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Purpose: Host factors, including genetic factors, are underutilized in breast cancer treatment selection. This study aimed to investigate AIB1 genotypes as pharmacogenetic markers for adjuvant breast cancer treatment. The prognostic impact of three functional polymorphisms associated with altered mRNA expression rs6094752 (low expression), rs2230782 (low expression) and rs2076546 (high expression)
Antimicrobial resistance in pathogenic mycobacteria remains a critical challenge due to poor drug penetration through their complex cell wall, which necessitates prolonged multidrug regimens. Mycobacteriophages encode a lytic machinery that can disrupt this barrier. In this research article, we describe a modular mycolysin platform combining phage enzymes Lysin A and Lysin B with outer membrane-pe
Wide-angle neutron scattering analysed using empirical potential structure refinement (EPSR) was used to investigate how aromatic ring structure influences micelle self-assembly in two anionic surfactants: sodium 4-heptylbenzene sulfonate (SHBS) and sodium 5-heptylfuran-2-sulfonate (SHFS). Both surfactants formed globular micelles in aqueous solutions at 0.2 M but differed significantly in micelle
Objectives: To evaluate the impact of the 2018 switch from PCV13 to PCV10 in Sweden’s childhood immunisation programme on the serotype distribution of Streptococcus pneumoniae.MethodsRespiratory tract (RT) S. pneumoniae isolates (n=1615; 2020–2023) were serotyped, tested for antimicrobial susceptibility and compared with invasive pneumococcal disease (IPD) isolates (n=397) and PCV13-era data (2016
Electrostatic energy plays a pivotal role in the minimization of the free energy of self-assembling oppositely charged ions. This is a fundamental principle that guides the formation of aggregates and the separation of phases characterized by a stoichiometric balance between the opposite charges. However, this study unveils the self-assembly of catanionic nanotubes from a mixture of oppositely cha
The term 'Object Shift' means that a weak object pronoun has been raised to a position to the left of a sentence adverbial. In Swedish, there are mainly two positions to which a weak object pronoun can be raised; one of them is called 'Long Object Shift' or 'LOS'. In this paper, I deal with argument structures in constructions with LOS in Old Swedish. The purpose is to prov
Uppsatsen fokuserar på privat skadeståndstalan vid konkurrensrättsliga överträdelser och på det nya direktivet 2014/104/EU, om vissa regler som styr skadeståndstalan enligt nationell rätt avseende överträdelser av medlemsstaternas och Europeiska unionens konkurrensrättsliga bestämmelser. Enligt unionsrätten har alla enskilda aktörer rätt till ersättning för skada som uppkommit till följd av en öveThe main focus of this thesis are private actions for damages due to infringements of the antitrust rules and the new directive 2014/104/EU, on certain rules governing actions for damages under national law for infringements of the competition law provisions of the Member States and of the European Union. According to European union law, all private actors are entitled to compensation for damages
Inom läkemedelssektorn, originalföretagen som investerar stora summor pengar i forskning och utveckling av nya läkemedel vanligtvis söker patent för flera skyddsområden. De försöker utnyttja det monopol ett patent ger för att skydda sina egna originalläkemedel mot generiska läkemedels marknadsinträde och utebliven vinst som det för med sig. Generiska företag för att kunna lansera sina generiska prIn the pharmaceutical sector, originator companies that invest large sum of money in R&D of new medicines usually file patent applications for several areas of protection. They try to take advantage of a monopoly that a patent grants to protect their medicines against generic entry on the market and consequently the loss of profits. Generic companies in order to be able to launch their generic
Land use change is a factor not often considered when modeling river discharge in regard to future flood risk. The restoration of wetlands is an ongoing land use change which affects water storage capacity in the soils of a catchment and could lead to lower flows in rivers. This study analysed the effect of an increased wetland area on river discharge in the Bråån catchment in Skåne, Sweden. D
There are many advantages with the development towards Integrated Circuits (ICs) with smaller, faster, and more transistors. However, tighter margins lead to a need of on-chip instruments to test, tune, and configure. These on-chip instruments, which can be in the range of thousands per IC, must be accessed through the life-time. However, access is challenged by complex system hierarchies. When IC
This meta-analysis and systematic review examined the effects of psychedelic substances on death anxiety, specifically evaluating whether psychedelic experiences are associated with statistically significant reductions in death anxiety. Studies were eligible if they quantitatively assessed death anxiety or death acceptance using validated measures, or qualitatively explored attitudes toward death
