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Diabetic kidney disease (DKD) is a leading cause of end-stage renal disease and renal replacement therapy worldwide. A pathophysiological hallmark of DKD is glomeru- lar basal membrane (GBM) thickening, whereas this feature is absent in minimal change disease (MCD). According to fundamental transport physiological principles, a thicker GBM will impede the diffusion of middle-molecules such as cyst
Resistance to therapy remains a major cause of cancer treatment failures, resulting in many cancer-related deaths. Resistance can occur at any time during the treatment, even at the beginning. The current treatment plan is dependent mainly on cancer subtypes and the presence of genetic mutations. Evidently, the presence of a genetic mutation does not always predict the therapeutic response and can
The annexin A5 gene (Anxa5) was recently found to be expressed in the developing and adult vascular system as well as the skeletal system. In this paper, the expression of an Anxa5-lacZ fusion gene was used to define the onset of expression in the vasculature and to characterize these Anxa5-lacZ-expressing vasculature-associated cells. After blastocyst implantation, Anxa5-lacZ-positive cells were
Aims/hypothesis: Genome-wide association studies (GWAS) have identified more than 65 genetic loci associated with risk of type 2 diabetes. However, the contribution of distorted parental transmission of alleles to risk of type 2 diabetes has been mostly unexplored. Our goal was therefore to search for parent-of-origin effects (POE) among type 2 diabetes loci in families. Methods: Families from the
Aims: Climate change is known to drive both the reshuffling of whole assemblages and range shifts of individual species. Less is known about how local colonizations and extinctions of individual species contribute to changes at the community level. Our aim was to estimate the contribution of individual species to a change in community composition attributed to climate change and to relate these sp
In agricultural landscapes, sown flower strips can benefit pollinators and pollination of nearby plants, but their impact on pollination in the wider landscape is poorly studied. We evaluated effects on reproductive success of field bean (Vicia faba) and woodland strawberry (Fragaria vesca) using data from two study systems, both including study sites (1 km radius) with (flower strip sites) or wit
To promote a more sustainable agricultural production, the European Commission implemented direct payments that require farmers to implement greening measures aimed at reducing negative effects of agriculture on the environment and biodiversity. These greening measures (including fallows and permanent grasslands) have been criticised for their potential inability to conserve biodiversity and promo
Aims/hypothesis: Gene–macronutrient interactions may contribute to the development of type 2 diabetes but research evidence to date is inconclusive. We aimed to increase our understanding of the aetiology of type 2 diabetes by investigating potential interactions between genes and macronutrient intake and their association with the incidence of type 2 diabetes. Methods: We investigated the influen
Academic debates on the role and position of civil society organisations (CSOs) in welfare states largely refer to policies and practices outlined at the national level. They therefore fail to recognise variations within nations. Based on a comparative case study of three Swedish metropolitan cities, this article illustrates the importance of local, contextualised analyses. Through the concept of Academic debates on the role and position of civil society organisations (CSOs) in welfare states largely refer to policies and practices outlined at the national level. They therefore fail to recognise variations within nations. Based on a comparative case study of three Swedish metropolitan cities, this article illustrates the importance of local, contextualised analyses. Through the concept of
Many studies have investigated effects of organic farming on the abundance and diversity of farmland birds, but few have considered how these effects vary between seasons. We analysed the effects of organic farming during an entire year in a previously understudied region, Galicia (North-West Spain), a relatively heterogeneous landscape which is an important wintering and breeding ground for birds
Pseudouridylation (Ψ) is the most abundant and widespread type of RNA epigenetic modification in living organisms; however, the biological role of Ψ remains poorly understood. Here, we show that a Ψ-driven posttranscriptional program steers translation control to impact stem cell commitment during early embryogenesis. Mechanistically, the Ψ “writer” PUS7 modifies and activates a novel network of t
Denna studie undersöker hur den svenska staten uttrycker sig kring nyttjande av mark för urfolk nationellt kontra internationellt med hjälp av teorierna postkolonialism, intern kolonialism samt saltvattenskolonialism. Således består materialet av uttryck från staten i form av regering, ministrar, Sida samt den statligt finansierade fonden the Tenure Facility. Analysen förs sedan genom metoden What
Den här uppsatsen undersöker Europadomstolens praxis gällande utvisningar av personer som har begått brott, som hävdar att deras utvisning strider mot Artikel 8 av Europakonventionen. Uppsatsen undersöker hur domstolen har använt sig av den nationella beslutsprocessens kvalitet som ett argument för att komma fram till sin slutsats i sådana fall. Uppsatsen utgår från premissen att utvisningar som bThis thesis examines the practice of the European Court of Human Rights to decide expulsion cases implicating migrants with criminal record under Article 8 of the European Convention on Human Rights by use of process-based review. It departs from the premise that such expulsions do not violate absolute rights but constitute interferences with a qualified right, which allows for infringements neces
Uppsatsen syftar till att söka förståelse till varför tvister mellan fackförbund om vem som ska teckna kollektivavtal uppstår. Arbetsmarknadernas parter är i allmänhet ense om att det som regel bör finnas ett kollektivavtal på varje avtalsområde. Kollektivavtalets speciella rättsverkningar gör det viktigt för fackförbunden att vara avtalspart i ett kollektivavtal. Kollektivavtalet sätter i stor utThe aim of this essay is to seek understanding about why conflicts appear between trade unions regarding which one of them should sign the collective agreement in the workplace. The labour market parties are in general in an agreement that there should only be one applicable collective agreement in every area of work. The unique effects of the collective agreement make it crucial for the trade uni
The purpose of this study was to examine narratives from people who went from the assigned gender boy or girl, to the opposite binary gender identity, concerning differences in treatment from others, before and after a transition. Data were collected through a survey administered online, a total of fourteen questions about how their emotions were met before and after the transition. Questions were
The role of the museum within society today is significantly different from how it used to be. The last five decades have seen an increase in focus on pedagogy, accessibility and outreaching activities within the museums, and it has had an effect on both how the museum is viewed from the public eye, as well as how the work within the organisations is carried out, by the increasing amount of differ
Access to clean drinking water is a human right and a necessity for life, yet many rely on precarious water sources across the world. The United Nations outlines a great aspiration in Agenda 2030 - that safe and affordable drinking water should be available for all by 2030. In Rio Grande do Sul (RS) in Brazil, more than one million residents rely on small-scale water supply solutions without conve
