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The 10th consecutive World Health Economics conference was organized jointly by International Health Economics Association and European Conference on Health Economics Association and took place at The Trinity College, Dublin, Ireland in July 2014. It has attracted broad participation from the global professional community devoted to health economics teaching,research and policy applications. It ha
Many sea urchins can detect light on their body surface and some species are reported to possess image-resolving vision. Here, we measure the spatial resolution of vision in the long-spined sea urchin Diadema africanum, using two different visual responses: a taxis towards dark objects and an alarm response of spine-pointing towards looming stimuli. For the taxis response we used visual stimuli, w
In the transportation literature, equity has been and is still used with a variety of meanings and purposes. Traditionally, equity has been considered in strategic transport planning but very few works have been addressing it in a quantitative way, detailing how to explicitly consider it at a transportation design level (tactical and/or operational) focusing on the consequent social role of transp
Two-particle pseudorapidity correlations are measured in sNN=2.76TeVPb+Pb, sNN=5.02TeVp+Pb, and s=13TeVpp collisions at the Large Hadron Collider (LHC), with total integrated luminosities of approximately 7μb-1, 28 nb-1, and 65 nb-1, respectively. The correlation function CN(η1,η2) is measured as a function of event multiplicity using charged particles in the pseudorapidity range |η|<2.4. The corr
The interaction between microorganisms that contain thick cell walls, such as the Gram-positive bacterium Enterococcus faecalis, and conductive surfaces can be improved by using redox polymers as mediators. Herein, we report a detailed electrochemical characterization of the communication between E. faecalis cells and a series of osmium redox polymers with different redox potentials. The current g
Benthic macroinvertebrates are part of a complex network of interactions. The spatial and temporal scales of the processes that form the basis for these interactions have traditionally restricted their empirical investigation. The first chapter of the manuscript attempts a review of the modelling tools that have been employed for the study of the marine benthos.The implementation of a mechanistic
An experimental campaign has been carried out with the aim of providing an insight into the fracture processes occurring during the cutting of different types of polymers, with features ranging from typically brittle to soft hyperelastic behaviour. The steady state of cutting is investigated using a sharp thin blade, and tracking the insertion force versus the penetration displacement. For soft, h
Background: Cell therapy constitutes an attractive alternative to treat stress urinary incontinence. Although promising results have been demonstrated in this field, the procedure requires further optimization. The most commonly proposed cell types for intraurethral injections are muscle derived cells (MDCs) and mesenchymal stem/stromal cell (MSCs). The aim of this study was to evaluate the effect
The intestinal dietary fibre degradation and faecal bulking capacity of various bulk laxatives were investigated by means of balance experiments on rats. Nitrogen, fat, and mineral excretion in faeces was also studied. The dietary fibre content of the various bulk laxatives was quite different (in g/kg dry matter): ACO fibre tablets (barley and citrus pulp), 451; Fiberform (wheat bran-based), 817;
We have estimated free energies for the binding of eight carboxylate ligands to two variants of the octa-acid deep-cavity host in the SAMPL6 blind-test challenge (with or without endo methyl groups on the four upper-rim benzoate groups, OAM and OAH, respectively). We employed free-energy perturbation (FEP) for relative binding energies at the molecular mechanics (MM) and the combined quantum mecha
The acute respiratory distress syndrome (ARDS) is a serious and common complication of multiple medical and surgical interventions, with sepsis, pneumonia, and aspiration of gastric contents being common risk factors. ARDS develops within 1 week of a known clinical insult or presents with new/worsening respiratory symptoms if the clinical insult is unknown. Approximately 40% of the ARDS cases have
Understanding and managing the responses of natural systems to climate change requires knowing whether recent changes in ecosystem structure and function are within the bounds of natural variation or whether the systems are entering new states that are unprecedented. Several recent studies of the fossil diatom record of the last ~ 150 years in Andean lakes have shown changes in diatom species comp
Background: Geographic cancer health disparities have been reported in Sweden. The disparities are not fully understood, but may be attributed to differences in exposure to risk factors as well as differences in health care, socioeconomics and demography. The aim of this study was to describe the new nationwide population based RISK North database and its potential by analysing health disparities
The digestibility of starch in white wheat bread was studied. Raw wheat starch and raw wheat flour were used as reference materials. The extent of digestion and absorption in vivo was evaluated through balance experiments in rats given test diets with and without addition of the antibiotic, Nebacitin, to reduce the fermentation in the hind-gut. As judged from a high faecal recovery of dietary fibr
Introduction: Cardiac syncope heralds significantly higher mortality compared with syncope due to noncardiac causes or unknown etiology, commonly considered a benign event. A few epidemiologic studies have examined the outcome of noncardiac/unexplained syncope comparing individuals with and without syncope, but with controversial results. We performed a systematic review and meta-analysis to clari
Previous studies have reported that chromosome synteny in Lepidoptera has been well conserved, yet the number of haploid chromosomes varies widely from 5 to 223. Here we report the genome (393 Mb) of the Glanville fritillary butterfly (Melitaea cinxia; Nymphalidae), a widely recognized model species in metapopulation biology and eco-evolutionary research, which has the putative ancestral karyotype
Non-coding RNAs regulate many biological processes including neurogenesis. The brain-enriched miR-124 has been assigned as a key player of neuronal differentiation via its complex but little understood regulation of thousands of annotated targets. To systematically chart its regulatory functions, we used CRISPR/Cas9 gene editing to disrupt all six miR-124 alleles in human induced pluripotent stem
OBJECTIVES: Few longitudinal studies have studied the association between body mass index (BMI) and hand osteoarthritis (OA). We aimed to explore the association between BMI and progressive hand OA in a longitudinal study of the Oslo hand OA cohort.METHOD: Participants with existing hand OA had hand radiographs and BMI data taken at baseline and 7-year follow-up (n = 103). The radiographs were rea
Local governments’ limited mandate and capacity to adequately deal with increasing climate risk and impacts means that citizen engagement is becoming increasingly important for adapting to hazards such as floods and storms. Stronger collaborative approaches are urgently needed. At the same time, there is little research and hardly any empirical evidence on what inspires adaptation engagement in di
