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BACKGROUND: There is an increasing interest in cognitive and functional outcomes in the respective stages of Alzheimer's disease (AD) and in novel therapies particularly for the milder phases of AD. Our aim was to describe and compare various aspects of disease progression in patients with mild versus moderate AD in routine clinical practice of cholinesterase inhibitor (ChEI) therapy. METHODS: Thi
Background: Selective dorsal rhizotomy (SDR) is a well accepted neurosurgical procedure performed for the relief of spasticity interfering with motor function in children with spastic cerebral palsy (CP). The goal is to improve function, but long-term outcome studies are rare. The aims of this study were to evaluate long-term functional outcomes, safety and side effects during five postoperative y
Objective. To establish a high-throughput system for testing the ability of drugs or monoclonal antibodies to reduce the in vitro formation of cystatin C dimers to identify substances potentially useful for treatment of patients with hereditary cystatin C amyloid angiopathy (HCCAA). Methods. Various combinations of incubation temperature, time period, guanidinium chloride concentration and concent
Radiochromic film, polymer gel and radiochromic plastic are three different kinds of dosimeters developed for radiation therapy and suitable for optical readout. In this study, different optical CT scanners are used to scan the dosimeters to find out if they could be used as multi-purpose scanners, i.e. for readout of the different kinds of dosimeters. Promising results are found but further devel
OBJECTIVE Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise beta-cell function in a Phase II clinical trial. GADA affinity has been shown
Background: Frontotemporal dementia (FTD) is recognised as a clinically and morphologically heterogeneous group of interrelated neurodegenerative conditions. One of the subtypes within this disease spectrum is the behavioural variant FTD (bvFTD). This is known to be a varied disorder with a mixture of tau-positive and tau-negative underlying pathologies. The other subtypes include semantic dementi
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen i världen bland kvinnor och bara i Sverige insjuknar varje år runt 7000 personer. Vi vet att omkring 10-15% av fallen troligen beror på ärftliga faktorer och det har under senare tid gjorts stora insatser för att klargöra exakt vilka arvsanlag som har betydelse för utveckling av sjukdomen. Under början av 90-talet identifieradeHereditary breast cancer constitutes a considerable fraction of the total number of breast cancer cases occurring each year. Up until recently very few breast cancer predisposing genes were known, but many new common polymorphisms contributing to increased cancer susceptibility are continuously being identified. This thesis has focused on familial breast cancer and identifying as well as investi
The conditions for trading differ in the EU, even though the idea of the single market was born almost six decades ago and started to go toward completion over two decades ago. These differences causes asymmetry in trade costs which lead to trade volumes, and in extension wealth, are less in the union than what they would be if the union was more harmonized. This paper is therefore aiming at findi
Mål rörande rena utflyttningsskatter har det senaste decenniet varit tämligen frekvent förekommande i EU-domstolen. Detta har i sin tur medfört att, b.la, Kommissionens fokus har riktats gentemot ifrågakommande medlemsstaters utformning/tillämpning av denna typ av skatter då medlemsstaterna i sin strävan att skydda sina respektive skattebaser gärna använder sig av utflyttningsskatter i olika utforOver the last decade there has been an increase in the number of cases that are referred to the Court of Justice of the European Union (CJEU) with regards to matters of exit taxes. Consequently, this has turned the Commission’s focus towards the outline of the respective exit tax regimes applied in the different Member States (MS). This since the MS, in their efforts to protect their respective ta
Popular summary The fate of non-steroidal anti-inflammatory drugs The knowledge about distribution of drugs between sewage sludge, water phases and water living organisms is vital for predictions of the fate and transport routes of toxic substances to the environment. And the distribution of drugs in the environment can be used as a base for risk assessments and it also can be used to define desir
