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Smooth muscle cell (SMC)-specific deletion of transforming growth factor beta (TGF-beta) signaling would help elucidate the mechanisms through which TGF-beta signaling contributes to vascular development and disease. We attempted to generate mice with SMC-specific deletion of TGF-beta signaling by mating mice with a conditional ("floxed") allele for the type 11 TGF-beta receptor (tgfbr2(flox)) to
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Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly
Psykisk hälsa och psykiatrisk hälso- och sjukvårdsforskning
Vår forskning fokuserar på personer med allvarlig och långvarig psykisk sjukdom och deras livssituation i samhället. De omfattande omstruktureringarna av det psykiatriska vård- och stödsystemet har inneburit långtgående krav på en utveckling av nya kunskapsbaserade vård- och stödinsatser. Detta för att främja hälsa och ett meningsfullt liv i samhället för den här gruppen och deras anhöriga. Många Our research focuses on individuals with severe and long-lasting mental illness and their situation in society. The extensive restructuring of the mental health and support systems towards community-based service systems brings forth far-reaching requirements for developing new knowledge-based health and support interventions. Such efforts are needed to favour and support health and a meaningful l