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Recent studies have identified mutations in the complement regulatory gene factor I (CFI) that predispose to atypical hemolytic uremic syndrome (aHUS). CFI is a two-chain serine protease in which the light chain carries the catalytic domain while the heavy chain's function is unclear. It downregulates the alternative and classical complement pathways by cleaving the alpha' chains of C3b and C4b in
The Vel blood group antigen is carried on the short extracellular segment of the 78-amino-acid-long, type II transmembrane protein SMIM1 of unknown function. Here, using biochemical analysis and flow cytometry of cells expressing wild-type and mutant alleles of SMIM1, we demonstrate that dimerization of SMIM1 promotes cell surface display of the Vel epitope. We show that SMIM1 dimerization is medi
The optimal time interval from neoadjuvant therapy to surgery in the treatment of esophageal cancer is not known. The aim of this study was to investigate if a prolonged interval between completed neoadjuvant chemoradiotherapy and surgery was associated with improved histological response rates and survival in a population-based national register cohort. The population-based cohort study included
Popular Abstract in Swedish Antalet äldre i befolkningen ökar i förhållande till andra åldersgrupper. Detta beskrivs medföra en ekonomisk utmaning för samhället och att fler äldre behöver skjuta upp sin ålderspension. Avhandlingen bygger på fyra studier med det övergripande syftet att bidra till ökad kunskap om faktorer som medverkar till ett förlängt alternativt förkortat arbetsliv bland personerIn most of the industrialised world, the proportion of older and retired people in the population is continuously increasing. This will have budgetary implications for maintaining the welfare state, because the active working section of the population must fund the non-active and old population. Aim: The overall aim of this thesis was to obtain knowledge about older workers’ work and life situatio
We analyze the channel capacity of multiple-input multiple-output (MIMO) systems in frequcncy selective channels, with channel knowledge at the transmitter side. An optimum transmission scheme uses Shannon's principle of waterfilling jointly in the frequency and the spatial domain. However, we show in this paper that the largest gain by using waterfilling resides in the spatial domain, and that th
Popular Abstract in Swedish Avhandlingen behandlar det grekiska landskapet Argolis på östra Peloponnesos och vissa aspekter av livet där under drygt 600 år av romersk överhöghet. I området har man från den tiden funnit lämningar av städer, byar, villor och gårdar så väl som speciella anläggningar för framställning av olivolja, vin och keramik, dessutom badanläggningar, akvedukter, stenbrott, hamnaThis study focuses on the region of Argolid in the eastern part of the Greek Peloponnese during the Roman Imperial era, taking up a variety of aspects of life there based mainly on archaeological evidence. The introduction presents the study area and the background to the study. This is followed in the next chapter by a survey of the various kinds of sites of Roman date found in the Argolid. Citie
We have recently generated 5'lambda5-huTAC mice, which express the human CD25 (huTAC) gene under the control of the 5'-flanking region of the mouse lambda5-gene. The huTAC-transgene was expressed in pre-B cells but neither in mature B cells nor in T cells of these mice. In this report we demonstrate that the transgene is also transiently expressed by adult CD25+ CD3-CD4-CD8- (triple negative, TN)
Popular Abstract in Swedish Kvinnor mot krig. Aktioner och nätverk för fred 1914-1940. Syftet med avhandlingen är att undersöka varför och på vilket sätt kvinnor skapade fredsaktioner under första världskriget och mellankrigstiden. Jag har studerat hur kvinnor mobiliserades, hur aktionerna genomfördes, vilket motstånd som väcktes och vad som hände efteråt. Utgångspunkten är kollektiva aktioner, soThe aim of this dissertation is to investigate how and why women established peace actions during World War I and the period between the wars. I have examined how women were mobilized, how the actions were carried out, what kind of opposition was awakened, and what happened afterwards. My startingpoint is collective actions based on individual standpoints and temporary mobilizations. Organizations
Background: CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains are poorly understood. To better understand envelope glycoprotein (Env) determinants contributing to pathogenicity of R5 viruses, we characterized 37 full-length R5 Envs from cross
