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The human B1 bradykinin (BK) receptor (B1R) is more efficacious than the human B2 BK receptor (B2R) in both ligand-independent and agonist-dependent coupling to Gq/11-mediated phospholipase Cβ activity. In fact, B1R is constitutively active, whereas B2R exhibits little if any constitutive activity. To evaluate the role of the C-terminal domain in receptor Gq/11 coupling, we constructed chimeric an

In five primary hip arthroplasties and in six revisions with impacted, morselized allografts and cement, roentgen stereophotogrammetric analysis (RSA) was planned to be used to measure the subsidence of the polished and double-tapered Exeter femoral stem, relative both to the cement and the femur. Only in two primary arthroplasties and in two revisions could the tantalum markers be adequately imag

Urban pedestrian-level air quality is a result of an interplay between turbulent dispersion conditions, background concentrations, and heterogeneous local emissions of air pollutants and their transformation processes. Still, the complexity of these interactions cannot be resolved by the commonly used air quality models. By embedding the sectional aerosol module SALSA2.0 into the large-eddy simula

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since 2014 July. This paper describes the second data release from this phase, and the 14th from SDSS overall (making this Data Release Fourteen or DR14). This release makes the data taken by SDSS-IV in its first two years of operation (2014-2016 July) public. Like all previous SDSS releases, DR14 is cumulative,

While research on the design of heterogeneous concurrent systems has a long and rich history, a unified design methodology and tool support has not emerged so far, and thus the creation of such systems remains a difficult, time-consuming and error-prone process. The absence of principled support for system evaluation and optimization at high abstraction levels makes the quality of the resulting im

Several commercial UF-membranes are characterized by water contact angles. Two different methods of contact angle measurements, the sessile drop and the captive bubble methods, are compared. Differences in results between the two methods occur for the DDS GR 61 membrane; otherwise the methods give rather consistent results. The advancing and the receding contact angles are measured for the UF-memb

This pilot study aimed to investigate whether mammographic compression procedures might cause shedding of tumor cells into the circulatory system as reflected by circulating tumor cell (CTC) count in peripheral venous blood samples. From March to October 2012, 24 subjects with strong suspicion of breast malignancy were included in the study. Peripheral blood samples were acquired before and after

IMPORTANCE: Correct diagnosis of ovarian cancer results in better prognosis. Adnexal lesions can be stratified into the Ovarian-Adnexal Reporting and Data System (O-RADS) risk of malignancy categories with either the O-RADS lexicon, proposed by the American College of Radiology, or the International Ovarian Tumor Analysis (IOTA) 2-step strategy.OBJECTIVE: To investigate the diagnostic performance

The results of a search for electroweakino pair production pp→χ~1±χ~20 in which the chargino (χ~1±) decays into a W boson and the lightest neutralino (χ~10), while the heavier neutralino (χ~20) decays into the Standard Model 125 GeV Higgs boson and a second χ~10 are presented. The signal selection requires a pair of b-tagged jets consistent with those from a Higgs boson decay, and either an electr

To study the role of the mossy fiber afferents to the cerebellum in classical eye-blink conditioning, in particular the timing of the conditioned responses, we compared the effects of varying a peripheral conditioned stimulus with the effects of corresponding variations of direct stimulation of the mossy fibers. In one set of experiments, decerebrate ferrets were trained in a Pavlovian eye-blink c

This article reflects on Max Weber’s idea of disenchantment in relation to the material turn within contemporary religious studies. In the first part, I return to the two most famous texts in which Weber uses the concept, with particular attention to the historical context in which these texts were penned. In the following part, I discuss some of the contemporary efforts to engage critically with

Objective In this study we aimed to estimate the effect of diabetes, educational level and income on the risk of mortality and cardiovascular events in primary care patients with hypertension. Methods We followed 62,557 individuals with hypertension diagnosed 2001-2008, in the Swedish Primary Care Cardiovascular Database. Study outcomes were death, myocardial infarction, and ischemic stroke, asses

In this 2 hour workshop the experiences of the geographic data domain will be shared with the open data research & education community to promote and strengthen active innovative learning and teaching in both worlds. The domain of geographic data can be considered as one of the front running in open data. Over the past two decades, many geographic datasets in Europe became available as open da

Artikeln behandlar utsignalåterkoppling av system där funktionen som avbildar tillstånden på mätsignarlerna har en mängdvärd invers.Vi visar att om mängden har begränsad kardinalitet, så går det att komprimera historiken till en ändlig vektor som beräknas rekursivt.Resultatet exemplifieras på diskrettidsintegratorn där mätsignalen är absolutbeloppet av tillståndet och får fram en förvånandsvärt enThis article considers output-feedback control of systems where the function mapping states to measurements has a set-valued inverse. We show that if the set has a bounded number of elements, then minimax dual control of such systems admits finite-dimensional information states. We specialize our results to a discrete-time integrator with magnitude measurements and derive a surprisingly simple sub

The conference "Towards a Global Diplomatic History (c.1400-1900)" held on 30-31 May 2024 at the University of Warwick, intended to redefine the conventional Eurocentric narrative of diplomatic history. Traditionally, the history of diplomacy has been portrayed as a European-centric story, highlighting the city-states of Renaissance Italy, the Westphalian system, the rise of the modern nation-stat

Island chains provide access to terrestrial, coastal and offshore marine resources, attracting peoples and cultures and serving as conduits for migrations and long-distance exchange networks. Situated between Hokkaido and Sakhalin, Rebun Island connected the prehistoric cultures of northeast Asia in a major “marine highway”. Rebun was repeatedly settled by distinct cultures who originated in diffe

Kolinfosfolipider, en nyttig kostkomponent vid alkoholfettlever, NAFLD och NASH?Åke Nilsson, Rui-Dong DuanBakgrundKolin (trimetyletanolamin) ingår i fosfatidylkolin (PC) och sfingomyelin (SM) som finns i alla cellmembraner och i plasmalipoproteiner, och i acetylkolin. Även om levern bildar en del kolin klassas kolin som ett essentiellt näringsämne. Kolinbrist ger bl a fettlever, muskelsymptom och

Based on a study of nurses’ social media uses during the pandemic, this article aims to illuminate how nurses used social media to position themselves as nurses and safeguard the nursing profession. Thirty semi-structured interviews were conducted with nurses in the three Scandinavian countries. Data were thematically analysed, with theoretical inspiration from Berger and Luckmann (1966). The find