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Accurate assessments of symptoms and illnesses are essential for health research and clinical practice but face many challenges. The absence of a single error-free measure is currently addressed by assessment methods involving experts reviewing several sources of information to achieve a best-estimate assessment. This assessment method is called the Expert Panel method in medicine, and the Best-Es
Enligt Lagen om skydd mot olyckor (LSO) skall kommunerna beskriva sin riskbild som en del av deras arbete med att utveckla handlingsprogram för olycksförebyggande verksamhet och räddningstjänst. Denna rapport är resultatet av ett uppdrag som utförts av Avdelningen för riskhantering och samhällssäkerhet på uppdrag av Myndigheten för samhällsskydd och beredskap med syftet att föreslå hur man kan utv
The relationship between degree of coronary artery stenosis and its effect on myocardial perfusion is complex and constitutes a clinical challenge. The aim of this study was to assess diagnostic accuracy of visual assessment of invasive coronary angiography (ICA) for detecting reduced myocardial perfusion determined by quantitative first-pass perfusion (qFPP) cardiac magnetic resonance (CMR) in pa
Bakgrund/Syfte: Aktivitetsträning är en ständigt pågående process som innefattar social interaktion och lärande. Synen på människan som en aktiv varelse är central i arbetsterapi och insatserna rör ofta vardagens olika aktivitetsområden så som personlig vård, boende, fritid och arbete. Görandet av aktiviteterna kan beskrivas som en interaktiv social process där personen har ett ständigt utbyte med
In recent years, researchers have extensively investigated hepatocellular carcinoma (HCC), a prevalent cancer type worldwide. Its resistance to conventional treatments highlights the promise of theragnostic nanoparticles, offering multiple tools within a single platform for fighting HCC cells. In this research, using polyaniline (PANI)-coated cobalt ferrite nanoparticles (CFO), an innovative nanoc
We report on an exact theory for ensembles of globally coupled, heterogeneous complex Riccati equations. A drastic dimensionality reduction to a few ordinary differential equations is achieved for Lorentzian heterogeneity. By applying this technique, we obtain low-dimensional firing-rate equations for populations of spiking neurons with a clustered substructure.
Background: Congenital heart disease (CHD) is the most common organ anomaly in humans affecting approximately 1:125 newborns worldwide. Early diagnosis enables postnatal stabilisation and may improve outcomes, especially in critical CHD, in which the circulation is dependent on patency of the arterial duct. Detection of CHD in newborns remains incomplete and current screening programs do not aim t
School-related functional impairment is common in children and adolescents with obsessive-compulsive disorder (OCD). However, little is known about the characteristics of youth with OCD who struggle in school, whether these struggles interfere with treatment outcomes, and whether treatment improves school-related function. Among 385 youth with OCD at a specialist clinic (mean age [sd] = 13.7 [2.5]
Recent studies have demonstrated that the transcription factor hepatocyte nuclear factor 4α (HNF4A) drives epithelial differentiation in the renal proximal tubules (PTs) and is critical for maintaining a mature PT phenotype. Furthermore, HNF4A down-regulation has been observed following kidney injury in mouse models. The aim of the present work was to investigate the role of HNF4A during acute and
One of the key purposes of bone tissue engineering is the development of new biomaterials that can stimulate the body's own regenerative mechanism for patient's anatomical and functional recovery. Bioactive glasses, due to their versatile properties, are excellent candidates to fabricate porous 3-D architectures for bone replacement. In this work, morphological and structural investigations are ca
This thesis discusses the use of standards in land-use planning risk management regulations. Based on exploring the domains of standards and standardisation, risk science, and risk management regulations, the research contributes significant empirical evidence capturing the perspectives of risk managementpractitioners in terms of the strengths, the weaknesses and the effects of using standards in
Context. HR 10 has only recently been identified as a binary system. Previously thought to be an A-type shell star, it appears that both components are fast-rotating A-type stars, each presenting a circumstellar envelope. Although showing complex photometric variability, spectroscopic observations of the metallic absorption lines reveal variation explained by the binarity, but not indicative of de
Wood's flammability, low dimensional stability, and poor fungal resistance limit its application. In this study, Scots pine sapwood (Pinus sylvestris L.) was treated with a low-molecular-weight phenol–formaldehyde (PF) resin and a monoguanidine phosphate flame retardant (FR) to achieve multifunctional enhancement. Differential scanning calorimetry confirmed no interference of FR with PF curing, wh
One of the main challenges in regenerative medicine is the spatiotemporal control of angiogenesis, which is key for the successful repair of many tissues, and determines the proper integration of the implant through the generation of a functional vascular network. To this end, we have designed a three-dimensional (3D) model consisting of a coaxial binary elastin-like recombinamer (ELR) tubular con
In the effort to obtain a precise measurement of leptonic CP-violation with the ESSνSB experiment, accurate and fast reconstruction of detector events plays a pivotal role. In this work, we examine the possibility of replacing the currently proposed likelihood-based reconstruction method with an approach based on Graph Neural Networks (GNNs). As the likelihood-based reconstruction method is reason
Although many efforts have been made to eliminate barriers in public transport worldwide, research shows that public transport is still often perceived as challenging, inconvenient, and inaccessible for many people with disabilities. A growing body of research points to several issues, relating to the spatial and temporal distribution of public transport, affordability, safety, and social barriers
PURPOSE: Techniques for endovascular thrombectomy in acute ischemic stroke due to medium or distal vessel occlusions (MDVO) need to be improved, and first-line aspiration is emerging as a promising technique. The objective was to describe first-pass and final reperfusion rates with a triaxial direct aspiration first pass technique (ADAPT) and a novel, quadriaxial technique (QUATTRO-ADAPT) using RE
The transition to sustainable energy is crucial for modern society, and Reverse Electrodialysis (RED) offers a promising method for harvesting energy from salinity gradients. However, large-scale deployment of RED is constrained by efficiency limitations and the high cost of ion exchange membranes. This study focuses on the development of novel asymmetric cation exchange membranes (CEMs) based on
Provision of assistive technologies (AT) is strongly connected to applying a person-centred approach, with focus on exploring the person’s individual abilities, needs and desires, to enable provision of matching AT. In the process of provision, it is also important to assess and facilitate the person’s understanding of how to use the AT, to enhance optimal usage and enable AT integration in everyd
