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Parkinson's disease (PD) is a neurodegenerative disease with unknown etiology. Here we show the generation of an induced pluripotent stem cell (iPSC) line, named CSC-40, from dermal fibroblasts obtained from a 59-year-old male patient with a homozygous p.Q456X mutation in the PTEN-induced putative kinase 1 (PINK/PARK6) gene and a confirmed diagnosis of PD, which could be used to model familial PD.

In aqueous solution of 1,1'-diethyl-2,2'-carbocyanine J-aggregate, the exciton self-trapped (EST) state is usually expected to be negligible. However, in this work, by measuring transient absorption spectroscopy under a variety of excitation fluences, the EST state was found to be formed via coherent exciton-exciton annihilation (EEA), when the excitation fluence was high enough. With the existenc

Lamb modes with zero group velocity at nonzero wave numbers correspond to local and stationary resonances in isotropic plates. Lamb modes can be utilized for nondestructive evaluation of the elastic properties and thickness. One example of an application is the testing of plate-like concrete structures. In this example, continuous variation in the material velocity through the thickness may occur.

Mouse embryonic stem cell (mESC) lines were derived by crossing heterozygous transgenic (tg) mice expressing green fluorescent protein (GFP) under the control of the rat tyrosine hydroxylase (TH) promoter, with homozygous alpha-synuclein (aSYN) mice expressing human mutant SNCAA53T under the control of the mouse Prion promoter (MoPrP), or wildtype (WT) mice. The expression of GFP and human aSYN wa

Under 2012–2014 organiserade VIWAFU, ett nätverk för internationellt och interdisciplinärt forskarsamarbete i Norden och Baltikum, fyra seminarier för master-studenter, doktorander och post-docs. Var och ett av seminarierna hade ett tema, t.ex. VA-branschens reglering och styrning, infrastruktur för dricksvatten, innovativ utveckling inom kommunala vattenfrågor samt vattenhantering Viable Water Management and Governance for Futures (VIWAFU), a professional network for international and interdisciplinary collaboration amongst researchers from the Nordic and Baltic countries, was built for providing and sharing knowledge on water management and governance for future policy and decision making during the years 2012–2014. VIWAFU organized four workshops for MSc stud

Lessons of history are two-sided cultural products. They serve as active instruments of temporal orientation in a society in which historical trajectories seem obsolete and the future open, but they are also passively framed within historical cultures that often have prefigured them. Thus, lessons are seldom arbitrarily constructed. while lessons of history for many centuries

This collection seeks to illustrate the state of the art in territoriological research, both empirical and theoretical. The volume gathers together a series of original, previously unpublished essays exploring the newly emerging territorial formations in culture, politics and society.While the globalisation debate of the 1990s largely pivoted around a ‘general deterritorialisation’ hypothesis, sin

The aim of these experiments was to obtain a detailed knowledge of how the orbicularis oculi muscle is activated during the execution of a conditioned eyeblink response (CR). This is the first critical step to understand the underlying neural mechanisms involved in the control of the CR. Decerebrate ferrets were trained in a classical conditioning paradigm. The conditioned stimulus (CS) was a trai

This introduction presents an overview of the key concepts discussed in the subsequent chapters of this book. The book focuses on a collective of international scholars who are researching at the intersections of media, mobility and sociality. It explores the divergent vantage points of the interplay between mobilities and socialities, analysing material conditions, situated contexts and the ascri