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An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal mass spectrometry-based strategy for in-depth characterization of antigen–antibody complexes to enable the identification of protective epitopes using the cytolytic exotoxin
This paper reframes our understanding of the discourse on work-life balance (WLB) from a global perspective, where life on the four income levels (from bottom of the wealth to top of the wealth) is equally considered. Based on a systematic literature review, our initial insights are that WLB of workers in the highest economic sectors has received significant attention from scholars and practitione
Background: A growing literature suggests associations between occupational pesticide exposure and respiratory health. In this study, we aimed to examine the association of exposure to insecticides, fungicides, and herbicides, individually and as a mixture, with respiratory health outcomes and rhinitis in avocado farmworkers from Michoacán, Mexico. Material and methods: We conducted a cross-sectio
PURPOSE: Autoantibodies to thyroid peroxidase (TPOAb) and thyroglobulin (TgAb) define pre-clinical autoimmune thyroid disease (AITD) which can progress to either clinical hypo- or hyperthyroidism. We determined the age at seroconversion in children genetically at risk for type 1 diabetes.METHODS: TPOAb and TgAb seropositivity were determined in 5066 healthy children with HLA DR3 or DR4 containing
BACKGROUND: By causing inflammation and tissue damage, neutrophil extracellular traps (NETs) constitute an underlying mechanism of aspiration-induced lung injury, a major factor of the low utilization of donor lungs in lung transplantation (LTx).METHOD: To determine whether NET removal during ex vivo lung perfusion (EVLP) can restore lung function and morphology in aspiration-damaged lungs, gastri
BACKGROUND: Excessive dietary salt intake is associated with elevated blood pressure and damage to organs including the heart, vasculature, and kidneys. Women are more prone to salt-sensitive hypertension, yet preclinical studies often focus on men.METHODS: To examine sex-specific responses to chronic salt loading, male and female C57Bl6/J mice were fed a high-salt diet (HSD; 8% NaCl) from 7 to 14
OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams
22 Ahadi_Melin_Reistad_2012 LTHs 7:e Pedagogiska Inspirationskonferens, 30 augusti 2012 Sammanfattning — Grundkursen i Mekanik för Industriell Ekonomi innehåller statik och dynamik och läses under en läsperiod, Lp 3, under utbildningens första år. Antalet studenter är ca 110. Kursens omfattning är 9 hp vilket motsvarar ca 240 timmars studier fördelade på 7 veckor. Undervisningen består av föreläsn
https://www.lth.se/fileadmin/lth/genombrottet/konferens2012/11_Ahadi_etal.pdf - 2026-06-09
Check list for employees 2022-10-13 Checklist for New Employees and Visiting Scholars Room: ___________________________ Telephone: ___________________________ Email: ___________________________ Departmental mailing lists: personal@fil.lu.se (only personnel and visiting scholars) personal@lucs.lu.se (cognitive science group) The newsletter of the Faculty of Humanities and Theology “HT-bulletin” and
https://www.fil.lu.se/fileadmin/user_upload/fil/dokument/pdf/Check_list_for_employees_221013.pdf - 2026-07-04
1 Nordisk kost | Alzheimermedicin | Barns ätproblem p o p u l ä r v e t e n s k a p l i g t o m f o r s k n i n g i n o m m e d i c i n o c h h ä l s a V Å R E N 2 0 2 2 & NÄR DET GÅR ÖVER HON GLÖMDE FLER A ÅR ANTI INFL A MM ATORISK KOST? Sunda matmönster bättre Fick identitetskris när minnet skadades Minnet kan svikta vid infektion och hälsan Minnet, maten Vetenskap & hälsa ges ut av Medicinska f
https://www.vetenskaphalsa.se/wp-content/uploads/2022/05/Minnet-maten-och-halsan-2022.pdf - 2026-07-04
LTH-nytt Om bilar kunde tala Robot ska ge fyra armar Sensorer för minskat matsvinn LTH | LUNDS TEKNISKA HÖGSKOLA | MAGASIN | NR 1 2019 Digitalisering – till nytta för oss människor I detta nummer TILL NYTTA FÖR | DIGITALISERING .................................... 4 Omvälvning med rika möjligheter ..................................... 4 Krönika: Till nytta för oss .................................
