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The study of fluid transport in porous media is crucial for many applications in science and engineering. From a modeling perspective, understanding how diffusion parameters behave when microstructural variations are taken into account is a significant step toward achieving more detailed and accurate model predictions. It is widely recognized that hydraulic tortuosity is typically approximated as
Findings on the correlation between the use of antihypertensive medication and the risk of breast cancer (BC) have been inconsistent. We performed a two-sample Mendelian randomization (MR) using instrumental variables to proxy changes in gene expressions of antihypertensive medication targets to interrogate this. Genetic instruments for expression of antihypertensive drug target genes were identif
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder, increasing both in terms of prevalence and incidence. To date, only symptomatic treatment is available, highlighting the need to increase knowledge on disease etiology in order to develop new therapeutic strategies. Hemizygosity for the gene Engrailed-1 ( En1), encoding a conserved transcription factor es
China's technological growth in recent years has been explosive. Nowadays, Beijing based much of its socio-economic growth on improved technological performance in many areas. What are the main reasons that have enabled China to become a real IT giant? What are the geo-strategic implications of such growth in technology? To what extent can Chinese technical engineering improvements influence the c
Background: Lymphopenia, autoantibodies and activation of the type I interferon (IFN) system are common features in systemic lupus erythematosus (SLE). We speculate whether lymphocyte subset counts are affected by pregnancy and if they relate to autoantibody profiles and/or IFNα protein in SLE pregnancy. Methods: Repeated blood samples were collected during pregnancy from 80 women with SLE and 51
Amyloid proteins are species whose aggregation has been associated with various neurodegenerative diseases. While intrinsically disordered in their monomeric form, they tend to aggregate into highly ordered β-sheet rich fibrils. Nevertheless, many studies indicate that intermediate species known as amyloid oligomers, which are linked to neurotoxicity, may be the connection between amyloid proteins
Vacuum diffusion-bonded printed circuit heat exchangers are an attractive choice for the high-temperature, high-pressure demands of next-generation energy applications. However, early reports show that the high-temperature materials desired for these applications suffer from poor bond strengths due to precipitation at the bond line, preventing grain boundary migration. In this study, a diffusion b
Sweden’s child welfare services are characterised by intra-organisational specialisation and collaboration with Barnahus as a standard procedure in cases of child abuse. This chapter examines what happens with social workers’ risk assessments when they are both filtered internally at different units and in relation to Barnahus and a criminal law-oriented logic. Various organisational tensions are
Multimorbidity, i.e., two or more non-communicable diseases (NCDs), is an escalating challenge for society. Venous thromboembolism (VTE) is a common cardiovascular disease and it is unknown which multimorbidity clusters associates with VTE. Our aim was to examine the association between different common disease clusters of multimorbidity and VTE. The study is an extended (1997–2015) cross-sectiona
The development of high-brilliance X-ray sources, such as the fourth-generation diffraction-limited storage rings and X-ray free-electron lasers, have opened up new possibilities for X-ray imaging and pushed the temporal resolutions of imaging techniques to unprecedented levels. Capturing fast dynamics in two-dimensional (2D), three-dimensional (3D), and even four-dimensional (4D, 3D + time) beyon
The use of material extrusion (MEX) has increased rapidly due to the affordability of 3D printers. This has led to a growing demand for improved print quality, high fidelity, strength, or fast print times. In this study, a non-planar approach for better surface quality is investigated. The hardware of a 3-axis MEX printer was developed together with testing new software for non-planar slicing. The
Background: The recent guidelines from the European Society of Cardiology recommends using high-sensitivity cardiac troponin (hs-cTn) in either 0/1-h or 0/2-h algorithms to identify or rule out acute myocardial infarction (AMI). Several studies have reported good diagnostic accuracy with both algorithms, but few have compared the algorithms directly. Objective: We aimed to compare the diagnostic a
BACKGROUND: Type 2 diabetes (T2D) is a major risk factor for carpal tunnel syndrome (CTS) and trigger finger (TF), but less is known regarding the risk of developing T2D after being diagnosed with CTS or TF. CTS and TF could be early signs of preclinical T2D, and early detection of T2D is crucial to prevent complications and morbidity. Therefore, we investigate the association between CTS/TF and T
In microbiology, cell analysis is an important tool for understanding influences on biotechnological production. Using current bulk methods, the secretome cannot be assigned to the corresponding cell. This contribution reports a novel method for cell separation inside microscale droplets. Cells are focused in droplets using bulk acoustic waves before the droplet is split at a bifurcation. For a wi
Within the Langevin framework, we investigate the dynamics of the fusion process for production of transfermium elements in reactions of 48Ca, 50Ti, 54Cr, and 58Fe with 208Pb. After the reacting nuclei have made contact, the early dynamical stage is dominated by the dissipation of the initial radial kinetic energy, while the subsequent shape evolution is diffusive. The probability for surmounting
