel-negative phenotype to SMIM1, located in a 97-kb haplotype block on c
The first generation of forest free-air CO2 enrichment (FACE) experiments has successfully provided deeper understanding about how forests respond to an increasing CO2 concentration in the atmosphere. Located in aggrading stands in the temperate zone, they have provided a strong foundation for testing critical assumptions in terrestrial biosphere models that are being used to project future intera
