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Antibodies are important proteins participating in a number of reactions to protect us from harmful diseases. Apart from this important function, they are also useful in different technical and medical applications. This, however, relies on our possibility to produce antibodies in vitro. In the first part of my thesis a new technology called CDR shuffling was developed to create diverse and highly
Popular Abstract in Swedish På grund av befolkningsutvecklingen de närmaste åren kommer långt fler äldre människor än idag att bo kvar i vanliga bostäder, även om de särskilda boendeformerna byggts ut i snabb takt. För att underlätta kvarboende måste den fysiska boendemiljön motsvara de krav som ställs på grund av åldersförändringar och då hjälpbehov uppkommer. Arbetsterapeuter har, bl a genom erfThe general aim of this thesis was to explore relationships between functional capacity, environmental factors, everyday activity, and health in the elderly population. Initially, the Enabler, an instrument for assessment of the physical home environment's accessibility, was translated to Swedish and revised, and tested for reliability and validity. Further, a systematic random sample of individua
Syftet med detta projekt var att studera samspelet mellan friktion, balansförmåga och halkrisker, samt att ta fram designrekommendationer för friktionskrav och halksäkrare skor och underlag. Sex studier har utförts innefattande friktionsmätningar av skor på olika underlag och temperaturer, studier av stående balans och gång på ramp med justerbar lutning samt fokusgruppintervjuer. Resultaten visar
Succinate:quinone reductase (SQR) is an enzyme in the respiratory system of aerobic cells. SQR catalyzes two reactions, the oxidation of succinate to fumarate and the reduction of quinone to quinol. These reactions are coupled by electron transfer within the enzyme from the site of succinate oxidation to the site of quinone reduction. Some enzymes reduce ubiquinone (exergonic reaction) whereas oth
While the inventor is often the driver of an invention in the early stages, he/she needs to move between different social networks for knowledge in order to create and capture value. The main objective of this research is to propose a literature-based framework based on innovation network theory and complemented with C-K theory, in order to analyze the invention/innovation process of inventors and
The Germanic V2 languages differ from English and Italian in not allowing backward binding. In this paper I have tried to account for this cross-linguistic variation in terms of a recent proposal by Chomsky (2008) that A-chains and A-bar chains should be held strictly apart, and that A-movement and A-bar movement sometimes may take place in parallel. With respect to backward binding, I have claime
We have discovered four extremely surprising emission lines of strontiumin ejecta near eta Carinae. Hubble Space Telescope (HST) SpaceTelescope Imaging Spectrograph (STIS) observations made in 1999 show twonarrow features whose wavelengths correspond to the forbiddentransitions of Sr II, and we have found no other plausibleidentification for these lines. The identifications are confirmed by newHST
Abstract is not available
This dissertation draws on postcolonial understandings in order to offer a sociological analysis of Lebanese immigrants in Montreal, New York City and Paris. I argue that the concept of diaspora provides a framework for understanding Lebanese immigrant experiences, as some immigrants may undergo a process of assimilation while others continue to hold on to their ethnic identities. Proposing that “
The Malay Peninsula is a crossroads for people, languages and cultural influences, apparent in today's vibrant mix of Malay, Chinese, Indian, Thai and European. Yet this modern state of affairs all but conceals signals of much older situations of diversity. Thus, some 140,000 people grouped together under the label Orang Asli (Malay for 'aboriginal people') represent a range of cultural and biolog
The thesis scrutinizes an emerging phenomenon in international relations: the increase in functional overlaps among international regimes. I approach this young field of study in three consecutive parts. The first part conceptualizes regime overlaps as ‘regime conflicts’. Following a broad sociological understanding of ‘conflict’, I define a regime conflict as an overlap among two or more internat
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Insulin är ett hormon som utsöndras från bukspottkörteln när koncentrationen av näringsämnen stiger i blodet. Insulinet transporteras via blodbanan till sina målvävnader; levern, skelettmusklerna och fettväven. Där binder det till insulinreceptorer på cellernas yta och insulinet medierar på så vis en rad olika effekter. Främst stimulerType 2 Diabetes is a disorder that increases globally, but mainly in the western world. One of the hallmarks of Type 2 diabetes is insulin resistance in the target tissues of insulin action (adipose tissue, liver and skeletal muscle). In addition, most patients with Type 2 diabetes are obese. Increased release of free fatty acids from the enlarged and/or dysfunctional adipose tissue is suggested t
