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At advanced stages of Alzheimer's disease, cognitive dysfunction is accompanied by severe alterations of hippocampal circuits that may largely underlie memory impairments. However, it is likely that anatomical remodeling in the hippocampus may start long before any cognitive alteration is detected. Using the well-described Tg2576 mouse model of Alzheimer's disease that develops progressive age-dep
The enzyme myeloperoxidase shows several unusual properties compared to other peroxidases, e.g. a red-shifted absorption spectrum and a peroxidase activity towards chloride. It has been suggested that this is caused by the unusual covalent links between the heme group and the surrounding protein, but whether it is caused by the two ester links to Glu-242 and Asp-94 or the sulfonium ion linkage to
Quantitative genetic parameters are nowadays more frequently estimated with restricted maximum likelihood using the 'animal model' than with traditional methods such as parent-offspring regressions. These methods have however rarely been evaluated using equivalent data sets. We compare heritabilities and genetic correlations from animal model and parent-offspring analyses, respectively, using data
Background: Poor mental health is a major issue worldwide and causality is complex. For diseases with multifactorial background synergistic effects of person-and place-factors can potentially be preventive. Nature is suggested as one such positive place-factor. In this cohort study we tested the effect of defined green qualities (Serene, Space, Wild, Culture, Lush) in the environment at baseline o
The jet energy scale (JES) and its systematic uncertainty are determined for jetsmeasured with the ATLAS detector using proton-proton collision data with a centre-of-mass energy of root s = 7 TeV corresponding to an integrated luminosity of 4.7 fb(-1). Jets are reconstructed from energy deposits forming topological clusters of calorimeter cells using the anti-kt algorithmwith distance parameters R
This dissertation is the first academic treatment and systematic analysis on the theology of Bishop Ding Guangxun (K.H. Ding) who is an internationally- renowned Christian leader of the Chinese Protestant Church in contemporary China. It seeks to explore the development of Bishop Ding’s contextual theology with special emphasis on his political theology of accommodation and cultural indigenization
Background: The link between squamous cell cervical carcinoma and human papillomavirus (HPV) 16/18 is well established, but the magnitude of the risk association is uncertain and the importance of other high-risk HPV (HRHPV) types is unclear. Methods: In two prospective nested case-control series among women participating in cytologic screening in Sweden, we collected 2,772 cervical smears from 51
Daylight plays a major role in making atrium spaces appealing to building users. This appeal is also evident in the spaces adjoining the atrium. A key component of atrium daylighting, especially in tall atria, is the daylight reflected on to the atrium walls. This study examines the impacts of well geometries and different diffuse reflectance distributions of walls on variations of vertical intern
The phenomenon of water vapour sorption by anhydrous C(3)A polymorphs both in the absence and in the presence of CaSO4 center dot 0.5 H2O was studied utilising dynamic and static sorption methods. It was found that orthorhombic C(3)A starts to sorb water at 55% relative humidity (RH) and cubic C(3)A at 80% RH. Also, C(3)Ao sorbs a higher amount of water which is predominantly physically bound, whe
We use a recently developed parametrization to estimate the regional particle field in the summer time troposphere over Scandinavia that would result if the forest were the only source of particles. The calculated field is compared with available observational data. It is concluded that the needle leaf forest above 58 degrees N alone is capable of producing aerosol mass concentrations correspondin
In autobiographical writing, the mirror is not only a privileged metaphor for the genre as a whole; it also functions as a primary administrator of boundaries, demarcating the space of the self from the foreign, the chaotic, the unknown. The mirror metaphor is not a gender neutral one: in Western elite culture the mirror has served to reinforce the patriarchal dichotomy between man/mind and woman/
The vibrational properties of the CO/Cu(100) surface adsorbate system have been explored by infrared spectroscopy and DFT cluster calculations. We show that all four fundamental, FT(x,y), FR(x,y), FT(z) and ν(C-O), vibrational modes are very well reproduced with respect to experiments by the present calculations and they are at the highest level reported to date. Our work demonstrates that it is e
Background: Patients living under better socioeconomic circumstances often receive more active treatments after an acute myocardial infarction ( AMI) compared to less affluent patients. However, most previous studies were performed in countries with less comprehensive coverage for medical services. In this Swedish nation- wide longitudinal study we wanted to evaluate long- term survival after AMI
To estimate the effects of smoking, gender and occupational exposure on the risk of developing severe pulmonary fibrosis (PF), including dose-response and interaction effects.
Bismuth (Bi) induced c(4 x 4) surface structure of the GaAs(1 0 0) substrate, i.e., the GaAs(1 0 0)c(4 x 4)-Bi surface has been studied with synchrotron-radiation photoelectron spectroscopy and ab initio calculations. The surface was prepared by combining molecular beam epitaxy and in situ electron diffraction methods, and then the sample was transferred to a photoemission chamber without breaking
Systemic lupus erythematosus (SLE) is an autoimmune rheumatic disorder characterized by inflammation in several organ systems. SLE patients have an impaired ability to clear dying cells which leads to the exposure of several nuclear antigens which might break self tolerance. Autoantibodies directed against the nuclear antigens will form large immune complexes (ICs) which are central in the immunop
The inclusive production of D*(+/-)(2010) mesons in deep-inelastic e(+/-)p scattering is measured in the kinematic region of photon virtuality 100 < Q(2) < 1000 GeV2 and inelasticity 002 < y < 0 7 Single and double differential cross sections for inclusive D* meson production are measured in the visible range defined by vertical bar eta(D*)vertical bar < 1 5 and p(gamma)(D*) > 1 5 GeV The data wer
