Search results

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

The free energy of interaction between two nanometric clay platelets immersed in an electrolyte solution has been calculated using Monte Carlo simulations as well as direct integration of the configurational integral. Each platelet has been modeled as a collection of charged spheres carrying a unit charge-the face of a platelet contains negative charges, and the edge, positive charges. The calcula

It was with great interest that I read “Political Power of Iranian Hierocracies” by János Jany published in Comparative Civilizations Review. Writing about Iranian history is not an easy task because historical points of view have been highly politicized. Such is particularly the case when discussing the Pahlavi dynasty, particularly its founder, Reza Shah Pahlavi, and his successor, Mohammed Reza

In this chapter it is argued that the feminist pioneer Mary Wollstonecraft regarded moral agency as an exercise of freedom; a person who is unfree cannot perform acts that are moral in the proper sense. There are three aspects to this deprivation: first, the psychological effects of oppression; second, processes of deliberation and reasons for action, and third, the moral character of an act, such

Protein S is an anticoagulant protein that circulates in plasma in complex with C4b-binding protein; (C4BP) or in free form. Deficiency of protein S increases the risk of venous thrombosis. Measurement of free protein S, as compared to total levels, has been shown to be superior for prediction of protein S deficiency. We studied the effects of different handling protocols for an immuno- and a liga

We describe the derivation of a formalism in the context of the governing equations for two-dimensional water waves propagating over a flat bed in a flow with non-vanishing vorticity. This consists in providing a Hamiltonian structure in terms of two variables which are scalar functions.

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m