https://www.lth.se/fileadmin/lth/omlth/kommunikation/lthnytt/LTH-nytt_1_2019_web.pdf - 2026-07-04
Galectin-3 (Gal-3), an endogenous lectin, exhibits ro- and anti-inflammatory effects in various disease conditions. In order to explore the role of Gal-3 in KT-cell-dependent pathology, we induced hepatitis in C57BL/6WT and al-3-deficient mice by using specific ligand for KT cells: alpha-galactosylceramide, glycolipid Ag presented by CD1d. The injection of alpha-galactosylceramide significantly en
In this study, we describe the expression and function of CD40, a TNF receptor family member, in cervical carcinomas. CD40 was present at very low levels in normal cervical epithelium but was overexpressed in human papillomavirus-infected lesions and advanced squamous carcinomas of the cervix. The stimulation of CD40-positive cervical carcinoma cell lines with soluble CD40L (CD154) resulted in act
Popular Abstract in Swedish Bibeln, och framför allt Nya Testamentet, har präglat det västerländska tänkandet i en utsträckning som inte alltid noteras i nyare historieskrivning. En ledande roll har spelats av de uppfattningar av Gud som förmedlas av de fyra evangelierna. Inte minst har läsningar av Johannesevangeliet genomsyrat de kristna tänkarnas försök att formulera synen på Guds väsen, egenskThis book presents an exhaustive and systematic investigation of six representatives of three important periods of New Testament interpretation: Martin Luther, John Calvin, Brooke Foss Westcott, Heinrich Julius Holtzmann, Rudolf Bultmann and Raymond E. Brown. They serve as dialogue partners in an investigation of the notion of God in the Fourth Gospel, a topic that has been called “the neglected f
The ion photon emission microscope, or IPEM, is the first device that allows scientists to microscopically study the effects of single ions in air on semiconductors, microchips and even biological cells without having to focus the beam. Reported here is a prototype, the size of a conventional optical microscope, developed at Sandia. The alpha-IPEM, that employs alpha particles from a radioactive s
Hematologic malignancies are characterized by fusion genes of biological/clinical importance. Immortalized cell lines with such aberrations are today widely used to model different aspects of leukemogenesis. Using cDNA microarrays, we determined the gene expression profiles of 40 cell lines as well as of primary leukemias harboring 11q23/MLL rearrangements, t(1;19)[TCF3/PBX1], t(12;21)[ETV6/RUNX1]
This study, which is the first and main part of a two-volume work, is concerned with the history and philology of original and translated works Adversus Iudaeos circulating among the Eastern Slavs from the baptism of Rus' c.988 till the early 16th century. Excluded is the literature of Lithuanian Ruthenia from the 14th century onwards. On the material of 11–15th-century MSS the dissemination of th
The MYC genes are the most frequently activated oncogenes in human tumors and are hence attractive therapeutic targets. MYCN amplification leads to poor clinical outcome in childhood neuroblastoma, yet strategies to modulate the function of MYCN do not exist. Here we show that 10058-F4, a characterized c-MYC/Max inhibitor, also targets the MYCN/Max interaction, leading to cell cycle arrest, apopto
Cyclooxygenase-2 (COX-2) is an inducible enzyme that drives inflammation and is the therapeutic target for widely used nonsteroidal antiinflammatory drugs (NSAIDs). However, COX-2 is also constitutively expressed, in the absence of overt inflammation, with a specific tissue distribution that includes the kidney, gastrointestinal tract, brain, and thymus. Constitutive COX-2 expression is therapeuti
The type I interferon system genes IKBKE and IFIH1 are associated with the risk of systemic lupus erythematosus (SLE). To identify the sequence variants that are able to account for the disease association, we resequenced the genes IKBKE and IFIH1. Eighty-six single-nucleotide variants (SNVs) with potentially functional effect or differences in allele frequencies between patients and controls dete
