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AIM: To evaluate correlations between physical activity, VO2PEAK and body fat versus autonomic function in children.METHODS: Children (n = 98) between 10 and 12 years underwent a maximal exercise test (VO2PEAK) and dual-energy X-ray absorptiometry measured body fat. General physical activity, moderate to vigorous physical activity and vigorous physical activity were assessed by accelerometers. Dee
Hematopoietic cells emerge from hemogenic endothelium in the developing embryo. Mechanisms behind human hematopoietic stem and progenitor cell development remain unclear. Using a human pluripotent stem cell differentiation model, we report that cyclic AMP (cAMP) induction dramatically increases HSC-like cell frequencies. We show that hematopoietic cell generation requires cAMP signaling through th
Metastable nonradiative centers (supertraps) are significant energy loss channels in perovskite optoelectronic devices. In their active state, supertraps induce substantial energy loss through nonradiative recombination of free charge carriers. Transitions between active (energy loss) and passive (no energy loss) states result in photoluminescence (PL) blinking on timescales from milliseconds to s
Background: Patients with hemophilia are reported to have a high prevalence of established and potential risk factors for kidney dysfunction and damage. However, comprehensive studies specifically evaluating kidney function in hemophilia, particularly hemophilia B (HB), are limited, with most research focusing on hemophilia A. Objectives: This study aimed to assess markers of glomerular filtration
Background General adiposity, assessed by body mass index (BMI), is a well-established cancer risk factor. This study compared waist circumference (WC), a measure of abdominal adiposity, with BMI as a risk factor for obesity-related cancers, and assessed whether WC provides additional information beyond BMI. Methods We analyzed data from 339 190 individuals in a pooled Swedish cohort with baseline
Celiac disease etiopathogenesis requires genetic predisposition and exposure to gluten, yet these factors alone are not sufficient. Larger longitudinal studies are needed to determine the role of time-varying infections and gut microorganisms. The aim was to design a celiac disease case-cohort longitudinal study using The Environmental Determinants of Diabetes in the Young (TEDDY) study. By age 3-
Predicting live birth after the first IVF/ICSI treatment is challenging, as many factors may interact to affect IVF/ICSI outcomes. Adenomyosis is one factor that impacts live birth rates. Machine learning algorithms have been shown valuable for detecting complex dependencies and predicting outcomes in different clinical settings. We aimed to develop a prediction model for live birth after IVF/ICSI
Timely diagnosis of type 1 diabetes (T1D), especially in high-risk populations, is crucial for preventing serious health complications. T1D is a chronic progressive autoimmune disease that has presymptomatic stages that can be identified through the detection of islet autoantibodies. Given that T1D is associated with other autoimmune diseases, having either those diseases or a family history of th
Acquisition of complement regulators is a virulence strategy used by nontypeable Haemophilus influenzae (NTHi) to evade complement-mediated killing by the host. The major outer membrane protein of NTHi, P5, binds C4b-binding protein and factor H to promote bacterial serum resistance. We show that P5 also binds vitronectin, which inhibits the formation of the membrane attack complex at the terminal
Objectives To examine the associations between socioeconomic position (SEP) and the incidence of serious hand infections—pyogenic flexor tenosynovitis (PFT) and septic arthritis (SA)—as well as risks of opioid overuse following diagnosis using nation-level data. Design In a registry-based nationwide retrospective cohort study, (1) associations between SEP and incidence of PFT/SA; (2) SEP and infec
LRRK2-PD represents the most common form of autosomal dominant Parkinson’s disease. We identified the LRRK2 p.L1795F variant in three families and six additional unrelated cases using genetic data from over 50,000 individuals. Carriers with available genotyping data shared a common haplotype. The clinical presentation resembles other LRRK2-PD forms. Combined with published functional evidence show
The Applied Nuclear Physics Group at Lund University has constructed a CANS (Compact Accelerator-driven Neutron Source). The CANS is based around a 3 MV, single-ended, Pelletron accelerator, which is used to impinge a 2.8 MeV deuterium beam into a beryllium target. The anticipated neutron production will be on the order of 1010 n/s in 4π sr, with future upgrades expected to increase neutron produc
Importance: Etiologic heterogeneity in breast carcinogenesis needs to be well characterized for targeted prevention. Associations between menopausal hormonal therapy (MHT) and oral contraceptive (OC) use and breast cancer intrinsic-like subtypes are not well understood. Objective: To examine whether exogenous hormone use is differentially associated with breast cancer subtypes and to evaluate hete
AbstractBackgroundThe role of nutrient intake in celiac disease pathogenesis is poorly understood.ObjectiveTo examine whether longitudinal childhood intake of selected vitamins and minerals is associated with celiac disease autoimmunity (CDA, primary outcome) and celiac disease (secondary outcome) in genetically at-risk children.MethodsA total of 6,520 HLA-conferred at-risk children in the observa
