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The susceptibility to urinary tract infection (UTI) is controlled by the innate immune response and Toll like receptors (TLRs) are the sentinels of this response. If productive, TLR4 signalling may initiate the symptomatic disease process. In the absence of TLR4 signalling the infected host instead develops an asymptomatic carrier state. The activation of mucosal TLR4 is also influenced by the pro
We consider distributed consensus in networks where the agents have integrator dynamics of order two or higher (n≥2). We assume all feedback to be localized in the sense that each agent has a bounded number of neighbors and consider a scaling of the network through the addition of agents in a modular manner, i.e., without re-tuning controller gains upon addition. We show that standard consensus al
Objectives Registries have been highlighted as means to improve quality of care. Here, we describe temporal trends in risk factors, lifestyle and preventive medication for patients after myocardial infarction (MI) registered in the quality registry Swedish Web-system for Enhancement and Development of Evidence-based care in Heart disease Evaluated According to Recommended Therapies (SWEDEHEART). D
Adolescence is a period of significant physiological changes, and likely a sensitive window to chemical exposure. Few nation-wide population-based studies of chemical body burdens in adolescents have been published. In the national dietary survey Riksmaten Adolescents (RMA) 2016–17, over 13 chemical substance groups, including elements, chlorinated/brominated/fluorinated persistent organic polluta
Control theory allows one to design controllers that are robust to external disturbances, model simplification, and modelling inaccuracy. Researchers have investigated whether the robustness carries on to the controller’s digital implementation, mostly looking at how the controller reacts to either communication or computational problems. Communication problems are typically modelled using random
Shape control strategies seek to bring deformable objects towards a desired target shape. However, conventional methods focus on reaching the target shape without considering the extent to which the object is deformed during the control process. Control actions may generate unnecessary deformations and thus, increase the possibility of object over-stressing and failure. In this letter, we tackle t
Control systems are ubiquitous and often at the core of Cyber-Physical Systems, like cars and aeroplanes. They are implemented as embedded software, that interacts in closed loop with the physical world through sensors and actuators. As a consequence, the software cannot just be tested in isolation. To close the loop in a testing environment and root causing failure generated by different parts of
Environmental concerns such as global warming, the surge of crude oil prices and more stringent emission regulations are demanding the development of internal combustion engines that are highly efficient and low polluting. With classical internal combustion engine concepts such as diesel compression ignition and gasoline spark ignition engines, a trade-off exists between local and global emissions
This paper reports tentatively some features of Semnam, a Central Aslian language spoken by some 250 people in the Perak valley, Peninsular Malaysia. It outlines the unusually rich phonemic system of this hitherto undescribed language (e.g. a vowel system comprising 36 distinctive nuclei), and proposes a practical orthography for it. It also includes the c. 1,250- item wordlist on which the analys
Background and purpose — Total knee replacement (TKR) studies usually analyze all-cause revision when con-sidering relationships with patient and prosthesis factors. We studied how these factors impact different revision diagnoses. Patients and methods — We used data from 2003 to 2019 of TKR for osteoarthritis from the arthroplasty regis-tries of Sweden, Australia, and Kaiser Permanente, USA to st
Background: European treatment guidelines recommend prasugrel over ticagrelor for treating patients with non–ST-elevation acute coronary syndrome (ACS), prompting several Swedish administrative regions to transition from ticagrelor to prasugrel as the preferred treatment for patients with ACS. We aim to systematically evaluate this transition to determine the relative efficacy of prasugrel versus
