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Little is known on the spreading capacities of Limnomonas gaiensis across freshwater lakes in Northern Europe. In this study, we show that the species could successfully be aerosolized from water sources by bubble bursting (2-40 particles.cm−3), irrespectively of its density in the water source or of the jet velocity used to simulate wave breaking. The species viability was impacted by both water
Ketamine is a common anesthetic used in human and veterinary medicine. This drug has recently received increased medical and scientific attention due to its indications for neurological diseases. Despite being applied for decades, ketamine’s entire metabolism and pharmacological profile have not been elucidated yet. Therefore, insights into the metabolism and brain distribution are important towar
The rapid advancement of imaging technologies in pathology has ushered in an era of data-intensive diagnostic workflows, generating large volumes of data that demand sophisticated segmentation and compression techniques. Chemical imaging approaches offer an all-digital objective approach to pathological analysis, though image segmentation is required for efficient computation. Convolutional autoen
’Screen time’ has become a catch-all concept for debates on people’s dependence of digital devices in general, and children’s use of media technology in particular, almost exclusively focusing on negative consequences. While children and young people more often than not are at the center of debates around screen time, parents and their everyday practices are held accountable for monitoring, regula
Inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate reductase (GMPR) belong to the same structural family, share a common set of catalytic residues and bind the same ligands. The structural and mechanistic features that determine reaction outcome in the IMPDH and GMPR family have not been identified. Here we show that the GMPR reaction uses the same intermediate E-XMP* as IMPDH
Every two weeks, one of the world’s estimated 7,000 languages dies. Yet what are the consequences of having to give up one’s native language? Speakers of minority languages worldwide face barriers to using their languages outside their homes, often with negative consequences for educational and economic success. A new survey of the Indigenous Sámi in Sweden and Norway suggests that language polici
We study how co-creation practices influence explorative and exploitative learning in five collaborative construction projects with partnering arrangements. Drawing on a longitudinal case study, our findings reveal two different types of explorative learning processes (i.e., adaptation and radical development) and three different exploitative learning processes (i.e., incremental development, know
Gymnasie- och universitetsutbildning var länge en elitens domän. Med ekonomisk tillväxt och ökande teknisk komplexitet växte dock behovet av specialiserad kunskap och färdigheter. Inför och under industrialiseringen tog systemen för högre utbildning emot ett ökande antal studenter och breddades med ett växande utbud av kurser och typer av utbildningsinstitutioner.Danmark, Norge och Sverige utgör rHigh school and university-level education was long an elite pursuit. However, with economic growth and rising technical complexity, the need for specialised knowledge and skills increased. In the run-up to and during industrialisation, higher education systems admitted a growing number of students and diversified across an increasing range of courses and types of educational institutions.Denmark,
Background: Road-traffic noise may influence the development of cardiovascular events such as stroke and myocardial infarction, but etiological mechanisms remain unclear. This study aimed to assess the relationship between long-term road-traffic noise exposure and coronary atherosclerosis in Sweden. Methods: In the Swedish CArdioPulmonary bioImage Study (SCAPIS) cohort, including 30,154 subjects a
The development of replacing human organs with those from genetically modified pigs holds immense potential for alleviating the shortage of organs necessary for patients in need of transplants. This medical advancement is also accompanied by significant social changes, including the emergence of a bioeconomy, new modes of biotechnology governance, altered human-animal relations and increased publi
Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication that seriously endangers maternal and infant health, posing a medical and economic burden worldwide. Several dietary patterns have been recommended for women of childbearing age, demonstrating a positive role in preventing and managing GDM. However, these dietary patterns may not fully take environmental factors into account
One of the most pressing questions we face as biologists is to understand how climate change will affect the evolutionary dynamics of natural populations and how these dynamics will in turn affect population recovery. Increasing evidence shows that sexual selection favors population viability and local adaptation. However, sexual selection can also foster sexual conflict and drive the evolution of
Assays for quantifying aggregated and phosphorylated (S129) human α-synuclein protein are widely used to evaluate pathological burden in patients suffering from synucleinopathy disorders. Many of these assays, however, do not cross-react with mouse α-synuclein or exhibit poor sensitivity for this target, which is problematic considering the preponderance of mouse models at the forefront of pre-cli
DNA-binding proteins play an important role in gene regulation and cellular function. The transcription factors MarA and Rob are two homologous members of the AraC/XylS family that regulate multidrug resistance. They share a common DNA-binding domain, and Rob possesses an additional C-terminal domain that permits binding of low-molecular weight effectors. Both proteins possess two helix-turn-helix
Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and carbonates. Structurally, PON1 is a six-bladed β-propeller with a flexible loop (residues 70-81) covering the active site. This loop contains a functionally critical Tyr at position 71. We have performed detailed experimental and computational a
