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Infant acute lymphoblastic leukemia (ALL) with KMT2A-gene rearrangements (KMT2A-r) have few mutations and a poor prognosis. To uncover mutations that are below the detection of standard next-generation sequencing (NGS), a combination of targeted duplex sequencing and NGS was applied on 20 infants and 7 children with KMT2A-r ALL, 5 longitudinal and 6 paired relapse samples. Of identified nonsynonym

Acute myeloid leukemia (AML) is initiated and propagated by leukemia stem cells (LSCs), a self-renewing population of leukemia cells responsible for therapy resistance. Hence, there is an urgent need to identify new therapeutic opportunities targeting LSCs. Here, we performed an in vivo CRISPR knockout screen to identify potential therapeutic targets by interrogating cell surface dependencies of L

Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape of TNBC. By analyzing tumor methylome profiles and accounting for the genomic context of CpG methylation, we divide TNBC into two epigenetic subtypes corresponding to a Basal and a non-Basal group, in which characteristic transcrip

BACKGROUND: The diagnostic role of signal-averaged ECG (SAECG) in arrhythmogenic right ventricular cardiomyopathy (ARVC) has lately been questioned. We assessed the value of SAECG-derived late ventricular potentials (LP) in ARVC diagnosis and its association with disease manifestations.METHODS AND RESULTS: Patients with definite ARVC diagnosis or genotype-positive family members who underwent SAEC

We characterize the selection function of RAdial Velocity Experiment (RAVE) using 2 Micron All Sky Survey (2MASS) as our underlying population, which we assume represents all stars that could have potentially been observed.We evaluate the completeness fraction as a function of position, magnitude and colour in two ways: first, on a field-by-field basis, and second, in equal-size areas on the sky.

Health applications have increasingly been used to improve physical, mental and social well-being. Chronic pain (CP) is defined as pain that lasts for a period of three months and causes sporadic or constant discomfort. In Portugal, the treatments for this type of pain are almost exclusively pharmacological and with known limited effects. Endowing patients with self-management skills, will help th

The endogenous chemokines CCL19 and CCL21 signal via their common receptor CCR7. CCL21 is the main lymph node homing chemokine, but a weak chemo-attractant compared to CCL19. Here we show that the 41-amino acid positively charged peptide, released through C-terminal cleavage of CCL21, C21TP, boosts the immune cell recruiting activity of CCL21 by up to 25-fold and the signaling activity via CCR7 by

SVENSKANS BESKRIVNING 34 onsdag 22 oktober 2014 09.00 – 12.30 - 13.00 13.00 - 14.00 14.00 - 14.15 14.15 - 14.45 14.45 - 15.15 15.15 - 15.45 15.45 - 16.15 16.15 - 16.45 Ordförande: Björn Melander Ordförande: Ylva Byrman Ordförande: Anna W Gustafsson Ordförande: Andreas Nord Registreringen öppnar utanför Humanisthusets hörsal på Språk- och Litteraturcentrum. Konferensen öppnas av Lynn Åkesson, dekan

https://konferens.ht.lu.se/fileadmin/_migrated/content_uploads/Program231014.pdf - 2026-05-28

Utbildningsplan Naturvetenskapligt kandidatprogram Naturvetenskapliga fakulteten NGNAT, Naturvetenskapligt kandidatprogram, 180 högskolepoäng Sciences, 180 credits Program utan akademiska förkunskapskrav och med slutlig examen på grundnivå / First cycle degree programme not requiring previous university study Beslutsuppgifter Utbildningsplanen är fastställd av Naturvetenskapliga fakultetsstyrelsen

https://www.geologi.lu.se/sites/geologi.lu.se/files/2021-11/NGNAT.pdf - 2026-05-29

https://www.astro.lu.se/sites/astro.lu.se/files/2024-06/GalacticN-bodySimulations.pdf - 2026-05-29

Disease susceptibility mapping using spatial modeling techniques Author: Mohammadreza Rajabi Supervisors: Ali Mansourian , Petter Pilesjo GIS Center ,Department of Physical Geography and Ecosystem Science Lund University September, 2015 Disease susceptibility mapping using spatial modeling techniques ii Table of Contents 1- Introduction .............................................................

https://www.nateko.lu.se/sites/nateko.lu.se/files/mohammadreza-rajabi-first_year_seminar-17-08-2015-v4.pdf - 2026-05-29

Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector HUMAN GENE THERAPY 15:934–944 (October 2004) © Mary Ann Liebert, Inc. Regulated Delivery of Glial Cell Line-Derived Neurotrophic Factor into Rat Striatum, Using a Tetracycline-Dependent Lentiviral Vector BILJANA GEORGIEVSKA,* JOHAN JAKOBSSON,* ELISABETH PERSSON, CEC

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_human_gene_therapy.pdf - 2026-05-29

REV_ISS_WEB_jnc_6650_113-4 836..847 *MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK Wallenberg Neuroscience Centre, Lund University, Lund, Sweden The midbrain dopaminergic (mDA) neurons are the largest assembly of dopaminergic neurons in the central nervous system and play an important role in motor control, reward, addiction and cognition (Bjorklund and Lindvall 1

https://www.regenerative-neurobiology.lu.se/sites/regenerative-neurobiology.lu.se/files/publication_in_j_neurochem.pdf - 2026-05-29

Introduction: Cytokine release syndrome (CRS) is a potentially severe systemic inflammatory condition triggered by various immunomodulatory therapies, making understanding its pathogenesis critical for improving patient outcomes. Results/Methods: By combining immunotoxicology and systems biology approaches, we offer a novel and integrative conceptual model of CRS as an adverse outcome (AO), induce

Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gu

Mantle cell lymphoma (MCL) is dependent on a supportive tumor immune microenvironment (TIME) in which infiltration of CD163+ macrophages has a negative prognostic impact. This study explores how abundance and spatial localization of CD163+ cells are associated with the biology of MCL, using spatial multiomic investigations of tumor and infiltrating CD163+ and CD3+ cells. A total of 63 proteins wer

WEAVE, the new wide-field, massively multiplexed spectroscopic survey facility for the William Herschel Telescope, saw first light in late 2022. WEAVE comprises a new 2-deg field-of-view prime-focus corrector system, a nearly 1000-multiplex fibre positioner, 20 individually deployable ‘mini’ integral field units (IFUs), and a single large IFU. These fibre systems feed a dual-beam spectrograph cove

BACKGROUND: ACURATE neo2 is a transcatheter aortic valve implantation system consisting of a self-expanding bioprosthetic valve with supra-annular leaflet position and featuring innovations to facilitate placement accuracy and reduce paravalvular regurgitation. METHODS AND RESULTS: The goal of the Early neo2 (Early neo2 Registry of the ACURATE neo2 TAVI Prosthesis) was to gather real-life data on

The biology centered around the TGF-beta type I receptor Activin Receptor-Like Kinase (ALK)1 (encoded by ACVRL1) has been almost exclusively based on its reported endothelial expression pattern since its first functional characterization more than two decades ago. Here, in efforts to better define the therapeutic context in which to use ALK1 inhibitors, we uncover a population of tumor-associated