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Meta-analysis of gene-level tests for rare variant association.

The majority of reported complex disease associations for common genetic variants have been identified through meta-analysis, a powerful approach that enables the use of large sample sizes while protecting against common artifacts due to population structure and repeated small-sample analyses sharing individual-level data. As the focus of genetic association studies shifts to rare variants, genes

Influence of Soot Particle Aggregation on Time-Resolved Laser-Induced Incandescence Signals

Laser-induced incandescence (LII) is a versatile technique for quantitative soot measurements in flames and exhausts. When used for particle sizing, the time-resolved signals are analysed as these will show a decay rate dependent on the soot particle size. Such an analysis has traditionally been based on the assumption of isolated primary particles. However, soot particles in flames and exhausts a

FGF2 Specifies hESC-Derived Definitive Endoderm into Foregut/Midgut Cell Lineages in a Concentration-Dependent Manner.

Fibroblast growth factor (FGF) signaling controls axis formation during endoderm development. Studies in lower vertebrates have demonstrated that FGF2 primarily patterns the ventral foregut endoderm into liver and lung, whereas FGF4 exhibits broad anterior-posterior and left-right patterning activities. Furthermore, an inductive role of FGF2 during dorsal pancreas formation has been shown. However

Definition of Genetic Events Directing the Development of Distinct Types of Brain Tumors from Postnatal Neural Stem/Progenitor Cells.

Although brain tumors are classified and treated based upon their histology, the molecular factors involved in the development of various tumor types remain unknown. In this study, we show that the type and order of genetic events directs the development of gliomas, central nervous system primitive neuroectodermal tumors, and atypical teratoid/rhabdoid-like tumors from postnatal mouse neural stem/

Genetic variation in NEDD4L, an epithelial sodium channel regulator, is associated with cardiovascular disease and cardiovascular death.

We have previously shown that genetic variance in NEDD4L, a regulating protein of a sodium channel in the distal nephron, has been associated with marginally higher blood pressure and enhanced salt sensitivity. Here, we tested if the genetic NEDD4L variation previously associated with salt sensitivity is related to population blood pressure, incidence of cardiovascular disease (CVD) and mortality.

TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity.

The aggregation of α-synuclein plays a major role in Parkinson disease (PD) pathogenesis. Recent evidence suggests that defects in the autophagy-mediated clearance of α-synuclein contribute to the progressive loss of nigral dopamine neurons. Using an in vivo model of α-synuclein toxicity, we show that the PD-like neurodegenerative changes induced by excess cellular levels of α-synuclein in nigral

Genetic prediction of postpartum diabetes in women with gestational diabetes mellitus

Aims: To examine whether genetic variants that predispose individuals to type 2 diabetes (T2D) could predict the development of diabetes after gestational diabetes mellitus (GDM). Methods: 13 SNPs (FTO rs8050136, CDKAL1 rs7754840 and rs7756992, CDKN2A/2B rs10811661, HHEX rs1111875, IGF2BP2 rs1470579 and rs4402960, SLC30A8 rs13266634, TCF7L2 rs7903146, PPARG rs1801282, GCK rs1799884, HNF1A rs116928

Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts

Whether loci that influence fasting glucose (FG) and fasting insulin (FI) levels, as identified by genome-wide association studies, modify associations of diet with FG or FI is unknown. We utilized data from 15 US and European cohort studies comprising 51,289 persons without diabetes to test whether genotype and diet interact to influence FG or FI concentration. We constructed a diet score using s

Cell-based therapies for Parkinson disease-past insights and future potential.

Parkinson disease (PD) is characterized by loss of the A9 nigral neurons that provide dopaminergic innervation to the striatum. This discovery led to the successful instigation of dopaminergic drug treatments in the 1960s, although these drugs were soon recognized to lose some of their efficacy and generate their own adverse effects over time. Despite the fact that PD is now known to have extensiv

Menarche, menopause, and breast cancer risk: individual participant meta-analysis, including 118 964 women with breast cancer from 117 epidemiological studies

Background Menarche and menopause mark the onset and cessation, respectively, of ovarian activity associated with reproduction, and affect breast cancer risk. Our aim was to assess the strengths of their effects and determine whether they depend on characteristics of the tumours or the affected women. Methods Individual data from 117 epidemiological studies, including 118 964 women with invasive b

Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk

Background-Carotid intima-media thickness (cIMT) is a widely accepted marker of subclinical atherosclerosis. To date, large-scale investigations of genetic determinants of cIMT are sparse. Methods and Results-To identify cIMT-associated genes and genetic variants, a discovery analysis using the Illumina 200K CardioMetabochip was conducted in 3430 subjects with detailed ultrasonographic determinati