Coeliac disease and type 1 diabetes are autoimmune diseases that may share the same initiating environmental factors. In this study, the occurrence of type 1 diabetes associated autoantibodies (GADA and IA-2A) and tissue transglutaminase autoantibodies (TGA) was determined in patients with confirmed viral infections and no signs of type 1 diabetes or coeliac disease. Serum samples from 82 Cuban pa
Nontransient hypoxia is strongly associated with malignant lesions, resulting in aggressive behavior and resistance to treatment. We present an analysis of mRNA and protein expression changes in neuroblastoma cell lines occurring upon the transition from normoxia to hypoxia. The correlation between mRNA and protein level changes was poor, although some known hypoxia-driven genes and proteins corre
Popular Abstract in Swedish Hur ser det ut inuti protonen? Vi vet att protonen består av mindre partiklar. Den utgörs egentligen av tre st. kvarkar, men där finns också en mängd gluoner och virtuella kvarkar och antikvarkar. Gluonerna är de partiklar som håller ihop de tre kvarkarna (valenskvarkarna) i ett så hårt grepp att protonen blir väldigt liten (ca. 100000 ggr mindre än en atom). Det är deIn this thesis, we give a description of the detailed structure of the proton and a description of the final-state properties in electron-proton scattering. Qualitative results, in a purely gluonic scenario with the leading log approximation, and quantitative results, where quarks are included and some sub-leading corrections have been made, are presented. The quantitative results are in fair agre
Development of novel disease-modifying treatment strategies for neurological disorders, which at present have no cure, represents a major challenge for today's neurology. Translation of findings from animal models to humans represents an unresolved gap in most of the preclinical studies. Gene therapy is an evolving innovative approach that may prove useful for clinical applications. In animal mode
Staphylococcus aureus enterotoxin H (SEH) belongs to the staphylococcal enterotoxin (SE) family of superantigens (SAgs). SEH has structural similarities to other SE; however, its biological properties are less well characterized. SEH binds with high affinity to human major histocompatibility complex (MHC) class II and exhibits strong mitogenic activity in human T cells, although it was found to be
Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV prevalence in the general population. The present study describes the prevalence and spectrum of high-risk HPV types found in a large real-life population-based HPV screening trial undertaken entirely withi
Popular Abstract in Swedish Moraxella catarrhalis är en bakterie som tillhör vår normala bakterieflora. Den är dock också en luftvägspatogen som kan orsaka öroninflammation hos barn, nedre luftvägsinfektioner hos vuxna och äldre, och bihåleinflammation hos både barn och vuxna. Intresset kring M. catarrhalis som patogen har ökat de senaste 20 åren, både på grund av ökat antal insjuknande personer oMoraxella catarrhalis is a respiratory tract pathogen that causes significant health problems, including acute otitis media in children, lower respiratory tract infections in adults and the elderly and sinusitis in both children and adults. The interest in M. catarrhalis bacteria has increased over the past 20 years, both because of the emergence of the bacteria as a human pathogen and because of
Mucin-1 has proven to be a suitable target for antibody-based diagnosis and therapy of certain tumours, but no appropriate human antibody or antibody fragment displaying slow dissociation rate kinetics against this target is available. Since a rapid dissociation character prevents an antibody fragment from remaining at the site of the antigen, this fact may prevent the successful application of a
We fabricate a single billiard, a double billiard array, and a triple billiard array by etching a GaInAs/InP heterostructure, and perform a fractal analysis of the low-temperature magneto-conductance fluctuations measured in the billiards to facilitate an empirical study of how fractals combine in a physical system. We compare our results to simulated fractal traces, and find for both experiment a
Cosmological models predict the oldest stars in the Galaxy should be found closest to the centre of the potential well, in the bulge. The Extremely Metal-poor BuLge stars with AAOmega survey (EMBLA) successfully searched for these old, metal-poor stars by making use of the distinctive SkyMapper photometric filters to discover candidate metal-poor stars in the bulge. Their metal-poor nature was the
