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Introduction: Synovial fibroblasts (S-Fib) are recognized as key drivers of joint inflammation in adult arthritis. Moreover, data are limited on the processes driving monocyte activation in oligoarticular juvenile idiopathic arthritis (oJIA). Therefore, we aimed to explore if S-Fib from patients with oJIA induce monocyte activation. Methods: S-Fib were isolated from the synovial fluid (SF) of n =
BACKGROUND: Maternal status of long-chain PUFAs (LC-PUFAs) may be related to fetal growth. Maternal fish consumption exposes the mother to the neurotoxicant methylmercury (MeHg), which, in contrast, may restrict fetal growth. OBJECTIVE: Our aim was to examine relations between maternal LC-PUFA status at 28 wk and birth outcomes (birth weight, length, and head circumference), controlling for MeHg e
In order to better understand the relations between different risk factors in the predisposition to type 2 diabetes, we present a Bayesian Network analysis of a large dataset, composed of three European population studies. Our results show, together with a key role of metabolic syndrome and of glucose after 2 hours of an Oral Glucose Tolerance Test, the importance of education, measured as the num
Popular Abstract in Swedish Syftet med denna studie var att (I) utvärdera sambandet mellan övervikt mätt med det s.k. body mass index (BMI) och operation med höftleds- eller knäledsprotes (konstgjord led) på grund av artros, (II) utvärdera sambandet mellan mekanisk belastning på grund av yrke och operation med höftleds- eller knäledsprotes på grund av artros, (III) utvärdera naturalförloppet för eThe purpose of this study was to (I) assess the association between body mass index (BMI) and total hip replacement (THR) and total knee replacement (TKR) due to osteoarthritis (OA), (II) assess the association between the mechanical load of work and THR and TKR due to OA, (III) evaluate the natural history of radiographic hip OA with regards to THR and hip fracture, (IV) to determine the prevalen
This article aims to estimate the prevalence of SOX13 antibodies in Swedish patients with type 1 diabetes and healthy controls. The patients (n = 102; median age 35 years [range, 9-89]) were newly diagnosed with type 1 diabetes in a defined area in southern Sweden during 1995-1998. Islet cell antibodies (ICA) were analyzed with immunofluorescence, while glutamic acid decarboxylase antibodies (GADA
Popular Abstract in Swedish Detta arbete behandlar regleringen av arbetsgivarens arbetsledningsrätt och arbetstagarens arbetsskyldighet i svensk, engelsk och tysk rätt i ljuset av arbetslivets ökade flexibilisering. Arbetslivets flexibilisering handlar om att öka anpassningsförmågan och rörligheten, och beskrivs ofta som övergången från den traditionella anställningen till atypiska anställningar. The general aim of this doctoral thesis is to study the legal regulation of the managerial prerogative and how it relates to the employee’s obligation to work in Swedish, English and German law in the light of the increasing flexibilisation of working life. The ongoing flexibilisation of working life is often described as an increase in adaptability and allocative flexibility, and as a shift from
The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most
Cellular stress contributes to the capacity of melanoma cells to undergo phenotype switching into highly migratory and drug tolerant dedifferentiated states. Such dedifferentiated melanoma cell states are marked by loss of melanocyte specific gene expression and increase of mesenchymal markers. Two crucial transcription factors, MITF and SOX10, important in melanoma development and progression hav
IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a
HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in relation to viremia and markers of disease progression. The relationships between pathological diff
BACKGROUND: Antibody-based constructs for molecular imaging and therapeutic delivery provide promising opportunities for the diagnosis and treatment of atherosclerosis.OBJECTIVES: The authors aimed to generate and characterize immunoglobulin (Ig)G monoclonal autoantibodies in atherosclerosis for targeting of novel molecular determinants.METHODS: The authors created hybridomas from an unimmunized l
Background: Atherosclerotic plaque ruptures, triggered by blood flow–associated biomechanical forces, cause most myocardial infarctions and strokes. Objectives: This study aims to investigate the exact location and underlying mechanisms of atherosclerotic plaque ruptures, identifying therapeutic targets against cardiovascular events. Methods: Histology, electron microscopy, bulk and spatial RNA se
Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape of TNBC. By analyzing tumor methylome profiles and accounting for the genomic context of CpG methylation, we divide TNBC into two epigenetic subtypes corresponding to a Basal and a non-Basal group, in which characteristic transcrip
untitled LETTERS New flutes document the earliest musical tradition in southwestern Germany Nicholas J. Conard1, Maria Malina2 & Susanne C. Münzel3 Considerable debate surrounds claims for early evidence of music in the archaeological record1–5. Researchers universally accept the existence of complex musical instruments as an indication of fully modern behaviour and advanced symbolic communicatio
https://projekt.ht.lu.se/fileadmin/user_upload/sol/ovrigt/projekt_ccs/Conard_et_al._Flutes_Nature_2009.pdf - 2026-07-06
solen_16OKT2017_KORR3_JOBB.indd P O P U L Ä R V E T E N S K A P L I G T O M F O R S K N I N G I N O M M E D I C I N O C H H Ä L S A H Ö S T E N 2 0 1 7 på gott och ont Solen FÖDELSEM ÄRKET VITA MIN D DIN EGEN L JUSM ÄTARE Camilla drabbades mitt i livet Har du fått din dagliga dos av ljus? Ny app på gång Vad vet vi egentligen? Bränn dig inte! | Rymdväder | Så funkar solkrämer & Vetenskap & hälsa ge
https://www.vetenskaphalsa.se/wp-content/uploads/2017/10/Solen-p%C3%A5-gott-och-ont_webb.pdf - 2026-07-06
Kurskommentar Analytiska funktioner ht 2020 Anders Olofsson Resultatet p̊a kursen är 13 stycken G och 24 stycken VG fördelat p̊a tv̊a stycken tentamenstillfällen. Kursvärderingarna var genomg̊aende positiva, se r̊adata för detaljer. Genomförandet av kursen stördes av korona-utbrottet 2020. Pga r̊adande restrik- tioner ersattes salstentamen med examination i form av skriftlig hemtentamen. Pg
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/HT2020/MATM12HT2020KA.pdf - 2026-07-06
Centre for Mathemat ica l Sc iences Divis ion of Mathemat ics and Numerica l Analys is Course Analysis for MATB22 Linear Algebra 2, Spring 2024 Course Information Lecturer: Anitha Thillaisundaram Teaching assistants: Jan Henrik Thomm and Thomas Munn Number of students: 44 newly registered and 21 re-registered. 14 students answered the course evaluation, all of them are enrolled on programme name.
https://www.maths.lu.se/fileadmin/maths/Matematik_NF/Kursutvaerderingar/VT2024/MATB22VT24.pdf - 2026-07-06
VI International Conference on Computational Methods for Coupled Problems in Science and Engineering COUPLED PROBLEMS 2015 B. Schrefler, E. Oñate and M. Papadrakakis(Eds) CONVERGENCE SPEED OF COUPLING ITERATIONS FOR THE UNSTEADY TRANSMISSION PROBLEM AZAHAR MONGE∗ AND PHILIPP BIRKEN∗ ∗Centre for Mathematical Sciences Lund University Box 118, 22100, Lund, Sweden e-mail: azahar.monge@na.lu.se, web p
https://www.maths.lu.se/fileadmin/maths/personal_staff/Philipp_Birken/coupled.pdf - 2026-07-07
