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Recently, intense research activities have been focused on solution-processed hybrid lead halide perovskite semiconductors which are being developed for the solar-cell, light emitting diode (LED), and lasing applications. To optimize and fabricate a competitive perovskite-based optoelectronic device, the fundamental studies of the electronic structure, photo-generated carrier dynamics as well as t
So far, the semiconductor nanowire research area has mainly delivered results on growth procedures and related material properties. As the development lately has been successful in producing novel nanowire-based structures for optical or electronic applications, the time is ripe to review the device work that has been done and in some cases has produced devices ready for the market. In this chapte
Popular Abstract in Swedish Människan är uppbyggd av ett stort antal celler. För att kroppens olika organ ska kunna samverka och för att kroppen ska kunna fungera som en helhet, måste de olika cellerna kommunicera med varandra. Cellernas kommunikationssystem är uppbyggt av mottagare, s.k. receptorer, på de olika cellernas yta och signaler som skickas runt mellan cellerna. Receptorerna och signaleThe chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. Individuals continuously harbouring CCR5-restricted isolates still progress to AIDS. D
Hjärtinflammationsgruppen vid Lunds universitet undersöker immunologiska och inflammatoriska mekanismer som är involverade i hjärtsjukdomar. I djurmodeller utvecklar vi nya terapier riktade mot dessa mekanismer, som syftar till att minska hjärtskadan och förbättra hjärtfunktionen vid hjärtinfarkt, myokardit och septisk kardiomyopati. Vi bedriver också kliniska studier i stora patientkohorter för aThe Cardiac Inflammation Research Group at Lund University investigates immune and inflammatory mechanisms involved in cardiac disease. In animal models, we are developing novel therapies that target these mechanisms, aiming to reduce myocardial damage and improve cardiac function in myocardial infarction, myocarditis and septic cardiomyopathy. We are also performing clinical studies in large pati
Outer membrane vesicles (OMVs) play an important role in the persistence of Helicobacter pylori infection. Helicobacter OMVs carry a plethora of virulence factors, including catalase (KatA), an antioxidant enzyme that counteracts the host respiratory burst. We found KatA to be enriched and surface-associated in OMVs compared to bacterial cells. This conferred OMV-dependent KatA activity resulting
Under de senaste 100 åren har vi successivt minskat vår dagliga fysiska aktivitet. Eftersom vi är mindre vältränade, svagare och mer överviktiga har benägenheten att drabbas av sjukdomar som diabetes och hjärt- och kärlsjukdomar ökat. WHO rapporterar att 25% av vuxna inte uppfyller de globala rekommenderade nivåerna av fysisk aktivitet. Vår forskningsenhet är intresserad av att lära sig hur genetiDuring the last 100 years, we have gradually reduced our daily physical activity. As less fit, weaker, and fatter, we have become more prone to diseases like diabetes and cardiovascular disease. The WHO reports that one in four adults do not meet the global recommended levels of physical activity. Our research unit is interested in learning how genetic variation influences skeletal muscle function
Lungcancer är en vanlig tumörsjukdom med dåliga behandlingsresultat och den cancerform som skördar flest liv i Sverige och globalt. Rökning är den starkaste riskfaktorn för lungcancer men 10-15% av patienterna har aldrig rökt. Lungcancer är en heterogen sjukdom på molekylär nivå. För att förbättra diagnostiken, behandlingen och prognosen i lungcancer behövs en bättre förståelse av tumörspecifika fLung cancer, the leading cause of cancer death, is divided into histological subtypes with large differences in molecular alterations, clinical presentation, and patient outcome. By a combined clinical and molecular approach we focus on improving the molecular understanding of lung cancer and translate research findings into a clinical diagnostics. By characterization of the genomic, transcriptio
Epidemiology is the study of the distribution of diseases and disease promoting factors in the population. The cardiovascular epidemiology research group focuses on studies of cerebrovascular diseases (stroke) and heart diseases, such as myocardial infarction, heart failure or atrial fibrillation. The research is performed in well characterized population-based cohorts, with extensive information
We aim to identify novel interventions for prevention and treatment of diabetes-related cardiovascular disease (CVD). Our strategy is to identify genetic, endocrine and metabolic disturbances in humans which are causally related to disease development and are detectable many years before disease presents. We then test in both animals and in human intervention studies if manipulation of such molecu
