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Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transient state characterized by whole-genome doubling. At the onset of the polyploidization program, we ide
Grassroots innovations are seen as important contributors to sustainability transitions, however, given their dependence on place-specific conditions they face diffusion challenges. Responding to previously outlined gaps regarding conceptualisation and exploration of the spatiality of grassroots innovations, this paper introduces a conceptualisation of nomadic grassroots innovations. These are gra
BACKGROUND: Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) are asymptomatic precursor conditions to multiple myeloma and related disorders. Smoldering multiple myeloma is distinguished from MGUS by 10% or greater bone marrow plasma cells (BMPC) on sampling, has a higher risk for progression, and requires specialist management.OBJECTIVE: To develop a
Aim: The type of surgical procedure used in rectal cancer treatment may affect cancer recurrence. The aim of this study was to determine whether the type of procedure influences oncological outcomes in rectal cancer surgery. Method: We gathered data from the Swedish Colorectal Cancer Registry regarding patients with TNM Stage I–III rectal cancer who underwent R0/R1 surgery from 2013 to 2017. The o
Objective. Ankylosing Spondylitis Disease Activity Score based on C-reactive protein (ASDAS-CRP) is recommended over ASDAS based on erythrocyte sedimentation rate (ASDAS-ESR) to assess disease activity in axial spondyloarthritis (axSpA). Although ASDAS-CRP and ASDAS-ESR are not interchangeable, the same disease activity cut-offs are used for both. We aimed to estimate optimal ASDAS-ESR values corr
The presented guidelines are an update of the position paper, endorsed by the International Osteoporosis Foundation (IOF), on nomenclature of bone markers published over 2 decades ago. Novel insight into bone biology and pathophysiology of bone disorders has highlighted the increasing relevance of new and known mediators implicated in various aspects of bone metabolism. This updated guideline prop
Introduction. This article presents the first results from the LibPrepare research project, which explores how the democratic mission of public libraries is understood, imagined and potentially compromised in times of crisis and war rhetoric. The aim is to gain knowledge of the mechanisms, motives and potential implications of enrolling libraries in Swedish national security policy.Method. A themaIntroduction. This article presents the first results from the LibPrepare research project, which explores how the democratic mission of public libraries is understood, imagined and potentially compromised in times of crisis and war rhetoric. The aim is to gain knowledge of the mechanisms, motives and potential implications of enrolling libraries in Swedish national security policy.Method. A thema
This paper presents an initial technology assessment of the suitability of using aluminium as an energy carrier in shipping. The overall conclusion is that aluminium may become a suitable future energy carrier. Several advantages of using aluminium exist, including high theoretical energy densities, high resource availability, opportunity for circularity, and future potential for low lifecycle env
Introduction Modern systemic treatment has reduced incidence of regional recurrences and improved survival in breast cancer (BC). It is thus questionable whether regional radiotherapy (RT) is still beneficial in patients with sentinel lymph node (SLN) macrometastasis. Postoperative regional RT is associated with an increased risk of arm morbidity, pneumonitis, cardiac disease and secondary cancer.
A search is presented for a heavy resonance Formula Presented decaying into a Standard Model Higgs boson Formula Presented and a new particle Formula Presented in a fully hadronic final state. The full Large Hadron Collider run 2 dataset of proton-proton collisions at Formula Presented collected by the ATLAS detector from 2015 to 2018 is used and corresponds to an integrated luminosity of Formula
We present measurements of cross sections for production of a leptonically decaying Z boson in association with a large-radius jet in 13 TeV proton-proton collisions at the LHC, using 36 fb - 1 of data from the ATLAS detector. Integrated and differential cross sections are measured at particle level in both a flavor inclusive and a doubly b -tagged fiducial phase space. The large-radius jet mass a
Two conspicuous wet shifts in the peat stratigraphy of Store Mosse in southern Sweden, associated with bog-wide changes in vegetation and degree of peat decomposition, were analysed at high resolution. The bog-surface wetness (BSW) proxy data (organic matter bulk density, C/N ratio, plant macrofossils and testate amoebae) highlight the importance of interactions between vegetation composition, mic
Newly diagnosed breast cancer (BC) patients with clinical T1–T2 N0 disease undergo sentinel-lymph-node (SLN) biopsy, although most of them have a benign SLN. The pilot noninvasive lymph node staging (NILS) artificial neural network (ANN) model to predict nodal status was published in 2019, showing the potential to identify patients with a low risk of SLN metastasis. The aim of this study is to ass
Background: The 2030 agenda for sustainable development calls upon all nations to make critical investments in their health systems to deliver universal access to Sexual and Reproductive Health and Rights (SRHR). Capacity development is listed among the strategies for achieving sustainable development goals. Although capacity development has been a major component of international development for
Interviews where photographs taken by the respondent are used in order to stimulate the conversation and to gain rich empirical material are increasingly employed by researchers. The ubiquitous use of mobile cameras and digital platforms such as Instagram has made it easier for the researcher as well as for the interviewees to take and share photographs. The limitations of participatory visual met
As global temperatures rise, adverse health effects due to heat exposure are an increasingly pressing issue, particularly threatening to the health of elderly people. Mitigating these threats requires a dynamic climate adaptation system embedding a variety of measures. Ideally, such a system incorporates the coping strategies and experiences of the vulnerable themselves in a well-developed strateg
Previous research shows that gambling addiction receives less attention in Social services compared with substance abuse. The aim of the study was to compare the child-welfare officer’s view on problem for the child and also on support and assistance for children who grow up in families where parents are compulsive gamblers than in families where parents have a substance abuse (in this paper it wi