Populärvetenskaplig sammanfattning: Är klimatforskningen skev? En central fråga är om vi kan lita på att vetenskapliga tidskrifter återger en rättvis bild av aktuella forskningsresultat? Dessutom bör vi fråga oss hur rapporteringen påverkas då betydande händelser sker inom vetenskapsvärlden. I november 2007 och senare 2009 skedde två viktiga företeelser inom klimatforskningen som potentiellt kanAbstract The declaration of a scientific consensus concerning anthropogenic causes for climate change by the IPCC in their fourth assessment report (AR4), published in 2007, initiated a heated debate. During this debate, experts within the IPCC were accused of selective reporting and the AR4 got strong source criticism by politicians, stakeholders and climate skeptics in general. The debate furth
Farm size expansion in some countries in Sub-Saharan Africa, including in Ghana, is a recent phenomenon, and is indicative of the agricultural transformation process taking place in the region. Technology use and adoption level is an integral and complex part of this process, which is studied in relation to the expanding farm sizes and agricultural transformation in this study. It follows an explo
The covid-19 pandemic has left an irreversible impact of an immense magnitude on the world. Over six million people have died after contracting the virus, and millions more are grieving and living with the aftermath of a loss of a family member. In Europe, countries have chosen different ways to tackle and curb the spread of the virus with varying degree of success, In order to save lives, complia
Non-human animals are often excluded from contemporary political theories, much to their detriment in terms of welfare and protection. The ‘political turn’ is a subset of animal ethicists concerned with moving beyond motivating moral status and instead discussing the politics of a shared human-animal society. This thesis evaluates Philip Pettit’s neo-republicanism as a theoretical framework for a
Sedan införandet av det kommunala planmonopolet 1947 till följd av den bostadssociala utredningen har planlagstiftningen reformerats flertalet gånger. I förevarande examensarbete studeras den historiska utvecklingen av både det kommunala planmonopolet och dess tillhörande planlagstiftning. Examensarbetet syftar till att studera hur det kommunala planmonopolet kommit att utvecklas och om reformerSince the introduction of the municipal planning monopoly in 1947 following the Housing Social Investigation, the planning legislation has been reformed several times. In this thesis, the historical development of both the municipal planning monopoly and its associated planning legislation is studied. The aim of the thesis is to examine how the municipal planning monopoly has evolved and whether
This thesis investigates the strategic use of narratives in Chinese Buddhist public diplomacy to support the Belt and Road Initiative (BRI) in Thailand. This study examines the different levels of narrative formation, including system, identity, and issue narratives, to provide a comprehensive understanding of the mechanisms that drive communication, persuasion, and influence in international affa
Overheating in buildings is becoming a major concern and cause for various health issues. Existing research and previous studies on the issue were examined to acquire relevant information about the definition of overheating, its possible causes, and the heath impacts it could have on human health. The review included data on the current status of thermal comfort and overheating regulations in Swed
Okawangodeltat är södra Afrikas största våtmark och en av världens minst påverkade våtmarker. Kunskapen om hur våtmarkssystemet fungerar är begränsad, särskilt vad gäller halter av näringsämnen och omsättning av näringsämnen i de dominerande våtmarksväxterna. I den här studien presenteras analyser av kol- , kväve- och kiselhalter i Cyperus papyrus som är den dominerande akvatiska växten i stora deThe Okavango Delta is southern Africa’s greatest wetland and is among one of the most pristine wetlands in the world. There is moderate information about how this system functions, however, the research on nutrient concentrations and cycles is especially limited. This study provides new knowledge on the Okavango Delta by analysing samples of Cyperus papyrus, one of the main aquatic plants in the a
Scientific information is playing an important role in policymaking on climate adaptation by providing insight and guidance on efforts needed to reduce risks, respond to impacts, and build resilience. However, the extent to which science is influencing policy is questioned, as efforts being made are not reflecting efforts needed. Barriers in the interface between science and policy has found to be
The effect of future changes in temperature and precipitation patterns on arctic ecosystem functioning is often assessed using state-of-the-art ecosystem models. Many models however lack detailed representation of wintertime processes, as pointed out by recent studies (Wang et al. 2016, Slater and Lawrence 2013). This bias may influence the derived outputs, such as soil temperature, permafrost ext
