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High-efficiency single-photon detection in the microwave domain is a key enabling technology for various quantum applications. However, the extremely low energy of microwave photons presents a fundamental challenge, preventing direct photon-to-charge conversion as achieved in optical systems using semiconductors. Here, we demonstrate continuous microwave photon detection with an efficiency approac
We propose and analyze a microwave spin-photon interface based on a circular double quantum dot, inspired by recent experimental observations of anisotropic g-factors and orbital ring states in InAs nanowires. We develop an effective theoretical model, capturing the interplay of spin-orbit coupling and the magnetic flux, and show how ring states form at crossings of odd and even geometric parity o
Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by age-related somatic mutations in hematopoietic stem and progenitor cells (HSC/Ps) and is correlated with an increased risk of myeloid malignancies, elevated inflammatory pathways in circulating myeloid cells, higher all-cause mortality, chronic kidney disease, and cardiovascular disease. The pathophysiology of inflammatory
Demonstration of a nontrivial result of quasiparticle exchange (or braiding) is usually considered the definitive proof of a topological phase with non-Abelian excitations, such as Majorana bound states (MBSs). However, in finite systems with disorder and smooth potential variations, the MBSs are imperfect in the sense that they are not fully isolated in space and can, to a varying degree, resembl
Protecting qubits from perturbations is a central challenge in quantum computing. Topological superconductors with separated Majorana bound states (MBSs) provide a strong form of protection that only depends on the locality of perturbations. While the link between MBS separation, robust degeneracy, and protected braiding is well understood in noninteracting systems, recent experimental progress in
Aims: Acute myocarditis is an immune-mediated inflammatory disease characterized by myocardial inflammation and oedema. Although cardiac lymphatic vessels are essential for fluid clearance and immune regulation, their role in modulating autoimmune cardiac inflammation remains largely undefined. We aimed to determine whether promoting lymphangiogenesis could mitigate inflammation and preserve cardi
The concept of “vulnerable plaque” (VP) has been evolving since its introduction as an atherosclerotic plaque prone to cause cardiovascular events, such as myocardial infarction and stroke. Once defined as a thin-cap fibroatheroma prone to rupture, it now encompasses more atherosclerotic lesion types, including plaque erosion, fissure, and calcified nodules. Along with deeper understanding of plaq
BACKGROUND: Pramipexole, a dopamine agonist, has demonstrated antidepressant efficacy as an augmentation strategy in unipolar and bipolar depression. However, dopaminergic treatments are associated with impulse control disorders, including gambling disorder, and evidence regarding behavioural risks in psychiatric populations remains limited.METHODS: We conducted a nationwide register-based cohort
Evidence is limited for the association between parental income during childhood and adolescence and the subsequent risk of drug use disorder (DUD) in the second generation and whether the association is modified by region of origin. Identifying the association and effect modification by immigrant background and region of origin would provide an important knowledge base to consider tailored polici
Topological qubits based on non-Abelian Majorana bound states (MBSs) are protected by parity which is challenged by quasiparticle poisoning (QPP). In this work, we show how QPP affects transport through a pair of coupled MBSs weakly connected to two current leads, using an open system approach and full counting statistics. We find that the correct low-energy physics requires one to include next to
Sodium dodecyl sulfate (SDS) forms elongated micelles in urea:choline chloride deep eutectic solvent (DES), unlike its spherical aggregates in water. To understand the driving forces, we employed a multiscale simulation approach combining coarse-grained (CG) (Martini 3) and backmapped atomistic (CHARMM36) models. Simulations confirmed that micelle elongation increases with higher urea:choline chlo
Objective: Philadelphia-negative myeloproliferative neoplasms (MPNs) commonly share hyperactive JAK-STAT signaling affecting hematopoietic stem cells (HSC) and their progeny. The JAK1/2 inhibitor Ruxolitinib has remarkable clinical efficacy, including spleen reduction, improvement of constitutional symptoms, and bone marrow (BM) fibrosis reversal. Whether this is due to inhibition of JAK2-mutated
Conventional agricultural practices can lead to soil erosion and a reduction in soil organic carbon (SOC) content. It has been suggested that less intensive agricultural practices, such as conservation tillage (including no-till and reduced till without soil inversion) may reduce both erosion and loss of SOC. The aim of this study was to determine whether, and why, conservation tillage is used in
The Xga blood group is differentially expressed on erythrocytes from men and women. The underlying gene, PBDX, was identified in 1994, but the molecular background for Xga expression remains undefined. This gene, now designated XG, partly resides in pseudoautosomal region 1 and encodes a protein of unknown function from the X chromosome. By comparing calculated Xga allele frequencies in different
To understand the developmental trajectories in early lymphocyte differentiation, we identified differentially expressed surface markers on lineage-negative lymphoid progenitors (LPs). Single-cell polymerase chain reaction experiments allowed us to link surface marker expression to that of lineage-associated transcription factors (TFs) and identify GFRA2 and BST1 as markers of early B cells. Funct
BACKGROUND: Respiratory tract deposition of airborne particles is a key link to understand their health impact. Experimental data are limited for vulnerable groups such as individuals with respiratory diseases. The aim of this study is to investigate the differences in lung deposition of nanoparticles in the distal lung for healthy subjects and subjects with respiratory disease.METHODS: Lung depos
The use of manufactured nanomaterials is rapidly increasing, while our understanding of the consequences of releasing these materials into the environment is still limited and many questions remain, for example, how do nanoparticles affect living organisms in the wild? How do organisms adapt and protect themselves from exposure to foreign materials? How does the environment affect the performance
Amazonia is an environmentally heterogeneous and biologically megadiverse region, and its biodiversity varies considerably over space. However, existing knowledge on Amazonian biodiversity and its environmental determinants stems almost exclusively from studies of macroscopic above-ground organisms, notably vertebrates and trees. In contrast, diversity patterns of most other organisms remain elusi
