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Blood coagulation factor IX is composed of discrete domains with an NH2-terminal vitamin K-dependent gamma-carboxyglutamic acid (Gla)-containing region, followed by two domains that are homologous with the epidermal growth factor (EGF) precursor and a COOH-terminal serine protease part. Calcium ions bind to the Gla-containing region and to the NH2-terminal EGF-like domain. To be able to determine
Retrograde and transganglionic labeling techniques are commonly used to visualize subsets of neurons and sensory afferent projections in the nervous system. These methods commonly require anesthesia and surgical methods. However, some tracers can also be administered systemically in awake animals, thus reducing risks associated with anesthesia and surgery and allowing for labeling of neuronal popu
Multiple sclerosis (MS) is associated with inflammatory lesions in the brain and spinal cord. The detection of such inflammatory lesions using magnetic resonance imaging (MRI) is important in the consideration of the diagnosis and differential diagnoses of MS, as well as in the monitoring of disease activity and predicting treatment efficacy. Although there is strong evidence supporting the use of
U–Pb baddeleyite ages demonstrate the presence of three dyke generations within the NW-trending Pará de Minas swarm (São Francisco craton, South America), dated at ca. 1795 Ma (1798 ± 4, 1791 ± 7 and 1793 ± 18 Ma), ca. 1710 Ma (1702 ± 13 and 1717 ± 11 Ma) and 766 ± 36 Ma. These ages have implications for the São Francisco-Congo (SF-Congo) craton within the Rodinia and Columbia supercontinent confi
The volcanic Hartley Formation (part of the Olifantshoek Supergroup, which is dominated by red bed successions) in South Africa recorded depositional and tectonic conditions along the western Kaapvaal Craton during the late Palaeoproterozoic. It formed in association with red bed deposition elsewhere in the cratonic hinterland and along the craton’s northern margin. However, the exact correlation
Objectives: To update the EULAR recommendations for management of knee osteoarthritis (OA) by an evidence based medicine and expert opinion approach. Methods: The literature search and guidelines were restricted to treatments for knee OA pertaining to clinical and/or radiological OA of any compartment of the knee. Papers for combined treatment of knee and other types of OA were excluded. Medline a
Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet neuropeptide with potent insulinotropic action. The current study investigates PACAP expression in normal human and rat pancreatic islets, and whether it is altered in diabetic state. To that end, PACAP immunoreactivity was studied by immunofluorescence methods enhanced by the catalyzed reporter deposition (CARD) technique. Ins
Background and Aims: In a retrospective study using stereotactic body radiotherapy (SBRT) in medically inoperable patients with stage I NSCLC we previously reported a local control rate of 88% utilizing a median dose of 15 Gy x 3. This report records the toxicity encountered in a prospective phase II trial, and its relation to coexisting chronic obstructive pulmonary disease (COPD) and cardiovascu
The primary aim of this study has been to explore nonprofit actors’ experiences and understanding of educating children and youth about pornography and sexual violence. Furthermore, the study has explored how nonprofit actors respond to and approach children and youths’ pornography consumption and their exposure to sexual violence. Lastly, the study researched the challenges and possibilities the
This study aimed to examine how school counselors work with children who experience domestic violence, as well as which challenges they face in their work with this group. The study is based on six qualitative interviews with school counselors who all have experience working with children exposed to domestic violence. The interviews were analyzed using two sociological theories: Goffman's dram
Thesis purpose: This thesis aims to discover young Swedish consumers' boycott and buycott behavior of food and drink brands by understanding their decisions and participation in these practices. Methodology: This study is built upon a qualitative research design and adopts an abductive approach. A social constructionist viewpoint guides the research to help to get a deeper understanding of yo
As global temperatures rise, adverse health effects due to heat exposure are an increasingly pressing issue, particularly threatening to the health of elderly people. Mitigating these threats requires a dynamic climate adaptation system embedding a variety of measures. Ideally, such a system incorporates the coping strategies and experiences of the vulnerable themselves in a well-developed strateg
Previous research shows that gambling addiction receives less attention in Social services compared with substance abuse. The aim of the study was to compare the child-welfare officer’s view on problem for the child and also on support and assistance for children who grow up in families where parents are compulsive gamblers than in families where parents have a substance abuse (in this paper it wi
The thesis project explores how emerging technologies and Al Voice Assistants can enhance user understanding of electric vehicles by offering more intuitive, adaptive, and immersive experiences. Users often face challenges understanding how to interact with their vehicle’s autonomous features effectively. This project focuses on bridging that gap by integrating interaction design with Al and eXten
The aim of this study is to explore the system of maintenance treatment for opiate addiction from a patient’s perspective. Six semi structured interviews were performed with persons who are or have been engaged in maintenance treatment. The majority of them had experienced discharge from the program. Our results show that discharge may result in harsh consequences; relapse in heroin use or other i
Authors: Aleksandra Nikolic & Rosil Al-Janabi Title: From romance to abuse of power. A qualitative study of voluntary work with women who are exposed to domestic violence, from a social constructionist perspective with focus on gender. Supervisor: Anders Östnäs The aim of this study was to try and create an understanding on how voluntary organization work with and reaches out to women who ar
