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Objective: Targeted Health Dialogues (THD) is a public health intervention program that aims at preventing cardiovascular disease. THDs were implemented in the Swedish region Scania, in 2020, with the novelty of being conducted in a metropolitan area with a multiethnic population. This study investigated the prevalence of obesity among 40-year-old THD participants in Scania by region of birth, and
Collagen VI (Col-VI) is an extracellular matrix protein primarily known for its bridging role in connective tissues that has been suggested to play a neuroprotective role. In the present study we report increased mRNA and protein expression of Col-VI in the hippocampus and cortex at a late stage of epileptogenesis in a post-status epilepticus (SE) model of epilepsy and in brain tissue from patient
Streptococcus pneumoniae is a bacterium of great global importance, responsible for more than one million deaths per year. This bacterium is commonly acquired in the first years of life and colonizes the upper respiratory tract asymptomatically by forming biofilms that persist for extended times in the nasopharynx. However, under conditions that alter the bacterial environment, such as viral infec
Challenges from infections caused by biofilms and antimicrobial resistance highlight the need for novel antimicrobials that work in conjunction with antibiotics and minimize resistance risk. In this study we investigated the composite effect of HAMLET (human alpha-lactalbumin made lethal to tumor cells), a human milk protein-lipid complex and amoxicillin on microbial ecology using an ex vivo oral
This thesis work has focused on the platinum-tin surface, especially how it behaves when exposed to gases like oxygen and carbon monoxide. Platinum-tin is used as a catalyst for a range of reactions, including the oxidation of carbon monoxide at mild conditions, which is important for gas purification in fuel cells. The platinum-tin alloy has properties useful for the reactions it catalyses, but i
Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respe
BACKGROUND: Although intensive blood pressure (BP) control has not been shown to slow the progression of chronic kidney disease (CKD), intensive BP control has been shown to reduce the risk for adverse cardiovascular outcomes in the CKD population. The aim of this post-hoc study was to study the interplay between a self-monitoring BP system and glomerular function.METHODS: In all, 949 participants
This research presents advancements into the fabrication, operation and characterization of electronicnanomaterials and devices. It focuses on the interfaces of metals, oxides and semiconductors anddeveloping techniques to improve their integration into devices. Covering nanoelectronics fromphotovoltaics to circuit elements, a combined suite of scanning probe and X-ray techniques was usedto provid
This article surveys the reception of the Gnostic text Pistis Sophia in esoteric milieus in nineteenth- and early twentieth-century Europe. The first part of the article contains an overview of the text and scholarship on it. Then follows a study of the reception of Pistis Sophia in a broader array of esoteric circles. It becomes clear that the text was hailed as an example of ancient and great spThis article surveys the reception of the Gnostic text Pistis Sophia in esoteric milieus in nineteenth- and early twentieth-century Europe. The first part of the article contains an overview of the text and scholarship on it. Then follows a study of the reception of Pistis Sophia in a broader array of esoteric circles. It becomes clear that the text was hailed as an example of ancient and great sp
Alzheimer’s Disease (AD) is a devastating neurodegenerative disease associated with massive neuronal cell death during its pathology. The involvement of the amyloid β 42 (Aβ42) peptideand its role in neurotoxicity is now well established. It is known that the production of oligomers during the aggregation of Aβ42 into highly ordered fibrils is responsible for neuronal cell death. However, the effo
The chaperone DNAJB6b delays amyloid formation by suppressing the nucleation of amyloid fibrils and increases the solubility of amyloid-prone proteins. These dual effects on kinetics and equilibrium are related to the unusually high chemical potential of DNAJB6b in solution. As a consequence, the chaperone alone forms highly polydisperse oligomers, whereas in a mixture with an amyloid-forming prot
Background: Essential proteins play an important role in the process of life, which can be identified by experimental methods and computational approaches. Experimental approaches to identify essential proteins are of high accuracy but with the limitation of time and resource-consuming. Objective: Herein, we present a computational model (PEPRF) to identify essential proteins based on machine lear
Mesenchymal cells are important components of specified niches in the lung, and can mediate a wide range of processes including tissue regeneration and repair. Dysregulation of these processes can lead to improper remodeling of tissue as observed in several lung diseases. The mesenchymal cells responsible remain poorly described, partially due to the heterogenic nature of the mesenchymal compartme
α-synuclein is an intrinsically disordered protein implicated in synaptic vesicle trafficking at the synapse. Accumulation of α-synuclein in the form of amyloid deposits coincides with the loss of dopaminergic neurons in Parkinsons disease. These deposits, referred to as Lewy Bodies, have been shown to contain membrane lipids together with the α-synuclein amyloid fibrils and other proteins. It was
Northern forest soils are a major carbon (C) reservoir of global importance. To estimate how the C balance in these soils will change, the roles of tree roots and soil microbes in C balance should first be decoupled. This study determined how the activity of heterotrophs and tree roots together with root-associated microbes in the rhizosphere varies in coniferous forest soils in boreal, hemiboreal
Several publications describing high-resolution structures of amyloid-β (Aβ) and other fibrils have demonstrated that magic-angle spinning (MAS) NMR spectroscopy is an ideal tool for studying amyloids at atomic resolution. Nonetheless, MAS NMR suffers from low sensitivity, requiring relatively large amounts of samples and extensive signal acquisition periods, which in turn limits the questions tha
Objective The prevalence of type 2 diabetes (T2D) among Iraqi immigrants to Sweden is high and partly related to sedentary physical activity and calorie dense food. The aim of the present study was to explore perceptions, experiences and barriers concerning lifestyle modifications (LSM) in Iraqi immigrants to Sweden at risk for T2D. Design A qualitative thematic analysis was conducted on data coll
Non-western immigrants have a higher prevalence of type 2 diabetes and earlier onset than non-immigrant Swedes. In this 10-year follow-up including all people in Sweden diagnosed with type 2 diabetes from 2006 onwards (i.e. prescribed glucose lowering medication for type 2 diabetes), the total and cause-specific mortality of first-generation immigrants with type 2 diabetes is lower than in non-imm
Autoantigen discovery is a critical challenge for the understanding and diagnosis of autoimmune diseases. While autoantibody markers in current clinical use have been identified through studies focused on individual disorders, we postulated that a reverse approach starting with a putative autoantigen to explore multiple disorders might hold promise. We here targeted the epidermal protein transglut
