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Popular Abstract in Swedish Information om smärta, klåda och temperaturförändringar förmedlas till centrala nervsystemet av tunna nervfibrer som leder nervimpulser relativt långsamt. Information om beröring av huden förmedlas istället av grova och snabbt ledande nervfibrer. Det är välkänt att olika känselkvaliteter kan interagera med varandra på olika nivåer i centrala nervsystemet. Vanlig berörinIt is known that stimulation of thin nerve afferents can inhibit itch and pain and that the nociceptive systems have a detailed topographical organisation, with subsystems exhibiting specific excitatory and inhibitory receptive fields. On this basis, a new technique was developed, termed Cutaneous Field Stimulation (CFS), that electrically stimulates thin nerve fibers innervating specific skin fie

Popular Abstract in Swedish Strålningsterapi är en viktig metod för att behandla många cancertyper och man söker konstant efter olika sätt att förbättra användningen av joniserande strålning vid behandling. Radiobiologisk forskning för cancerterapi söker att förbättra vår förståelse för hur joniserande strålning verkar på olika livsformer. Idag finns det många sätt att utröna en behandlings inverkFor the development of a Single–Ion Hit Facility (SIHF) for living cells irradiation at the Lund Ion Beam Analysis facility (LIBAF), newly developed pre-cell detectors have been investigated. These detectors can determine the number of ions reaching the sample. Central to the thesis is their fabrication and characterization. Two different detectors ’ Design A and Design B’ were fabricated with thi

This study uses the Swedish register of prescribed drugs, merged with the Survey of Living Conditions (the ULF), to analyze the socioeconomic gradient in drug utilization. It finds a significant education gradient (but no income gradient) in individual drug utilization. Whereas the education gradient for men is quantitative in its orientation (education affects number of drugs used), the gradient

In Australia a national public/private telematics framework has been established, which is administered by Transport Certification Australia (TCA). The first application was the Intelligent Access Program (IAP), which has enabled several road transport reforms by managing infrastructure risks associated with the operation of extra heavy vehicle configurations. The paper uses the IAP to demonstrate

Popular Abstract in Swedish Inflammerat brosk i halsen. Rethosta eller andningsbesvär. Autoimmuna sjukdomar uppstår när immunförsvaret angriper och bryter ner den egna kroppens vävnader. Då kroppen infekteras av bakterier eller virus är immunförsvarets ökade aktivitet däremot en normal skyddsmekanism. Exempel på vanligt förekommande autoimmuna sjukdomar är diabetes, reumatoid artrit (RA) och multRelapsing polychondritis (RP) and rheumatoid arthritis (RA) are autoimmune diseases where an inappropriate immune response destroys cartilage. In RP, the ears, larynx, nose and joints are affected, while the most prominent sign of RA is arthritis. For ethical reasons many experiments can not be performed in man, and consequently animal models are needed. To investigate the complexity of the tissu

Various papers described mesh morphing techniques for computational biomechanics, but none of them provided a quantitative assessment of generality, robustness, automation, and accuracy in predicting strains. This study aims to quantitatively evaluate the performance of a novel mesh-morphing algorithm. A mesh-morphing algorithm based on radial-basis functions and on manual selection of correspondi

A strategy for feedback control of the glucose feed rate in cultivations of E.coli is discussed. By making probing pulses in the feedrate it is possible to detect and avoid undesirable by-productformation using a standard dissolved oxygen sensor. The feasibility of an improved and simplified probing algorithm is demonstrated by simulations as well as laboratory-scale experiments.

This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. In this thesis, the technique is used

Ethanol production by the yeast Saccharomyces cerevisiae from dilute acid lignocellulose hydrolyzate was studied with the aim to improve fuel ethanol production. Specifically, the problem of inhibition was addressed. Lignocellulose hydrolyzate contains not only sugars, but also several compounds, such as furfural and 5-hydroxymethyl furfural (HMF), which can inhibit yeast growth and ethanol produc

Modern military multi-role combat aircrafts need an emergency power system (EPU) to maintain back-up power supply for all normal and degraded flight modes. The reason for this requirement is that modern combat aircrafts are designed with built-in relaxed or negative stability. Inability of the Flight Control System to perform continuous, corrective control surface actuation, due to loss of power

Two different sensitive microtitre-plate based enzyme immunoassays were developed and evaluated for determination of the model drug compound, budesonide, in blood plasma. In the first approach, high sensitivity was obtained by using amperometric detection in a flow injection system for determination of the enzyme product p-aminophenol. The high sensitivity in the second approach was obtained using

Ethanol can be produced from lignocellulose by first hydrolysing the material to sugars, and then fermenting the hydrolysate with the yeast Saccharomyces cerevisiae. Hydrolysis using dilute sulphuric acid has advantages over other methods, however, compounds which inhibit fermentation are generated during this kind of hydrolysis. The inhibitory effect of aliphatic acids, furans, and phenolic compo