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Mitochondrial permeability transition (MPT) is induced in isolated brain mitochondria by calcium and oxidants and is inhibited by adenine nucleotides. When induced, MPT is associated with equilibration of solutes of <1500 Da across the inner mitochondrial membrane. A persistent induction of MPT depolarizes the inner membrane and causes cessation of ATP synthesis, swelling of the matrix, and bursti
This doctoral thesis has its theoretical origin in the notion that the information flow between management teams, financial analysts and investors is especially exposed to information asymmetry when knowledge-intense companies are concerned. Information asymmetry may aggravate agency problems and risk causing an impairment of the efficient allocation of capital on the stock market. Therefore, the
This article analyses the doctrine of free will (autexousion) in the confessions of St. Peter Mogila and Dositheos II Notaras of Jerusalem. Free will is a central concept in Eastern Christian anthropology and these two monuments of theology represent how the understanding of the concept of free will developed in Eastern Orthodox theology in the context of the confrontation with Western theologies
Popular Abstract in Swedish I hjärnan finns ett fantastiskt effektivt kontrollsystem för utförandet av olika typer av rörelser. Lillhjärnan är en viktig del av detta kontrollsystem eftersom skador på lillhjärnan kan leda till att fint styrda rörelser blir svårare eller kanske helt omöjliga att utföra. En förståelse av lillhjärnans funktion kan därför leda till en bättre generell förståelse av hur A modular organization has recently been described for the cerebellar control system comprising the forelimb areas of the C1/C3/Y zones in the cerebellar cortex and nucleus interpositus anterior (NIA) of the cat. A module is a group of cells in NIA which receives homogenous climbing fibre input via Purkinje cells that belong to the same set of microzones in the C1/C3/Y zones. The organization of i
This paper describes in what ways hierarchical organizations influence the utilization and dissemination of knowledge. Particular attention will be paid to the role that tacit knowledge has. The reporting system of incidents is one element in a larger institutional process, often termed 'lessons learned' (LL). This process helps to suggest solutions to identify shortcomings and facilitates in maki
The Conference on Computational Natural Language Learning is accompanied every year by a shared task whose purpose is to promote natural language processing applications and evaluate them in a standard setting. In 2008 the shared task was dedicated to the joint parsing of syntactic and semantic dependencies. This shared task not only unifies the shared tasks of the previous four years under a uniq
Popular Abstract in Swedish Författaren utarbetar och försvarar en version av kantiansk etik som utgår från Kants tanke att det enda som har absolut värde är den goda viljan och att det högsta goda för människor därmed består i dygd samt lycka i proportion till dygd. Avhandlingen består av två huvudsakliga delar, dels en allmän genomgång av vad det innebär att vara en person, dvs en varelse som inThis work seeks to develop a Kantian ethical theory in terms of a general ontology of values and norms together with a metaphysics of the person that makes sense of this ontology. It takes as its starting point Kant’s assertion that a good will is the only thing that has an unconditioned value and his accompanying view that the highest good consists in virtue and happiness in proportion to virtue.
This article deals with the establishment of auteurist criticism in early 1950s Britain, particularly emphasizing the role played by Oxford university film journal Sequence and the writings of future film director Lindsay Anderson.
Popular Abstract in Swedish Jäst kan antingen bryta ner socker direkt till koldioxid och vatten genom andning, eller indirekt via koldioxid och etanol, genom jäsning. Andning är en process som förbrukar syre, och sker därför endast under syrerika (aeroba) förhållanden. Jäsning kräver till skillnad från andning inte tillgång till syre, och kan därför ske under syrefattiga (anaeroba) förhållanden. Under aerobic conditions, most yeasts such as Kluyveromyces lactis, prefer the respiratory pathway and some, such as Saccharomyces cerevisiae prefer less energy efficient fermentative pathway for their energy metabolism. These two metabolic strategies are also known as Crabtree negative and Crabtree positive respectively, and the evolution of the latter has lately been explained by the “make-accum
This article describes the interactive instrument/sound installation etherSound and discusses its artistic and ethical implications. etherSound is a work in progress and the main intent is to create a vehicle for audience participation through the use of SMS (Short Message Service). The two different contexts in which etherSound has been tried (in concert with performers and as a sound installatio
Popular Abstract in Swedish Blodomloppet innesluts av kroppens kärlsystem och ombesörjer tillförsel av näringsämnen och syre till kroppens organ och vävnader. Det svarar också för borttransport av slaggprodukter och syretömda röda blodkroppar tillbaka till lungorna för ”omladdning”. Inget organ fungerar bättre än vad som dess blodförsörjning tillåter. Våra organ och vävnader säkrar därför sin egenAngiotensin II (Ang II) is a potent vasoconstrictor that is implicated in the pathogenesis of hypertension, heart failure and atherosclerosis. In this thesis, the efficacy and safety of Ang II receptor blockers (ARB) were evaluated. The vasomotor effects of Ang II in endothelium-denuded human coronary arteries were characterized by in vitro pharmacology and the Ang II receptor mRNA levels were qua
