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This opinion piece takes Google's response to the so-called COVID-19 infodemic, as a starting point to argue for the need to consider societal relevance as a complement to other types of relevance. The authors maintain that if information science wants to be a discipline at the forefront of research on relevance, search engines, and their use, then the information science research community needs
Inverse problems are important in quantum mechanics and involve such questions as finding which potential give a certain spectrum or which arrangement of atoms give certain properties to a molecule or solid. Inverse problems are typically very hard to solve and tend to be very compute intense. We here show that neural networks can easily solve inverse problems in quantum mechanics. It is known tha
Background: The signal transducer and activator of transcription 3 (STAT3) pathway is observed to be constitutively activated in several malignancies including prostate cancer (PCa). In the present study, we investigated the expression of total STAT3 (tSTAT3) and two forms of activated phosphorylated STAT3 (pSTAT3 727 and pSTAT3 705 ) in tissue microarrays (TMA) of two cohorts of localized horm
BACKGROUND The association between neighborhood deprivation and mortality is well established, but knowledge about whether deprivation is best assessed regionally or nationally is scarce. OBJECTIVE The present study aims to examine whether there is a difference in results when using national and county-specific neighborhood deprivation indices and whether the level of urbanization modifies the ass
A hallmark of adult hematopoiesis is the continuous replacement of blood cells with limited lifespans. While active hematopoietic stem cell (HSC) contribution to multilineage hematopoiesis is the foundation of clinical HSC transplantation, recent reports have questioned the physiological contribution of HSCs to normal/steady-state adult hematopoiesis. Here, we use inducible lineage tracing from ge
We herein outline the rationale for a Swedish cohort consortium, aiming to facilitate greater use of Swedish cohorts for world-class research. Coordination of all Swedish prospective population-based cohorts in a common infrastructure would enable more precise research findings and facilitate research on rare exposures and outcomes, leading to better utilization of study participants’ data, better
BACKGROUND: Although rare in the general population, highly penetrant germline mutations in CDKN2A are responsible for 5-40% of melanoma cases reported in melanoma-prone families. We sought to determine whether MELPREDICT was generalizable to a global series of melanoma families and whether performance improvements can be achieved.METHODS: 2,116 familial melanoma cases were ascertained by the inte
Chronic Obstructive Pulmonary Disease (COPD) is often caused by smoking and other stressors. This causes oxidative stress, which induces numerous changes on both the transcriptome and proteome of the cell. We aimed to examine if the endomembrane pathway, including the endoplasmic reticulum (ER), Golgi, and lysosomes, was disrupted in fibroblasts from COPD patients as opposed to healthy ever-smoker
Background. Epidemiological studies indicate that physical activity reduces the risk of cancer. Physical inactivity or sedentary behavior, has recently been suggested as a risk factor independent of physical activity level. Breast and endometrial cancer incidence have both been associated with physical activity, and endometrial cancer incidence with physical inactivity/sedentary behavior. The purp
Habitat loss and population fragmentation pose severe threats to biodiversity and the survival of many species. Population isolation and the decline in effective population size lead to increased genetic drift and inbreeding. In turn, this reduces neutral diversity, and it also affects the genetic load of deleterious mutations. Here, we analyse the effect of such genomic erosion by designing a spa
BACKGROUND: Contact allergy rates of linalool and limonene hydroperoxides (HPs) have increased.OBJECTIVES: To demonstrate the patterns of simultaneous positive patch test (PT) reactions and prevalences of multiple contact allergies (MCAs) in patients with contact allergy to linalool and/or limonene HPs.METHODS: A retrospective analysis of consecutive dermatitis patients in 2015-2020 was performed.
Expansions of innovation policies have been paralleled with an increase in the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neExpansions of innovation policies have been paralleled with an increasein the evaluations of such policies. Yet, there are few systematic evaluations of how such evaluations are conducted, by whom, and their overall conclusions. We analyze 110 evaluations of innovation policy in Sweden from 2005 to 2019. Our findings show that the majority of these evaluations are positive, about one-third are neu
Now extinct, the aurochs (Bos primigenius) was a keystone species in prehistoric Eurasian and North African ecosystems, and the progenitor of cattle (Bos taurus), domesticates that have provided people with food and labour for millennia1. Here we analysed 38 ancient genomes and found 4 distinct population ancestries in the aurochs—European, Southwest Asian, North Asian and South Asian—each of whic
Mexico has experienced the dramatic escalation of crime and violence in an organized form since the 1990s, and have also witnessed the highest number of homicides in the last ten years. It has adversely affected the national security, economic growth and social development with an especially detrimental effect on youth in Mexico. This study examines the direct and indirect impacts of drug trade-re
Behandling av personuppgifter, vilket undersöks i denna uppsats, sker i den offentliga och privata sektorn, och i organisationer av alla storlekar. Personuppgiftsbehandlingar förekommer i varje gren av en organisation och hos alla olika aktörer, inom så spridda områden som rättsväsendet eller en frisörsalong. Mer specifikt syftar denna uppsats till att studera definitionen av "behandling"Personal data processing, as will be examined in this thesis, occurs in the public and the private sectors, in organisations of every size. It occurs in every branch of an organisation and by all different actors, be it law-enforcement or a hairdresser saloon. More specifically this thesis aims to study the definition of ‘processing’ and attempts to highlight the features and characterisation of i
Germline mutations in the tumour suppressor gene CDKN2A occur in 5-20% of familial melanoma cases. A single founder mutation, p.Arg112dup, accounts for the majority of CDKN2A mutations in Swedish carriers. In a national program, carriers of p.Arg112dup mutation have been identified. The aim of this study was to assess cancer risks in p.Arg112dup carriers and their first degree relatives (FDRs) and
The public health impact of population-based mammography screening programs depends on high participation rates. Thus, monitoring participation rates, as well as understanding and considering the factors influencing attendance, is important. With the goal to acquire information on the appropriate level of intervention for increasing screening participation our study aimed to (1) examine whether, o
En aktieägare i ett tillgångsägande aktiebolag, som vill få egenhändig kontroll över en tillgångs avkastningsförmåga, har idag två möjliga vägar att välja mellan för att uppnå sitt mål. Denne kan förvärva aktier i bolaget eller förvärva, direkt eller indirekt, själva tillgången. Beroende på vilken väg som väljs kommer aktieägaren stöta på olika typer av hinder. Denna uppsats syftar till att redogöA shareholder in an asset holding company, who wishes to gain direct control over the asset's capacity to produce profit, currently has two possible paths to choose from in order to achieve his or her goal. He or she can either acquire shares in the company or directly or indirectly acquire the asset itself. Depending on the chosen path, the shareholder will encounter different types of obstac