Niyongabo jean

Where Sustainable Agriculture means Agricultural Productivity? The case study of Gikongoro in Southwestern Rwanda By Jean Niyongabo E-mail: Jean.Niyongabo.557@student.lu.se Ngabojean2002@yahoo.fr Telephone: (+46)73 690 78 54 Advisor: Turaj S. Faran Department of Economic History Telephone: (+46) 46 224 474 E-mail: turaj.faran@ekh.lu.se Thesis Submitted in Partial Fulfillment for the Award of a Mas

https://www.lumes.lu.se/sites/lumes.lu.se/files/niyongabo_jean.pdf - 2026-06-07

Rapport vecka4 coss

Rapport vecka 4 (publicerad 2021-02-03) COVID Symptom Study Innehåll Bakgrund 2 Metod 2 Etiskt godkännande 4 Aktuell status 4 10 postnummerområden med högst uppskattad förekomst av symtomatisk covid-19 2 februari . . . 6 10 postnummerområden med lägst uppskattad förekomst av symtomatisk covid-19 2 februari . . . 8 Störst ökning senaste 7 dagarna . . . . . . . . . . . . . . . . . . . . . . . . . .

https://www.covid19app.lu.se/sites/covid19app.lu.se/files/rapport_vecka4_coss.pdf - 2026-06-07

Gnva11 litteratur vt15 3

Brevmall Genusvetenskapl iga ins t i tu t ionen Litteraturlista GNVA11, Genusvetenskap: fortsättningskurs 30 hp VT 2015 Delkurs 1: Teori de Beauvoir, Simone (2006). Det andra könet. Stockholm: Norstedts. (läses ca 300 sidor). Observera att endast Norstedts senaste vetenskapliga utgåva ska användas med Eva Gothlins förord. Finns i pocket. Butler, Judith (2007). Genustrubbel: Feminism och identitete

https://www.genus.lu.se/sites/genus.lu.se/files/gnva11_litteratur_vt15_3.pdf - 2026-06-07

Kor bil baseline

Microsoft Word - Kör bil A Frågeformulär Frågor till Dig som kör bil GÅS Gott åldrande i Skåne Så här fyller Du i frågeformuläret: De f lesta frågorna besvaras med ett kryss för det svars- alternativ som bäst stämmer in på Dig själv. I några fall kan Du kryssa i flera svarsalternativ på samma fråga. I så fall står det angivet direkt efter frågan. Om Du undrar över något i formuläret står vi gärna

https://www.geriatrik.lu.se/sites/geriatrik.lu.se/files/kor_bil_baseline.pdf - 2026-06-07

Final persian 190911

FINAL Persian 190911.pdf GRADUATE SCHOOL, FACULTY OF SOCIAL SCIENCES, LUND UNIVERSITY Persian Language Courses 
 Version 1.0, August 2019 For an always up-to-date online version, please visit the course site (check regularly for updates) Welcome! Welcome to the Autumn term’s courses in Persian Graduate School offers courses in modern Persian, which are open to all Graduate School students. The cou

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/final_persian_190911.pdf - 2026-06-07

Final persian 191213

FINAL Persian 191213.pdf GRADUATE SCHOOL, FACULTY OF SOCIAL SCIENCES, LUND UNIVERSITY Persian Language Courses 
 Version 1.0, January 2020 For an always up-to-date online version, please visit the course site (check regularly for updates) Welcome! Welcome to the Spring term’s courses in Persian Graduate School offers courses in modern Persian, which are open to all Graduate School students (and ot

https://www.graduateschool.sam.lu.se/sites/graduateschool.sam.lu.se/files/final_persian_191213.pdf - 2026-06-07

Leds buy greener 2017

Table of Contents LED’s Buy Greener Shedding light on sustainable procurement IIIEE | LUND UNIVERSITY Hippolyte de Bellefroid, Julie Emmrich, Wolfgang E. Haider, Dalia Hashweh, Caroline Heinz, Anita Lazurko, Antoine Lucic, Robin Mace-Snaith, Sahar Sajjad Malik, Shushant Vasisth, Yifei Zhao Partly funded by: Research by: Cover page designed by Dalia Hashweh This publication should be cited as: Inte

https://www.iiiee.lu.se/sites/iiiee.lu.se/files/leds_buy_greener_2017.pdf - 2026-06-07