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Liquid biopsy allows assessment of multiple analytes, providing temporal information with potential for improving understanding of cancer evolution and clinical management of patients. Although liquid biopsies are intensely investigated for prediction and response monitoring, preanalytic variables are of primary concern for clinical implementation, including categories of collection method and sam
Objective: Detailed analysis of hematological manifestations (HM) in systemic lupus erythematosus (SLE) are limited and their clinical impact on disease remain obscure. Here, we aimed to decipher factors associated with different hematological abnormalities in SLE patients and to assess their impact on disease related outcomes. Methods: A dataset (GIPT) originating from SLE patients of six Europea
Background: Inferior placement of a femoral stem is predictive for early loosening and failure, but does restoration of the original hip anatomy benefit the function and survival of a total hip replacement? Methods: Seventy-five patients with primary unilateral hip osteoarthritis operated with an uncemented anatomical stem were randomized for either standard or modular stems. We used 50 ABG II ste
Since spring 2019 an experimental setup consisting of an electron spectrometer and an ion time-of-flight mass spectrometer for diluted samples has been available for users at the FinEstBeAMS beamline of the MAX IV Laboratory in Lund, Sweden. The setup enables users to study the interaction of atoms, molecules, (molecular) microclusters and nanoparticles with short-wavelength (vacuum ultraviolet an
Background: Late effects induced by radiotherapy (RT) are of great concern for mediastinal Hodgkin’s lymphoma (HL) patients and it is therefore important to reduce normal tissue dose. The aim of this study was to investigate the impact on the normal tissue dose and target coverage, using various combinations of intensity modulated proton therapy (IMPT), volumetric modulated arc therapy (VMAT) and
Current techniques for visualising geospatial Linked Data are limited in terms of multiple representation, which has been studied for decades by cartographers and considered as a prerequisite for deriving appropriate geovisualisation applications. In order to alleviate this issue, this paper presents a work in progress, in which the multiple representation geospatial data are released as Linked Da
Objectives To assess whether chronic kidney disease of unknown aetiology (CKDu) is present in India and to identify risk factors for it using population-based data and standardised methods. Design Secondary data analysis of three population-based cross-sectional studies conducted between 2010 and 2014. Setting Urban and rural areas of Northern India (states of Delhi and Haryana) and Southern India
The Barnahus model was launched in Iceland in 1998, and it subsequently spread to all the Nordic countries. It is an interagency, co-located model for working with cases of violence and abuse against children that addresses two vital concerns of welfare societies: to process cases through the legal system and to offer support and treatment to victims. The model is currently recommended as a best-p
A search for four-top-quark production, tttt, is presented. It is based on proton-proton collision data with a center-of-mass energy s=13 TeV collected by the ATLAS detector at the Large Hadron Collider during the years 2015 and 2016, corresponding to an integrated luminosity of 36.1 fb-1. Data are analyzed in both the single-lepton and opposite-sign dilepton channels, characterized by the presenc
3-Methyl-1,2,3-butanetricarboxylic acid (MBTCA) is a secondary organic aerosol and can be used as a unique emission marker of biogenic emissions of monoterpenes. Seasonal variations and differences in vegetation cover around the world may lead to low atmospheric MBTCA concentrations, in many cases too low to be measured. Hence, an important
The Global Stratotype Section and Point (GSSP) defining the base of the Jurassic System Lower Jurassic Epoch and Hettangian Stage is situated at the Kuhjoch pass, Karwendel Mountains, Northern Calcareous Alps, Austria (47°29'02"N/11°31'50"E). The Triassic-Jurassic (T-J) boundary is exposed at Kuhjoch West and at Kuhjoch East, and corresponds to the first occurrence (FO)
Stimulated by a recent controversy regarding pressure drops predicted in a giant aneurysm with a proximal stenosis, the present study sought to assess variability in the prediction of pressures and flow by a wide variety of research groups. In phase I, lumen geometry, flow rates, and fluid properties were specified, leaving each research group to choose their solver, discretization, and solution s
Leptospirosis is a zoonotic disease found wherever human is in direct or indirect contact with contaminated water and environment. Considering the increasing number of cases of this disease in the northern part of Iran, identifying areas characterized by high disease incidence risk can help policy-makers develop strategies to prevent its further spread. This study presents an approach for generati
In the remedial phase following an accidental radioactive release, it is important that soil decontamination measures are carried out on the areas that contribute most to the radiation dose. In this study, the newly developed concept of isodose lines was applied to the area around typical Swedish dwellings to identify these areas. The influence of the most common building materials in Sweden, wood
Purpose: The aim of the study was to compare overall survival (OS) and disease-free survival (DFS) after open and robotic radical hysterectomy for early-stage cervical cancer. Patients and methods: This was a nationwide population-based cohort study on all women with cervical cancer stage IA1-IB of squamous, adenocarcinoma or adenosquamous histological subtypes, from January 2011 to December 2017,
