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Objective: To estimate the cost-effectiveness of treating ankylosing spondylitis (AS) with infliximab (Remicade(R)) in Spain for up to 40 years. Methods: A previously published disease model was adapted to the Spanish setting using resource consumption from a cross-sectional burden of an illness study in 601 patients in Spain. Cost-effectiveness estimates were based on a placebo-controlled clinica
Using the metrics of channel capacity and multiplexing efficiency, the adaptive impedance matching (AIM) performances of two multiple-input multiple-output (MIMO) terminals with different antenna designs were evaluated and compared. The evaluation was performed in LTE Band 18 Downlink (860-875 MHz) under realistic usage conditions of two measured user handgrips and simulated propagation channels w
Men with germline breast cancer 1, early onset (BRCA1) or breast cancer 2, early onset (BRCA2) gene mutations have a higher risk of developing prostate cancer (PCa) than noncarriers. IMPACT (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in BRCA1/2 mutation carriers and controls) is an international consortium of 62 centres in 20 countries evaluating the
BACKGROUND: Normal cell division is coordinated by a bipolar mitotic spindle, ensuring symmetrical segregation of chromosomes. Cancer cells, however, occasionally divide into three or more directions. Such multipolar mitoses have been proposed to generate genetic diversity and thereby contribute to clonal evolution. However, this notion has been little validated experimentally. PRINCIPAL FINDINGS:
In the northern Gulf of Mexico (nGoM), the Louisiana Shelf (LS) and Mississippi Bight (MB) subregions are influenced by eutrophication to varying degrees. Despite recognition that dissolved silicon may regulate diatom productivity in the nGoM, there is only one published data set reporting biogenic silica (bSiO2) production rates for each subregion. We report that bSiO2 production rates on the LS
Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient availability of biomarkers represents a significant gap in understanding the disease cause and progression. We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. Untargeted proteomics of 2,252 samples from 184 individuals identify 376 re
In this paper, we show that a software implementation of IND-CCA-secure Saber key encapsulation mechanism protected by first-order masking and shuffling can be broken by deep learning-based power analysis. Using an ensemble of deep neural networks trained at the profiling stage, we can recover the session key and the secret key from 257 × N and 24 × 257 × N traces, respectively, where N is the num
The diverse, largely Neotropical subtribe Euptychiina is widely regarded as one of the most taxonomically challenging groups among all butterflies. Over the last two decades, morphological and molecular studies have revealed widespread paraphyly and polyphyly among genera, and a comprehensive, robust phylogenetic hypothesis is needed to build a firm generic classification to support ongoing taxono
Purpose: This study aimed to quantify the relationship between objective and subjective measures of functional ability and determine if measures in the deficient (ACLd) state were correlated to, and capable of predicting a patient's objective and subjective measures in the reconstructed (ACLr) state. Methods: Twenty ACL-injured participants completed hop and side cut movements prior to and 10 mont
Misuse resilience is an important security criterion in the evaluation of the NIST Post-quantum cryptography standardization process. In this paper, we propose new key mismatch attacks against Kyber and Saber, NIST's selected scheme for encryption and one of the finalists in the third round of the NIST competition, respectively. Our novel idea is to recover partial information of multiple secret e
Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be important. Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide pol
We study the notion of anonymous credentials with Publicly Auditable Privacy Revocation (PAPR). PAPR credentials simultaneously provide conditional user privacy and auditable privacy revocation. The first property implies that users keep their identity private when authenticating unless and until an appointed authority requests to revoke this privacy, retroactively. The second property enforces th
In this paper, we present the first chosen-ciphertext (CC) cache-timing attacks on the reference implementation of HQC. We build a cache-timing based distinguisher for implementing a plaintext-checking (PC) oracle. The PC oracle uses side-channel information to check if a given ciphertext decrypts to a given message. This is done by identifying a vulnerability during the generating process of two
This book constitutes the refereed proceedings of the 14th International Workshop on Post-Quantum Cryptography, PQCrypto 2022, held in College Park, MD, USA, in August 14–18, 2023.The 25 full papers presented in this book were carefully reviewed and selected from 51 submissions. They are categorized in the following topical sections: code-based cryptography; group-action-based cryptography; isogen
Pseudo-random functions are a fundamental building block in many cryptographic applications. In certain scenarios, a weaker notion (where security is restricted to uniformly random input), but more computationally efficient, called weak pseudo-random functions, is sufficient. In this work, we present new differential attacks on the main binary weak pseudo-random function constructions, namely the
We designed and simulated a 1 GHz planar dipole antenna that is cloaked in a band around 10 GHz. Relative to an uncloaked antenna it has a reduced extinction cross-section for the co-antenna polarization, at the cost of an increased cross-polarization. This reduced extinction cross-section characterizes a reduction in scattering and absorption, and so reduced interference to electromagnetic waves
Connected and automated vehicles (CAVs) will be a key component of future cooperative intelligent transportation systems (C-ITS). Since the adoption of C-ITS is not foreseen to happen instantly, not all of its elements are going to be connected at the early deployment stages. We consider a scenario where vehicles approaching a traffic light are connected to each other, but the traffic light itself
A memetic framework for optimal inverse design is proposed by combining a local gradient-based procedure and a robust global scheme. The procedure is based on method-of-moments matrices and does not demand full inversion of a system matrix. Fundamental bounds are evaluated for all optimized metrics in the same manner, providing natural stopping criteria and quality measures for realized devices. C
This thesis unfolds a journey into the realm of cloud integrated systems. More specifically, it explores the transformational role of diverse cloud infrastructure, be it public or private, centralized or edge-based, when integrated into traditional systems. In this transformation, the cloud assumes the vital role of controllers. Inevitably, this shift towards cloud integration also brings into pla
