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The majority of the world’s peatlands are located in northern regions where climate change is occurring most rapidly. Therefore, there is an urgent need to understand whether, and under what conditions, peatlands will remain carbon sinks or become carbon sources. The uncertainties in our predictions stem from a variety of sources, including uncertainty about the competing effects of rising air tem
The fate options of hematopoietic stem cells (HSCs) include self-renewal, differentiation, migration, and apoptosis. HSCs self-renewal divisions in stem cells are required for rapid regeneration during tissue damage and stress, but how precisely intracellular calcium signals are regulated to maintain fate options in normal hematopoiesis is unclear. S100A6 knockout (KO) HSCs have reduced total cell
Neurogenesis, the production of new neurons from neural stem cells, dramatically decreases during aging concomitantly with increased inflammation both systemically and in the brain. However, the precise role of inflammation and whether local or systemic factors drive the neurogenic decline during aging is poorly understood. Here, we identify CXCR5/5/CXCL13 signaling as a novel regulator of neuroge
Stem cell transplantation can improve behavioral recovery after stroke in animal models but whether stem cell-derived neurons become functionally integrated into stroke-injured brain circuitry is poorly understood. Here we show that intracortically grafted human induced pluripotent stem (iPS) cell-derived cortical neurons send widespread axonal projections to both hemispheres of rats with ischemic
Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer (NSCLC) risk, biological mechanisms of these variants remain largely unknown. By integrating a large-scale genotype data of 15 581 lung adenocarcinoma (AD) cases, 8350 squamous cell carcinoma (SqCC) cases, and 27 355 controls, as well as multiple transcriptome and e
Noroviruses are the major cause for viral acute gastroenteritis in the world. Despite the existing infection prevention strategies in hospitals, the disease continues to spread and causes extensive and numerous outbreaks. Hence, there is a need to investigate the possibility of airborne transmission of norovirus. In this study, we developed an experimental setup for studies on the infectivity of a
OBJECTIVE: While existing evidence supports beneficial cardiovascular effects of glucagon-like peptide 1 (GLP-1), emerging studies suggest that glucose-dependent insulinotropic peptide (GIP) and/or signaling via the GIP receptor may have untoward cardiovascular effects. Indeed, recent studies show that fasting physiological GIP levels are associated with total mortality and cardiovascular mortalit
The aim with this study was to investigate the senses of the lexemes /assassinated/, /killed/, and /murdered/ in 21st century American and British newspaper discourse, which was done with the method of corpus-driven Cognitive Linguistics. The main research questions dealt with how the combination of grammatical and contextual features of the articles frame patients and agents of the verbs. A focus
Almost 90% of the international trade is managed by ship, which has being dominated the international transportation over hundreds of years. The role of Documents in international trade, has turned the “money and goods” transaction into later “money and documents” transaction and in the process of improving international trade, a lot of by-products have formed at the mean time, one such being docu
The increasingly competitive climate has caused companies to pursue counteractive strategies such as M&As in the hope to attain synergy potential. However, M&As are associated with a high failure rate and synergy realization is often unsuccessful. One area poorly covered in previous literature and often unattended by merging parties is synergies within logistics, despite its significance f
The question of environmental protection has lately become essential due to the increased number of polluters and accidents that have occurred in recent decades. The starting point was the Torrey Canyon disaster which happened in March 1967 and exposed the entire international community to a great danger of environmental harm in general and marine pollution in particular. The accident also pointed
Epigenome-wide studies of pancreatic islets provide valuable insights into type 2 diabetes (T2D) but lack methylomes from individual cell types. Here we show changes to alpha and beta cell-specific methylomes and transcriptomes from people with or without T2D, using whole-genome bisulfite sequencing and RNA sequencing. We discover 22,544 differentially methylated regions annotated to 7,975 genes i
Spark discharge generators (SDGs) are versatile tools for producing nanoparticles (NPs) with tailored properties. This study combines Computational Fluid Dynamics (CFD) and Particle Tracing (PT) simulations in COMSOL Multiphysics® with experimental data to investigate the effect of various chamber configurations, including inlet/outlet positioning and chamber volume on the NP output. Five geometri
Gate-tunable Josephson junctions with molybdenum superconducting contacts are reported. The Josephson field-effect transistors are based on an (In,Ga)As quantum well heterostructure with Mo contacts deposited on a layer of heavily doped (In,Ga)As by HCl cleaning and sputtering. We reproduced the measured data using a quasiballistic model that captures the gate dependence of the critical current an
We demonstrate the first fully vertical single-fin AlGaN FinFETs (Al = 2.5%) on ammonothermal n+-GaN substrates, featuring a gate length of Lg = 200 nm and excellent gate control. This work presents a systematic study of the impact of fin orientation along the a- and m-crystallographic planes on the electrical performance of AlGaN vertical FinFETs. We report that threshold voltage is maximized at
Objective: Meniscal calcifications are associated with meniscal degeneration and osteoarthritis (OA). We investigated micro-computed tomography (μCT) imaging for identification of calcification patterns caused by basic calcium phosphate (BCP) and calcium pyrophosphate (CPP). Design: Posterior horns of human medial and lateral menisci from 19 individuals with medial compartment knee OA and 21 decea
