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Popular Abstract in Swedish Ämnet för denna tematiska och berättartekniska studie i litteraturvetenskap är C. J. L. Almqvists slottskrönika och det indirekta skrivsättet. Slottskrönikan omfattar romanerna Jaktslottet (1833), Hinden (1833) och Baron Julius K*. Ur Fröken Eleonoras Reseminnen (1835), vilka belyses med hjälp av Almqvists uppsats Om två slags Skrifsätt (1833). Denna infogades senare i The subject of this thematic and narrative-technical study is the Swedish author Carl Jonas Love Almqvist's (1793-1866) slottskrönika (castle chronicle) and the indirect way of writing. The castle chronicle comprises the novels Jaktslottet (The Hunting Castle; 1833), Hinden (The Hind; 1833) and Baron Julius K* (1835), all of which are included in Almqvist's great collective work, Törnrosens bok (T

The work presented in this thesis has been focused on mesenchymal stem cells (MSCs). In the two first studies, the effects of MSCs on tumor growth and development in vitro and in vivo was investigated. In the third study the expression of the integrins alpha10beta1 and alpha11beta1 on MSCs was characterized and the involvement of these two integrins in cartilage development was investigated in vit

AbstractHuman papillomaviruses (HPVs) are small non enveloped viruses that contain a double-stranded circular DNA genome of approximately 8kb in size. It has been estimated that approximately 5% of all cancers are caused by HPV infection. Cervical cancer represents the majority of HPV-associated anogenital cancers worldwide. HPV type16 (HPV16) accounts for 65% of cervical cancer and approximately

Adopting circular business models (CBM) represents a key lever for industry to address urgent global challenges. Prior research recognizes the need for systems thinking and collaboration, but existing CBM tools and methods often implicitly assume that the focal firm has direct access to end customers, usage data and end-of-life phases. However, upstream suppliers who lack this access often produce

Helminth/tuberculosis (TB)-coinfection can reduce cell-mediated immunity against Mycobacterium tuberculosis (Mtb) and increase disease severity, although the effects are highly helminth species dependent. Mtb have long been ranked as the number one single infectious agent claiming the most lives. The only licensed vaccine for TB (BCG) offers highly variable protection against TB, and almost no pro

BACKGROUND: Galectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclonal antibody pembrolizumab. We aimed to assess if the effect of Gal-3 was a result of direct interaction with the immune checkpoint receptor.METHODS:

In the absence of early B-cell factor 1 (EBF1), B-cell development is arrested at an uncommitted progenitor stage that exhibits increased lineage potentials. Previously, we investigated the roles of EBF1 and its DNA-binding partner Runx1 by evaluating B lymphopoiesis in single (EBF1(het) and Runx1(het)) and compound haploinsufficent (Ebf1(+/-) Runx1(+/-), ERhet) mice. Here, we demonstrate that dec

The identification of intestinal macrophages (mφs) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial. We show here that intestinal CD103(-)CD11b(+) MPs can be separated clearly into DCs and mφs based on phenotype, gene profile, and kinetics. CD64(-)CD103(-)CD1

Drought has negative impacts on water resources, food security, soil degradation, desertification and agricultural productivity. The meteorological and hydrological droughts prediction using standardized precipitation/runoff indices (SPI/SRI) is crucial for effective water resource management. In this study, we suggest ANFISWCA, an adaptive neuro-fuzzy inference system (ANFIS) optimized by the wat

Background: The complement system seems to influence cancer pathophysiology. The primary aim of this study was to explore complement components associated with the classical pathway (CP) of the complement system in peripheral blood from patients with IDH–wild-type (IDH-wt) glioblastoma. Methods: Patients undergoing primary surgery due to glioblastoma in the years 2019–2021 were prospectively inclu

Environmental exposure to noise and particle matter (PM) are risk factors for cardiovascular disease (CVD). Although there are often higher levels in occupational settings, little is known about noise and particle exposures at work and CVD risks. We investigated occupational noise and particle exposures and acute effects on pulse rate and blood pressure. 46 active, non-smoking, male construction w

We discovered nocturnal colour vision in the Asian giant honeybee Apis dorsata - a facultatively nocturnal species - at mesopic light intensities, down to half-moon light levels (approx. 10 -2 cd m -2). The visual threshold of nocturnality aligns with their reported nocturnal activity down to the same light levels. Nocturnal colour vision in A. dorsata is interesting because, despite being primari

HIP 9618 (HD 12572, TOI-1471, TIC 306263608) is a bright (G = 9.0 mag) solar analogue. TESS photometry revealed the star to have two candidate planets with radii of 3.9 ± 0.044 R (HIP 9618 b) and 3.343 ± 0.039 R (HIP 9618 c). While the 20.77291 d period of HIP 9618 b was measured unambiguously, HIP 9618 c showed only two transits separated by a 680-d gap in the time series, leaving many possibilit

Background: Antibody-mediated complement fixation has previously been associated with protection against malaria in naturally acquired immunity. However, the process of early-life development of complement-fixing antibodies in infants, both in comparison to their respective mothers and to other immune parameters, remains less clear. Results: We measured complement-fixing antibodies in newborns and

Collisionless dark matter only (DMO) structure formation simulations predict that dark matter (DM) haloes are prolate in their centres and triaxial towards their outskirts. The addition of gas condensation transforms the central DM shape to be rounder and more oblate. It is not clear, however, whether such shape transformations occur in 'ultra-faint' dwarfs, which have extremely low baryon fractio

The intestinal lamina propria (LP) contains distinct subsets of classical dendritic cells (cDC), each playing key non-redundant roles in intestinal immune homeostasis. Here, we show that glycoprotein 2 (GP2), a GPI-anchored protein and receptor for bacterial type-I fimbriae, is selectively expressed by CD103+CD11b+ cDC in the murine small intestine (SI). GP2 expression was induced on CD103+CD11b+