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Soot, or black carbon (BC), aerosol is a major climate forcer with severe health effects. The impacts depend strongly on particle number concentration, size and mixing state. This work reports on two field campaigns at nearby urban and rural sites, 65gkm apart, in southern Sweden during late summer 2018. BC was measured using a single-particle soot photometer (SP2) and Aethalometers (AE33). Differ

Iron-centered N-heterocyclic carbene compounds have attracted much attention in recent years due to their long-lived excited states with charge transfer (CT) character. Understanding the orbital interactions between the metal and ligand orbitals is of great importance for the rational tuning of the transition metal compound properties, e.g., for future photovoltaic and photocatalytic applications.

ObjectiveDevelopment of an AI tool to assess velopharyngeal competence (VPC) in children with cleft palate, with/without cleft lip.DesignInnovation of an AI tool using retrospective audio recordings and assessments of VPC.SettingTwo datasets were used. The first, named the SR dataset, included data from follow-up visits to Skåne University Hospital, Sweden. The second, named the SC + IC dataset, w

OBJECTIVES: Asphalt is frequently used as road pavement and consists of bitumen as a binder, and fillers. Bitumen consists of a complex mixture of hydrocarbons, where a minor component is polycyclic aromatic hydrocarbons (PAHs). Many PAHs are classified as carcinogenic to humans. Bitumen fumes from road paving have been classified as possibly carcinogenic. Paving and milling are open processes gen

The Aerosol, Clouds and Trace Gases Research Infrastructure (ACTRIS) officially became the 33rd European Research Infrastructure Consortium (ERIC) on 25 April 2023 with the support of 17 founding member and observer countries. As a pan-European legal organization, ACTRIS ERIC will coordinate the provision of data and data products on short-lived atmospheric constituents and clouds relevant to clim

Huntington's disease (HD) is a neurodegenerative disorder caused by CAG expansions in the huntingtin (HTT) gene. Modelling Huntington's disease is challenging, as rodent and cellular models poorly recapitulate the disease as seen in aging humans. To address this, we generated induced neurons (iNs) through direct reprogramming of human skin fibroblasts, which retain age-dependent epigenetic charact

Firefighters are occupationally exposed to a large number of toxic compounds (IARC 2010). The occupational exposure of firefighters has been classified as potentially carcinogenic (class 2B, IARC; (Straif K. et al. 2007)). Poorly quantified emission factors and low understanding of when various aerosol emissions are likely to form during a fire event (initiation, combustion, extinguishing) inhibit

BACKGROUND: Conventional dosages of cytostatics in mg/m2 will cause marked variations in systemic exposure, resulting in over- and under-treatment, at least with respect to side effects.PATIENTS AND METHODS: We are conducting a randomized adjuvant study for breast cancer patients younger than 60 years of age with > or = 70% risk of recurrence within five years. The first 89 consecutive patients wh

Immunotherapies with antibody-drug-conjugates (ADC) and CAR-T cells, targeted at tumor surface antigens (surfaceome), currently revolutionize clinical oncology. However, target identification warrants a better understanding of the surfaceome and how it is modulated by the tumor microenvironment. Here, we decode the surfaceome and endocytome and its remodeling by hypoxic stress in glioblastoma (GBM

Background Dyspnoea is one of the emergency department’s (ED) most common and deadly chief complaints, but frequently misdiagnosed and mistreated. We aimed to design a diagnostic decision support which classifies dyspnoeic ED visits into acute heart failure (AHF), exacerbation of chronic obstructive pulmonary disease (eCOPD), pneumonia and “other diagnoses” by using deep learning and complete, uns

Background: The observation of differences in the way apparently similar patients are treated from one health care setting to another, i.e., practice variation, have been recognized in numerous studies. The variations across the health care settings have been shown to exist for different outcomes. However, any measurement of any system will reveal some form of variation and this normal inevitable

The use of acoustic forces to manipulate particles or cells at the microfluidic scale (i.e. acoustophoresis), enables non-contact, label-free separation based on intrinsic cell properties such as size, density and compressibility. Acoustophoresis holds great promise as a cell separation technique in several research and clinical areas. However, it has been suggested that the force acting upon cell

After years of secretive, back-door negotiations, the Trans-Pacific Partnership (TPP) was finally revealed to the public on November 5, 2015. While the TPP has been regarded by some as the “gold standard” for free trade agreements in the twenty-first century, a wide spectrum of political opposition has continued formed around the deal. This paper builds on the growing body of critical scholarship

PURPOSE: To assess whether higher plasma 25-hydroxyvitamin D [25(OH)D] is associated with improved outcomes in colon cancer and whether circulating inflammatory cytokines mediate such association.EXPERIMENTAL DESIGN: Plasma samples were collected from 1,437 patients with stage III colon cancer enrolled in a phase III randomized clinical trial (CALGB/SWOG 80702) from 2010 to 2015, who were followed

Human-bacterial interactions play a crucial role in several essential aspects of life. Here, we describe how a secreted protein from the skin commensal Cutibacterium acnes, RoxP, functions as a sacrificial redox effector molecule that facilitates beneficial interactions with its human host by counteracting oxidative stress and reducing stress-induced inflammation. Using a combination of structural