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Purpose: To develop a candidate instrument to assess image quality in digital mammography, by identifying clinically relevant features in images that are affected by lower image quality. Methods: Interviews with fifteen expert breast radiologists from five countries were conducted and analysed by using adapted directed content analysis. During these interviews, 45 mammographic cases, containing 44
Background: Tyrosine kinase inhibitors (TKIs) have improved the survival of patients with chronic myeloid leukaemia. Many patients have deep molecular responses, a prerequisite for TKI therapy discontinuation. We aimed to define precise conditions for stopping treatment. Methods: In this prospective, non-randomised trial, we enrolled patients with chronic myeloid leukaemia at 61 European centres i
Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response. Objective: To examine GWG, adverse perinatal outcomes, substrate change
Quantum instruments describe both the classical outcome and the updated state associated with a quantum measurement. We ask whether these processes can be simulated using only a natural subset of resources, namely projective measurements on the system and quantum processing of the postmeasurement states. We show that the simulability of instruments can be connected to an entanglement classificatio
Introduction: Myocarditis is a complex cardiac disorder with multifactorial etiology, characterized by myocardial inflammation, cardiomyocyte damage, and fibrosis. Left untreated, myocarditis may lead to acute and chronic heart failure and life-threatening arrhythmias. Reliable experimental models of myocarditis are required to study the underlying pathological mechanisms of the disease and to dev
The concept of scattering contrast is central to (small-angle) scattering of neutrons, X-rays, and visible light, as it defines the visibility to the radiation of the nano- and mesostructures under scrutiny, in their respective solvent or matrix. In this chapter, we start with the scattering process by elementary scatterers, such as nuclei or atoms, which produce secondary, scattered waves, and th
Objective: Drug-coated balloons (DCB) might improve the results of below the knee (BTK) angioplasty, but sufficient randomized data comparing DCB and conventional angioplasty in treating patients with chronic limb threatening ischemia (CLTI) are lacking. This study aimed to perform a randomized comparison between a paclitaxel-coated angioplasty balloon catheter and a conventional balloon angioplas
Air pollution is increasingly discussed as a risk factor for dementia, but the biological mechanisms are not yet fully understood. Biological markers like telomere length are relevant to study with air pollution, as they are associated with aging and dementia. The study aimed to investigate the relationship between source-specific air pollution exposure and telomere length in a low-level air pollu
Osteoarthritis is a multifactorial disease commonly affecting knee, hip, hand, and spine but other joints also may be affected. Well-known risk factors for symptomatic osteoarthritis include age, overweight or obesity, female gender, and joint injury. Accumulating evidence support that osteoarthritis progression is often driven by biomechanical forces, and the pathological response of tissues to s
Objective: To describe the use of non-steroidal anti-inflammatory drugs (NSAID), opioids, and physiotherapy (PT) among persons with newly diagnosed knee or hip osteoarthritis (OA) with and without NSAID contraindications or precautions. Design: We used population-based register data to identify adults aged ≥35 as of January 1, 2014, residing in Skåne region (Sweden) between 2004 and 2013, without
Simultaneous digital breast tomosynthesis and mechanical imaging (DBTMI), a novel screening approach, combines anatomic DBT with functional analysis of the stress distribution on the compressed breast by mechanical imaging (MI). Preliminary studies suggest potential to reduce false positive findings. DBTMI requires to align DBT and MI images. In this study, we have analyzed robustness to alignment
OBJECTIVE: This systematic scoping review aimed to map the literature on the use of various nudging strategies to influence prescriber behavior toward reducing opioid prescriptions across diverse healthcare settings.METHODS: A systematic database search was conducted using seven electronic databases. Only articles published in English were included. A total of 2234 articles were identified, 35 of
Abstract In this contribution, party autonomy is discussed in relation toEuropean family and succession law. The topic is briefly introduced, followedby a survey covering the main EU-instruments with particular emphasis onthe parties’ possibility to influence choice of court and law by agreements.Thus, autonomy as described in this contribution embraces both prorogationand choice of law. The contr
A recent workshop brought together global leaders in diabetes to assess existing approaches to disease heterogeneity and to identify research gaps, with a goal of achieving precision diabetology for all patients globally.
Objectives: Adverse pregnancy outcomes are more common in women with SLE compared with healthy women, but we lack prognostic biomarkers. Plasma IFN-α protein levels are elevated in a subgroup of pregnant women with SLE, but whether this is associated with pregnancy outcomes is unknown. We investigated the relationship between IFN-α, adverse pregnancy outcomes and the presence of autoantibodies in
A repulsively interacting Bose-Einstein condensate on a ring is well known to show persistent currents. For attractive interactions, however, a bound state may form that renders the rotation classical. Here we show that in a multiply connected confinement, the strong in-plane attraction of an antidipolar condensate can form stacks of ring-shaped density lumps which may coherently overlap to form a
Random access codes are a type of communication task that is widely used in quantum information science. The optimal average success probability that can be achieved through classical strategies is known for any random access code. However, only a few cases are solved exactly for quantum random access codes. In this paper, we provide bounds for the fully general setting of n independent variables,
