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Immunotherapy has shown limited success in acute myeloid leukemia (AML), indicating an incomplete understanding of the underlying immunoregulatory mechanisms. Here we identify an immune evasion mechanism present in 60% of AML cases, wherein primitive AML cells aberrantly express the lymphoid surface protein SLAMF6 (signaling lymphocyte activation molecule family member 6). Knockout of SLAMF6 in AM

Previous work has indicated a crucial role for the extracellular cysteine proteinase of Streptococcus pyogenes in the pathogenicity and virulence of this important human pathogen. Here we find that the purified streptococcal cysteine proteinase releases biologically active kinins from their purified precursor protein, H-kininogen, in vitro, and from kininogens present in the human plasma, ex vivo.

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Water body extraction (WBE) has attracted considerable attention in the field of remote sensing image analysis. Herein, we present an enhanced deep convolutional encoder-decoder (DCED) network (or Deep U-Net) specifically tailored to WBE from remote sensing images by applying superpixel segmentation and conditional random fields (CRFs). First, we preclassify the entire remote sensing image into th

Various clinical procedures, such as cardiovascular surgery or extracorporeal blood purification, involve systemic anticoagulation using heparin. High concentrations of circulating heparin require neutralization due to possible serious bleeding complications. The intravenous administration of the heparin antagonist protamine sulfate is routinely clinically performed, but is frequently associated w

Poly (ADP-Ribose) Polymerase 14 (PARP14) is an ADP-ribosyltransferase, an enzyme whose catalytic activity is to transfer ADP ribose (ADPr) to a target molecule, utilizing its substrate NAD+. PARP14 has been discovered to partake in the development of different kinds of cancers such as multiple myeloma, B-cell lymphoma and sarcoma, which has led to the interest of using PARP14 as a drug target for

Lead-free halide double perovskites have gathered wide scientific interest since they are environmentally friendly and stable. However, compared to the lead perovskites, their optoelectronic properties are compromised. Herein we report a series of bulk lead-free mixed Bi-In halide double perovskites: Cs2AgBi1−xInxCl6 (0

It would be difficult to argue that an uneducated society in today’s world would persevere beyond that of an educated; education has become an essential key to survival. It has been considered “a foundational driver of development which furthermore helps create self-reliance, economic growth, direction to better health and even democratic societies” (Usaid.gov, 2019). If one considers that claim a

Fluorescent probes based on photoinduced electron transfer (PET) quenching of long lifetime triangulenium fluorophores have found multiple applications. For such probes a successful design relies on the right balance between the rate of PET quenching and fluorescence. In a series of ADOTA (A) and DAOTA (D) triangulenium fluorophores appended with aniline-like quencher moieties, we have investigate

Recent outlooks suggest a long-term relevance of internal combustion engines for both power generation and transportation. Nonetheless, stringent pollutant reduction requirements combined with new CO2 mandates draws a challenging scenario, requiring intensive research and development activities to develop and optimize combustion modes to fulfill these requirements. Among the recent advancements, t

GLOBAL ENVIRONMENTAL CHANGE FROM A GEOLOGICAL PERSPECTIVE,15 ECTS CREDITS Human impact on Earth’s ecosystems has never been greater than today, and it has become clear that humanity now also has an influence Earth’s climate system. In what ways and for how long have we had an impact on the global environment, and how can geological data and models be used for distinguishing this impact from the ev

https://www.geology.lu.se/education/programme-structure/geon09 - 2026-07-11

By mimicking embryonic development of the hematopoietic system, we have developed an optimized in vitro differentiation protocol for the generation of precursors of hematopoietic lineages and primitive hematopoietic cells from human embryonic stem cells (ES) and induced pluripotent stem cells (iPS). Factors such as cytokines, extra cellular matrix components, and small molecules, as well as the te