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IntroductionAlthough Chronic Obstructive Pulmonary Disease (COPD) is generally considered a progressive condition with limited reversibility, recent data suggests potential for lung function improvement with exercise. Mechanistic insights into exercise-induced benefits remain limited, but in vitro models offer promise for understanding cellular and molecular changes. This study aims to elucidate t
Background and aimHypoxic-ischaemic encephalopathy (HIE) is a leading cause of morbidity and mortality in unconscious patients resuscitated after out-of-hospital cardiac arrest. Many patients die after withdrawal of life-sustaining treatments (WLST), often due to a presumed poor prognosis. To minimise the risk of premature WLST, guidelines recommend using a multimodal prognostication. Head compute
An induced pluripotent stem cell (iPSC) line was generated from a 36-year-old patient with sporadic Parkinson's disease (PD). Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated cell line (CSC-43) exhibits expression of common pluripotency markers, in vitro differentiation into three germ layers and nor
Levodopa is a precursor to dopamine that has been shown to improve functional recovery following stroke partly achieved through mechanisms of brain plasticity. This study investigates if dopamine might affect plasticity by having a direct effect on synaptic plasticity through alterations in neurotransmitter release and re-uptake. Synaptogyrin is a synaptic vesicle protein that has been suggested t
A new environmental transmission electron microscope has been installed in Lund in order to investigate the growth of III-V semiconductor nanowires by metal-organic chemical vapour deposition. We report here on the concepts behind the design of the facility and on details of the operation, and we refer to early results to highlight the new information that can be accessed from in situ studies. The
The ultrastructural changes in the pyramidal neurons of the CA1 region of the hippocampus were studied 6 h, 24 h, 48 h, and 72 h following a transient 10 min period of cerebral ischemia induced by common carotid occlusion combined with hypotension. The pyramidal neurons showed delayed neuronal death (DND), i.e. at 24 h and 48 h postischemia few structural alterations were noted in the light micros
To study the influence of acidosis on free radical formation and lipid peroxidation in brain tissues, homogenates fortified with ferrous ions and, in some experiments, with ascorbic acid were equilibrated with 5–15% O2 at pH values of 7.0, 6.5, 6.0, and 5.0, with subsequent measurements of thiobarbituric acid-reactive (TBAR) material, as well as of water- and lipid-soluble antioxidants (glutathion
Cerebral ischemia associated with subarachnoid haemorrhage (SAH) may have severe consequences for neuronal function leading to reversible or permanent neurological deficits. The excitatory amino acid neurotransmitters, such as glutamate, have been shown to be of particular importance for ischemic neuronal damage. In seven patients who underwent early surgery for a ruptured intracranial aneurysm, m
Et af de mest interessante spørgsmål en fysiker kan forsøge at svare på er hvad består tingene af?. Et hus kan skilles ad i mursten, og murstenen kan også skilles ad i sine bestanddele.Sådan kan man fortsætte indtil man bare har atomer tilbage. Atomerne kan skilles ad ielektroner og en atomkerne der består af neutroner og protoner. Elektronen er, så vidt vived, fundamental, og kan ikke skilles ad.This thesis concerns models of high energy collisions of sub-atomic particles, and the models’ implementation in numerical simulations; so–called Monte Carlo event generators. The models put forth in the thesis improves the description of soft collisions of protons, and takes the first steps towards a new, microscopic description of collectivity in proton collisions and collisions of heavy nuclei
New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre-existing developmentally generated OB interneurons represent a unique population of cells in the adult brain, without miR-125 activity. Stable
Bacteria of the genera Bacillus and Clostridium can form endospores as a strategy to survive unfavourable environmental conditions. Endospore formation involves synthesis of cortex, a thick layer of modified peptidoglycan that surrounds the spore. This layer is required for heat resistance of the spore and mutant spores lacking the cortex layer can be identified by a simple heat shock assay. B. su
The prevalence of obesity, as well as use of bariatric surgery, has increased worldwide. The aim of the present study was to investigate the potential differences in the use of bariatric surgery among Swedes and immigrants in Sweden and whether the hypothesized differences remain after adjustment for socioeconomic factors.
Föräldraskap, intervention och prevention vid barnövervikt/fetma hos förskolebarn med utgångspunkt ifrån ett barn- och familjepsykologiskt perspektiv är ämnet för denna uppsats. Psykologiska faktorer av betydelse för barns ätande, matens betydelse i familjen, föräldrastress kopplad till barns ätande, liksom tidpunkt och inriktning ifråga om intervention och prevention är ämnen som belyses och diskParenting, intervention and prevention of pediatric overweight/obesity in preschool children from a psychological, child-and family oriented perspective is the subject in this paper. Psychological factors of importance for children's eating, the importance of food in the family, parental stress related to children's eating, timing and focus in intervention and prevention are subjects, high
