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Recent studies in animal models of Parkinson's disease (PD) have provided evidence that dopamine released from spared serotonin afferents can act as a trigger of dyskinetic movements induced by repetitive, low doses of levodopa. Serotonin neurons have the capacity to store and release dopamine synthesized from systemically administered levodopa. However, because of the lack of any autoregulatory f
To support occupations outside the home for older people with functional limitations it is important to understand how the person, environment, and occupations influence performance. Therefore the purpose of this study was to describe how very old people experience occupational performance outside the home. Twenty-one single-living, very old persons, above 80 years, were strategically selected and
Quality is an aspect of high importance in software development projects. The software organizations have to ensure that the quality of their developed products is what the customers expect. Thus, the organizations have to verify that the product is functioning as expected and validate that the product is what the customers expect. Empirical studies have shown that in many software development pro
The World Health Organization (WHO) tuberculosis (TB) symptom screening instrument (WHO-TB) can identify human immunodeficiency virus (HIV)-infected individuals at low risk of tuberculosis (TB); however, many patients report WHO-TB symptoms and require further TB investigations. We hypothesized that further clinical scoring could classify subjects with a positive WHO-TB screening result (WHO-TB(+)
Employing new measures (Implicit Association Test) to study the classic issue of moral orientations, we predicted and found gender differences in implicit associations to the concepts of justice and care. Specifically, we found that men more strongly associate justice vs. care with importance and with themselves than women. However, participants’ explicit ratings did not reveal any clear patterns
Examining the coverage in seven major Japanese and Taiwanese daily newspapers of a selection of events involving both societies in the first decade of the twenty-first century, this paper investigates the phenomenon of rhetorical instrumentalization of the past for present ideological purposes. The concerns of this study are the processes of dehistorization in Japanese and Taiwanese news and publi
The role of airway clearance in inhaled drug therapy is complex. Disease-induced bronchoconstriction results in a central drug-deposition pattern where mucociliary clearance is most efficient. When drug-induced bronchodilation is achieved, deposition and uptake becomes more peripheral, and because there is less mucociliary clearance in the periphery, this will lead to an unintentional increase in
Objectives. We sought to study the relationship between left ventricular ejection fraction (LVEF) and infarct size in patients with ischemic heart disease (IHD) using magnetic resonance imaging (MRI), and to determine a dysfunction index based on the maximum possible LVEF in relation to infarct size. Design. In 149 patients with chronic IHD, LVEF and infarct size were quantified by MRI. Dysfunctio
B cell homeostasis is regulated by multiple signaling processes, including nuclear factor-kappaB (NF-kappaB), BAFF-, and B cell receptor signaling. Conditional disruption of genes involved in these pathways has shed light on the mechanisms governing signaling from the cell surface to the nucleus. We describe a novel mouse strain that expresses solely and excessively a naturally occurring splice va
This thesis investigates the relationship between eye movements, mental imagery and memory retrieval in four studies based on eye-tracking experiments. The first study is an investigation of eye movements during mental imagery elicited both visually and verbally. The use of complex stimuli and the development of a novel method where eye movements are recorded concurrently with verbal data enabled
Objective: The etiology of abdominal aortic aneurysm (AAA) includes atherosclerotic, inflammatory, immunological and coagulatory mechanisms. The aim of this study was to evaluate associations between markers for some of these mechanisms and AAA-size, in order to identify markers which might later be evaluated in relation to aneurysm growth. Material and methods: Prospectively 360 AAA-patients and
The present study investigated whether the rotation rate induced by amphetamine in 6-OHDA-lesioned rats was predictive of development of l-DOPA-induced dyskinesia (LID) and success of the lesion procedure in our experimental settings. We collected data from 312 6-OHDA-lesioned rats (from different sets of experiments). Rats were subjected to the amphetamine-induced rotation test (2.5mg/kg) and chr
This dissertation is an anthropological study of war and violence in the volatile eastern territories of the Democratic Republic of Congo. The ethnographic focus is on one of the largest rebel groups currently operating in the Congo conflicts, the Hutu-dominated Democratic Forces for the Liberation of Rwanda (FDLR). These Hutu rebels arrived in the Congo in 1994, after the genocide in neighboring
