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Popular Abstract in Swedish Målsättningen i denna avhandling är att identifiera funktionen hos COMP (Cartilage Oligomeric Matrix Protein). Detta protein finns framförallt i brosk och sena. Dessa vävnader tillhör bindväven och har till funktion att ta upp och fördela belastning, utgöra ett skydd och förmedla transport av olika ämnen. De är uppbyggda av ett fåtal celler inbäddade i en dominerande exConnective tissues contain a prominent extracellular matrix that provides mechanical and physical properties. This extracellular matrix contains as a major constituent a network of collagen fibres. These are composed of collagen fibrils, which in turn are assembled from many collagen molecules aligned parallel to each other. Several proteins, e.g. collagens, leucine-rich repeat proteins and thromb

BACKGROUND: Recent studies have suggested that reactive oxygen species may be involved in the development of diabetic retinopathy. METHODS: Nitro blue tetrazolium (NBT) staining, a marker of reductants which may be induced by free radicals such as superoxide, and catalase activity, as an indirect measure of hydrogen peroxide (H2O2) generation, were studied in the rat retina in three conditions kno

The pathogenesis of Parkinson’s disease (PD) involves the accumulation of aggregated -synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we determined the capacity of the appendix to modify PD risk and influence pathogenesis. In two independent epidemiological datasets, involving more than 1.6 million individuals and over 91 million person-years, we observed that rem

Populärvetenskaplig sammanfattning/Populärwissenschaftliche Zusammenfassung (först på svenska/Schwedisch och därefter på tyska/Deutsch)Nästan alla metalliska material som används idag är legeringar. Detta beror på att legeringen har förbättrade fysiska egenskaper som hållfasthet, slitstyrka och korrosionsbeständighet och dessutom bättre prestanda vid höga temperaturer jämfört med de enskilda rena This thesis reports on surface studies of industrial materials whose importance for society manifests in the vast range of applications. In industrial materials alloying is performed in order to improve the parent material's physical and mechanical properties such as strength, corrosion and wear resistance, as well as high temperature performance in comparison to the pure metal.Even though metals

In the 1870s, William Smith Clark was a successful botanist and president of Massachusetts Agricultural College. Nevertheless, frustrated by university politics, financial difficulties, and perhaps a midlife crisis, Clark was recruited by the Japanese government to establish an agricultural college on the northeast Asian island of Hokkaido, where Japan had recently begun an ambitious settler colon

Postoperative morbidity after hysterectomy was studied prospectively in 229 consecutive patients in our departments. The incidence of alcohol abuse (> or = 60 gm of alcohol daily) and moderate drinking (between 25 and 60 gm of alcohol daily) was 6.5% for each. When compared with the moderate drinkers and the control group, the alcohol abusers developed significantly more complications (80% versus

BACKGROUND: To investigate the correlation between various orthopedic conditions and overweight/obesity at the Department of Orthopedics, Malmö University Hospital Sweden. Obesity is associated with numerous major medical conditions. Although the relationship between gonarthrosis and osteoarthritis and body mass index (BMI) is well recognized, other orthopedic conditions have been less well studie

Many critics have noted Ah Cheng’s extensive use of Daoist imagery and symbolism in his novella King of Chess from 1984. The story refers directly to Daoist discourse of non-action (无为wuwei) and the power of yielding/softness in its treatment of the Chinese Way (道dao) of chess, and thus readings have focused on the metaphysical aspects of Daoism. Chess, howeve