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We simulate hadrons impinging on a homogeneous lead tungstate ((Formula presented.)) calorimeter using GEANT4 software to investigate how the resulting light yield and its temporal structure, as detected by an array of light-sensitive sensors, can be processed by a neuromorphic computing system. Our model encodes temporal photon distributions as spike trains and employs a fully connected spiking n
The birth prevalence of cleft lip and/or palate (CL/P) varies globally, and regional differences have previously been observed within Sweden. Updated data on CL/P birth prevalence is needed and has been requested nationally and internationally. This study investigated regional differences and temporal trends in the birth prevalences of CL/P and specific cleft subtypes across Sweden’s six health ca
Near infrared (NIR) fluorescence imaging has received significant attention. However, it remains challenging to develop NIR emitters with a high brightness. Herein, we report a supramolecular approach to formulate NIR fluorescent molecular nanoparticles from cationic NIR fluorophores and cyanostar receptors using their charge-by-charge packing in small-molecule ionic isolation lattices (SMILES). F
Background: Gaming disorder is a recently recognized psychiatric condition and a growing public health concern, particularly among adolescents. Despite this, there is limited research on what kind of treatment they need. Existing studies are mostly quantitative and offer limited insight into adolescents' lived experiences.Aim: The aim of this qualitative study is to explore how adolescent patientsBackground: Gaming disorder is a recently recognized psychiatric condition and a growing public health concern, particularly among adolescents. Despite this, there is limited research on what kind of treatment they need. Existing studies are mostly quantitative and offer limited insight into adolescents’ lived experiences. Aim: The aim of this qualitative study is to explore how adolescent patient
Background & aims: Alcohol consumption has been inversely associated with type 2 diabetes (T2D), but its influence on autoimmune diabetes is unclear. We investigated the risk of latent autoimmune diabetes in adults (LADA) and T2D in relation to alcohol intake and assessed if potential associations were modified by genetic susceptibility to diabetes. Methods: We used data from a case–control st
Knee osteoarthritis is a highly prevalent whole-joint disease that is associated with substantial morbidity. If step changes are to be made in the management of knee osteoarthritis, novel patient stratification approaches are needed to identify the most effective treatment for individual patients. Numerous methods for stratifying patients with knee osteoarthritis can be employed; clinical presenta
Biogenic ice-nucleating particles (INPs) can significantly impact mixed-phase clouds by enhancing precipitation and reducing albedo. As Arctic sea ice diminishes, the exposure of open ocean may increase aerosolization rates of marine bioaerosols and INPs. We investigated INP concentrations and microbial communities in ambient marine air, sea bulk water (SBW), and sea surface microlayer (SML) along
Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national res
BackgroundPatients with advanced ovarian cancer (AOC) who undergo primary and interval debulking surgery are often anemic at diagnosis, with iron deficiency being the most common cause. The aim was to investigate whether preoperative anemia and iron deficiency impact short-term recovery.MethodsThis retrospective cohort study included 262 patients with AOC who underwent surgery at Skane University
Young adults presenting with knee pain, instability, or both after twisting the knee during sports or at work are commonly seen in primary care. If the symptoms and injury history correspond with suspicion of a torn anterior cruciate ligament (ACL) or meniscal injury, sometimes in combination with positive findings on magnetic resonance imaging, patients are often referred for surgical treatment.
Epitaxially grown nanowires have shown promise for photovoltaic applications due to their nanophotonic properties. Moreover, the mechanical properties of nanowires can reduce crystallographic defect formation at interfaces to help enable new material combinations for photovoltaics. One material that stands to benefit from the nanowire morphology is zinc phosphide (Zn3P2), which, despite promising
Understanding three Dimensional (3D) fundamental processes is crucial for academic and industrial applications. Nowadays, X-ray time-resolved tomography, or tomoscopy, is a leading technique for in situ and operando 4D (3D+time) characterization. Despite its ability to achieve 1000 tomograms per second at large-scale X-ray facilities, its applicability is limited by the centrifugal forces exerted
Background: Medial plica is a structure with limited understanding of its pathology, but it may be related to the development of medial knee osteoarthritis (OA). We examined the association between medial plica and medial meniscus extrusion (MME), progression of MME, and the risk of early-stage knee OA development in middle-aged persons. Methods: A total of 340 subjects with tibiofemoral Kellgren–
The large-scale applications of anion exchange membrane water electrolysis (AEMWEs) and zinc–air batteries (ZABs) are observably limited by the lack of highly active, multifunctional, and industrially applicable electrocatalysts. In this work, we report a solvent-free rapid pyrolysis strategy that successfully prepares a composite material of Pt8V–V2O3 heterostructure supported on nitrogen-doped p
AimTo understand service users' experiences of their current mental health services and explore reflections on the Flexible Assertive Community Treatment (FACT) model and its role in future practice.MethodsA total of 17 experts participated in individual and dyadic in-depth interviews. A reflexive thematic analysis was performed on the participants' experiences of current mental health services anBackground: A person-centred and recovery-oriented approach is an integral part of modern mental health services founded on the experiential knowledge of service users. Their reflections as experts, grounded in their unique experience as service users, play a significant role in developing and improving the existing care. Experiential knowledge is therefore a means to enhance the relevance of rese
Aims Aortic valve calcification (AVC) is an underlying pathophysiological mechanism for aortic stenosis that is common in the elderly, but less is known in younger individuals. The aim was to study the prevalence and associated characteristics of AVC in a middle-aged general population. Methods and results Data were obtained from the Swedish CArdioPulmonary bioImage Study (SCAPIS) comprising 30 15
BACKGROUND AND OBJECTIVE: A post hoc analysis of TITAN evaluated the clinical benefit of apalutamide plus androgen-deprivation therapy (ADT) versus ADT alone in metastatic hormone-sensitive prostate cancer (mHSPC) with high disease burden. METHODS: Patients were assessed in subgroups of those with four to fewer than ten, ten to <20, or ≥20 bone metastases; with lung but not liver metastases; and w
BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related
The purpose of this narrative review is to provide an evidence-based update on management strategies for young adults with meniscal tears, based on two recent randomized controlled trials comparing a surgical vs. non-surgical treatment strategy for this patient group. The results from these trials suggests that exercise therapy is a viable treatment alternative for young adults with a meniscal tea
