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MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human brain development remains largely unexplored. Here, we provide a comprehensive analysis of miRNA expression of regionalized neural progenitor cells derived from human embryonic stem cells and human foetal brain. We found miR-92b-3p and miR-1

TP53 mutations in the absence of 17p-deletion correlate with rapid disease progression and poor survival in chronic lymphocytic leukemia (CLL). Herein, we determined the TP53 mutation frequency in 268 newly diagnosed CLL patients from a population-based material. Overall, we detected TP53 mutations in 3.7% of patients (n = 10), where 7/10 cases showed a concomitant 17p-deletion, confirming the hig

Calibration of network nodes using only time differences of arrival (TDOA) measurements opens up for interesting applications in wireless ad-hoc sensor networks, e.g. finding the positions of cell phones by only ambient sounds or radio. We present two novel approaches for the problem of self-calibration of network nodes using only TDOA when both receivers and transmitters are unsynchronized. We co

The mechanism of atomic and molecular ionization in intense, ultra-short laser fields is a subject which continues to receive considerable attention. An inherent difficulty with techniques involving the tight focus of a laser beam is the continuous distribution of intensities contained within the focus, which can vary over several orders of magnitude. The present study adopts time of flight mass s

Popular Abstract in Swedish Multikonjugerad Adaptiv Optik för Astronomiska Teleskop 1. Atmosfärisk turbulens Allt sedan man på 1600-talet började bruka optiska instrument inom astronomin, för att understödja det mänskliga ögat då man beskådade stjärnhimlen, har astronomer strävat efter att bygga allt större och bättre teleskop för att kunna se längre ut i rymden och skönja allt ljussvagare objekt.This work analyses several aspects of multi-conjugate adaptive optics (MCAO) for astronomy. The research ranges from fundamental and technical studies for present-day MCAO projects, to feasibility studies of high-order MCAO instruments for the extremely large telescopes (ELTs) of the future. The first part is an introductory exposition on atmospheric turbulence, adaptive optics (AO) and MCAO, esta

Popular Abstract in Swedish Människor (och andra arter) har en grundläggande förmåga att anpassa sig till och lära sig hur omgivningen är strukturerad. Ofta lär vi oss struktur indirekt, utan att direkt och avsiktligt studera strukturen ifråga. Klassiska vardagsexempel på tämligen oavsiktlig strukturinlärning är språkinlärning, utveckling av musikaliska preferenser, inlärning av sociala regler, ocPeople can become sensitive to the general structure of different parts of the environment, often without studying that general structure directly, but through being incidentally exposed to instances that conform to the structure. When such learning proceeds unintentionally and gives rise to knowledge that is difficult to verbalize it is often referred to as implicit learning. One of the most comm

It is shown how tilt anisoplanatism in laser-supported multi-conjugatedadaptive optics (MCAO) systems can be a) predicted from a prioriknowledge, b) compensated using additional natural guide stars (NGS),and c) estimated in real time from control loop data to allow PSFretrieval. As a consequence of the problems associated with retrievingatmospheric tip and tilt from laser guide star (LGS) measurem

Fine particle emissions were measured at two commercial grate fired boilers operating on moist fuel residues. The aim of this study was to characterize fine particle emissions with a view to pinpoint parameters influencing the emissions. Additionally effectiveness of used flue gas cleaning techniques was assessed. The results show that large quantities of fine particles are emitted to the atmosphe

We take a logical approach to threshold models , used to study the diffusion of e.g. new technologies or behaviors in social net-works. In short, threshold models consist of a network graph of agents connected by a social relationship and a threshold to adopt a possibly cascading behavior. Agents adopt new behavior when the proportion of their neighbors who have already adopted it meets the thresh

Popular Abstract in Swedish Cancer är ett laddat ord, och för de flesta av oss är cancern inte längre bort än hos en nära släkting eller vän. Trots den gemensamma benämningen, är cancer är inte bara en sjukdom, utan ca 200 olika som alla har gemensamt att cellerna börjar dela sig okontrollerat. Cancer är väldigt vanligt och uppskattningsvis kommer var tredje person att drabbas av cancer under sin Early diagnosis and reliable prognosis and treatment prediction of breast cancer will ultimately lead to a decreased mortality rate. This can be achieved by identification of prognostic and treatment predictive biomarkers, and by understanding the mechanisms behind early changes in the breast. The cell cycle is a closely controlled process, involving multiple components with regulation on several

The effort to electrify society has in recent years resulted in major changes in the transportation sector. Charging time remains a challenge in several applications such as transportation and heavy machinery. A proposed solution that shortens the energy replenishment time and adds flexibility in loading the grid is to battery-swapping: exchanging the depleted battery for a fully charged one. In s

We investigated the role of cultural experience in the search advantage for happy faces. European British participants living in the UK, Asian Japanese participants living in Japan, and Asian Japanese participants living in the UK, were required to search for a happy or an angry face target against a background of neutral facial expressions, using Asian Japanese and European American faces. Result

Sex-limited morphs can provide profound insights into the evolution and genomic architecture of complex phenotypes. Inter-sexual mimicry is one particular type of sex-limited polymorphism in which a novel morph resembles the opposite sex. While inter-sexual mimics are known in both sexes and a diverse range of animals, their evolutionary origin is poorly understood. Here, we investigated the genom

Background People living with serious respiratory illness experience a high burden of symptoms. This review aimed to determine whether multicomponent services reduce symptoms in people with serious illness related to respiratory disease. Methods Electronic databases were searched to identify randomised controlled trials (RCTs) evaluating multicomponent services that enrolled patients due to sympto