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PURPOSE Effective treatments are needed for melanoma that progresses on inhibitors of programmed cell death protein-1 (PD-1) or its ligand (PD-L1). We conducted the phase II LEAP-004 study to evaluate the combination of the multikinase inhibitor lenvatinib and the PD-1 inhibitor pembrolizumab in this population (ClinicalTrials.gov identifier: NCT03776136).METHODSEligible patients with unresectable

This thesis is based on the results concerning the epitaxial growth and characterization of silicon (Si) and germanium (Ge) nanostructures. The growth technique was the Ultra High Vacuum Chemical Vapor Deposition (UHV-CVD) that works in relatively low temperatures and low growth pressures. The UHV-CVD chamber was also used for the reduction experiments. The work presented here involves three diff

Disposal behaviour represent the last phase in the consumption cycle. From an environmental point of view it is extremely important to know the factors behind individual behaviour in waste handling. There are several aspects of interest, for example willingness of waste separation and re-use of products. The aim of this article is to analyse the importance of environmental concern, disposal behavi

IMPORTANCE: The outcomes of newborn infants of women testing positive for SARS-CoV-2 in pregnancy is unclear.OBJECTIVE: To evaluate neonatal outcomes in relation to maternal SARS-CoV-2 test positivity in pregnancy.DESIGN, SETTING, AND PARTICIPANTS: Nationwide, prospective cohort study based on linkage of the Swedish Pregnancy Register, the Neonatal Quality Register, and the Register for Communicab

Importance: Clonal hematopoiesis of indeterminate potential (CHIP) may contribute to the risk of atrial fibrillation (AF) through its association with inflammation and cardiac remodeling. Objective: To determine whether CHIP was associated with AF, inflammatory and cardiac biomarkers, and cardiac structural changes. Design, Setting, and Participants: This was a population-based, prospective cohort

Microsoft Word - Biologisk mångfald.docx 2015/16       Botaniska trädgårdar och bevarandet av den biologiska mångfalden Av Fredric Ahrling, NA3a Handledare: Katarina Schiemann POLHEMSKOLAN Abstract   Botanical gardens and sustained biodiversity Due to increased awareness of human impact on nature, awareness of the importance of education regarding the matter has increased as well. By educating chi

https://www.botan.lu.se/sites/botan.lu.se/files/biologisk_mangfald.pdf - 2026-07-09

Running head: DIVERSITY AND DANGER 1 Diversity and Danger: Risk Communication in the Heartland Desiree Newhart Hill Anna Kochigina Md. Nazmul Kabir Rony University of Oklahoma DIVERSITY AND DANGER 2 Abstract College students and university communicators intersect in important ways during times of intense crisis. Diverse population groups, a need for risk communication, and technology dependencies

https://www.isk.lu.se/sites/isk.lu.se/files/hill_kochigana_rony_0.pdf - 2026-07-09

Untitled ANNUAL REPORT  INTER ARTS CENTER | FACULTY OF FINE AND PERFORMING ARTS Contents 1 | Welcome ......................................................................................................................... 3 2 | About .............................................................................................................................. 4 3 | Brief facts ................

https://www.iac.lu.se/sites/iac.lu.se/files/2025-04/IAC_report_2024_WEBPAGE.pdf - 2026-07-09

Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort Identification of non-HLA genes associated with development of islet autoimmunity and type 1 diabetes in the prospective TEDDY cohort Ashok Sharma1, Xiang Liu2, David Hadley3, William Hagopian4, Wei-Min Chen5, Suna Onengut-Gumuscu5, Carina Törn6, Andrea K. Steck7, B

https://www.teddy.lu.se/sites/teddy.lu.se/files/identification_of_non-hla_genes_associated_with_development_of_islet.pdf - 2026-07-09

https://www.ub.lu.se/sites/ub.lu.se/files/aldrestatistik-2018.pdf - 2026-07-09

Background: Cataracts are the leading cause of reversible blindness globally, disproportionately affecting populations in low- and middle-income countries. In Ethiopia, cataracts remain a significant public health concern. Despite the effectiveness of cataract surgery in restoring vision, information on recovery time and its predictors remain limited. The aim of this study was to assess time to re

OBJECTIVE AND DESIGN: The objective was to determine the association between serum IgE levels and the infiltration order of T lymphocytes and macrophages in pancreatic islets in relation to the loss of insulin and glucagon cells in presymptomatic congenic BB Gimap5-DP (Diabetes Prone) rats.MATERIAL: Congenic prediabetes BB Gimap5-DP and control Gimap5-DR (Diabetes Resistant) rats were followed eve

There is an urgent need for accurate and validated methods to measure plasma phosphorylated tau (p-Tau) biomarkers in Alzheimer’s disease (AD). In this study, we compared the performance of new commercially available plasma p-Tau217 assay developed by ALZpath to other established p-Tau assays in an autopsy-confirmed sample. We included 72 participants from the Arizona Study of Aging and Neurodegen

Introduction Emerging research indicates that integrated treatment of co-occurring post-traumatic stress disorder (PTSD) and substance use disorder can be effective among adolescents and young people. However, various barriers exist to young people accessing evidence-based treatments. Telehealth offers an opportunity to address these barriers and provide a scalable and accessible alternative to in

Cavum septum pellucidum (CSP) is commonly observed upon neuroimaging examination in individuals exposed to repetitive head impacts (RHI) and post-mortem in cases with chronic traumatic encephalopathy. Consequently, CSP has been proposed as a potential biomarker for RHI-related neurodegeneration, yet prevalence estimates of CSP across other neurodegenerative diseases and its clinical implications a

Syftet med studien är att analysera och förklara hur händelser knutna till avregleringarna påverkat SJ AB i dess strategiutveckling mellan åren 2001-2014. Vidare har vi med studien avsett att förklara hur bolaget arbetat för att implementera strategierna i verksamheten utifrån ett antal ekonomistyrningsverktyg. Resultatet av studien visar att SJ AB i dess strategiutveckling i flera fall avsett at

Name 1 MDC Cardiovascular endpoints 2026-05-13 Contents: Cardiovascular events (coronary events, stroke, coronary artery bypass graft surgery (CABG), percu- taneous coronary artery intervention (PCI), heart failure, atrial fibrillation/flutter and aortic stenosis events), including diagnosis code and date of diagnosis. Separate variables were created for Major Adverse Coronary Events (MACE) based

https://www.malmo-kohorter.lu.se/sites/malmo-kohorter.lu.se/files/2026-05/MDC%20Cardiovascular%20endpoints.pdf - 2026-07-09

Evidence from neuropathological cohorts indicates that a CSF α-synuclein (α-syn) seed amplification assay (SAA) might provide quantitative kinetic parameters correlating with α-syn pathology burden in patients with Lewy body disease (LBD). Studies are needed to assess their longitudinal trend during the presymptomatic and clinical disease phases and their correlation with measures of disease progr