Filetype
In this lecture, we will discuss the emergence of the semiotic function, both ontogenetically and phylogenetically, and we will consider the part played by the picture sign in this development. In order to demonstrate that pictures are indeed signs, we will explore the basic elements of the sign presupposed but never put into focus neither by Saussure nor by Peirce. Indeed, explorations in the psy
Daniel Hjorth and Chris Steyaert make a unique contribution to management education. Their ability to illustrate complex ideas through theatre and visual media is outstanding and much appreciated by a wide audience. This book is no exception. Their insights into the nature of entrepreneurship are fresh and original. Their style of presentation is both rich and rewarding. This is a book to surprise
1. Two recent clinical trials, KetECT and ELEKT-D, compared the effectiveness of ketamine and electroconvulsive therapy (ECT) for major depressive disorder. Notably, these trials reported marked differences in ECT's clinical outcomes of, with remission rates of 63% for KetECT and a strikingly lower rate of 22% for ELEKT-D, while the remission rates for ketamine were 46% and 38%, respectively. Cons
The scaling relations between the gas content and star formation rate of galaxies provide useful insights into the processes governing their formation and evolution. We investigated the emergence and the physical drivers of the global Kennicutt-Schmidt (KS) relation at 0:25 ≤ z ≤ 4 in the cosmological hydrodynamic simulation NewHorizon, capturing the evolution of a few hundred galaxies with a reso
In the context of the current refugee crisis, there has been a revival of concern with territoriality, nationality, and identity throughout Europe. In response to this revival, Reiner Anselm develops a theological ethics of community and citizenship from a Protestant perspective. Concentrating on the controversies which have characterized German Protestantism, he analyzes how theologians have aime
The conserved pre-mRNA retention and splicing (RES) complex, which in yeast consists of Bud13p, Snu17p and Pml1p, is thought to promote nuclear retention of unspliced pre-mRNAs and enhance splicing of a subset of transcripts. Here, we find that the absence of Bud13p or Snu17p causes greatly reduced levels of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA and that a lack of Pml1p redu
Large language models (LLMs) like GPT-4 have the potential to dramatically change the landscape of influence operations. They can generate persuasive, tailored content at scale, making campaigns using falsified content, such as disinformation and fake accounts, easier to produce. Advances in self-hosted open-source models have meant that adversaries can evade content moderation and security checks
Students’ beliefs about division by zero and numbers on the number line werestudied through explanations of the concepts in questionnaires and interviewsduring their teacher education to become primary school teachers in the years4–6. The concepts were chosen for students’ proven cognitive challenges incoping with them, with the aim to add to the existing knowledge in terms ofspecific and general
Little is known on the spreading capacities of Limnomonas gaiensis across freshwater lakes in Northern Europe. In this study, we show that the species could successfully be aerosolized from water sources by bubble bursting (2-40 particles.cm−3), irrespectively of its density in the water source or of the jet velocity used to simulate wave breaking. The species viability was impacted by both water
Background: Predicting future Alzheimer’s disease (AD)-related cognitive decline among individuals with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) is an important task for healthcare. Structural brain imaging as measured by magnetic resonance imaging (MRI) could potentially contribute when making such predictions. It is unclear if the predictive performance of MRI can be
Reconfigurable surface (RS) has been shown to be an effective solution for improving wireless communication links in general multi-user multiple-input multiple-output (MU-MIMO) setting. Current research efforts have been largely directed towards the study of reconfigurable intelligent surface (RIS), which corresponds to an RS made of passive reconfigurable elements with only phase shifting capabil
In this paper, we investigate the problem of decoder error propagation for spatially coupled low-density parity-check (SC-LDPC) codes with sliding window decoding (SWD). This problem typically manifests itself at signal-to-noise ratios (SNRs) close to capacity under low-latency operating conditions. In this case, infrequent but severe decoder error propagation can sometimes occur. To help understa
Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar
Nudging, i.e. the framing of decision environments to exploit known behavioral biases in order to induce certain outcomes, has received considerable attention as a potential policy tool in recent years. Motivated as preserving freedom of choice while making people better off according to their own judgment, nudging seemingly comes at fairly little responsibility for the nudger, i.e. policy makers,
Massively parallel sequencing (MPS) is increasingly applied in forensic short tandem repeat (STR) analysis. The presence of stutter artefacts and other PCR or sequencing errors in the MPS-STR data partly limits the detection of low DNA amounts, e.g., in complex mixtures. Unique molecular identifiers (UMIs) have been applied in several scientific fields to reduce noise in sequencing. UMIs consist o
Aim: Ultraviolet B (UVB) radiation can compromise the functionality of the skin barrier through various mechanisms. We hypothesize that UVB induce photochemical alterations in the components of the outermost layer of the skin, known as the stratum corneum (SC), and modulate its antioxidative defense mechanisms. Catalase is a well-known antioxidative enzyme found in the SC where it acts to scavenge
