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AIMS: To evaluate the long-term clinical and economic outcomes associated with insulin detemir and neutral protamine hagedorn (NPH) insulin in combination with mealtime insulin aspart in patients with type 1 diabetes in Sweden, based on data from a two-year, multi-national, open-label, randomized, controlled trial.METHODS: Insulin detemir was associated with significant improvements in glycaemic c
Background/Objectives: The surgeon’s subjective intraoperative evaluation is the standard of care to assess postoperative residual disease (RD) in advanced epithelial ovarian cancer (EOC). We investigated the feasibility of ctDNA as an objective marker for postoperative RD. Methods: This prospective study included 27 patients with advanced ovarian cancer (FIGO IIIA1–IVB) who underwent primary surg
I cirkulära ekonomier förväntas konsumenter förlänga produkters livslängd och säkerställa att de återvinns—en betydande omställning från dagens ekonomiska system där linjära konsumtionssätt dominerar. För att stödja denna omställning behöver vi förstå hur cirkulär konsumtion (o)möjliggörs i olika kontexter som formats av linjär konsumtion, t. ex. detaljhandeln och hushåll. Syftet med denna avhandlIn circular economies, consumers are expected to extend product lifetimes and ensure recycling—a considerable departure from the linear take-make-dispose model. To support this shift, we need to understand how circular consumption is currently enabled in retail markets and how consumers navigate these tasks. Thus, in this dissertation, I aim to explore and conceptualise how circular consumption is
BACKGROUND: The efficacy of corticosteroids for treating acute vestibular neuritis, or acute unilateral vestibulopathy (AUVP), remains controversial.OBJECTIVE: This study aimed to evaluate whether corticosteroids improve vestibular function and reduce symptoms in both acute and chronic phases of AUVP.METHODS: This randomized, placebo-controlled, double-blind trial included patients with AUVP (ages
Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1-FPD), caused by monoallelic deleterious germline RUNX1 variants, is characterized by bleeding diathesis and predisposition for hematologic malignancies, particularly myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Clinical data on FPDMM-associated AML (FPDMM-AML) are limited, complicating evidence
Background and Objectives: Temporomandibular disorders (TMDs) is an umbrella term for pain and dysfunction involving jaw muscles and/or the temporomandibular joint, with whiplash trauma suggested to be one risk factor. The aim was to evaluate prevalence and relative risk of TMDs in the acute and chronic stages after whiplash trauma. Databases and Data Treatment: This review was registered in Prosp
We examine the effect of screen-based activities on obesity and mental well-being for children, using a large survey dataset representative of the UK population and an event study model that exploits exogenous variation in the entry date of the digital television transition in the UK. The digital transition increased the number of available free television channels from 5 to 40, leading to a rise
The effect of measurement errors on adaptive and non-adaptive control charts has been occasionally considered by researchers throughout the years. However, that effect on the variable sample size and sampling interval (VSSI) X¯ control charts has not so far been investigated. In this paper, we evaluate the effect of measurement errors on the VSSI X¯ control charts. After a model development, the e
Over the past years, the natural environment has increasingly become instrumental in peace policies and the focus of study in peace and conflict research. Concurrently, there is mounting global recognition that nature contributes to peoples wellbeing in manifold ways and that incorporating diverse values of nature in policymaking is paramount for sustainable development. At the nexus of current de
This paper makes use of nearly 25,000 observations representing over 95,000 paid workdays across over 300 years to investigate individual work patterns, work availability, and the changes in work seasonality over time. This sample is comprised of workers in the construction industry, and includes unskilled men and women as well as skilled building craftsmen – the industry which is often used to es
Elites are often offered prestigious state prizes and awards. Although most elites accept, prestigious prizes constitute a challenge for others since institutional symbolic capital cannot be merely accepted, but requires careful negotiation and management. This article investigates the dilemma of being consecrated by the state by studying civil society elites’ reception and use of royal honours, t
Cubosomes are non-lamellar lipid nanoparticles that have drawn a significant attention in the field of nanomedicine due to their tunable properties. However, the formation of vesicles during the preparation of cubosomes, and the presence of mixed bicontinuous cubic phases, may lead to artifacts and lack of correlation between the physico-chemical and biological characterization. In this work, we h
Probiotic strains such as Limosilactobacillus reuteri are highly sensitive to thermal, oxidative, and mechanical stress, and freeze-drying has become a standard technique for stabilizing probiotic cultures. The protective performance of the dried product is determined by both its chemical composition and its mechanical structure, with an ideal encapsulating matrix consisting of thick and co
This thesis examines the extent to which EU directives on information and consultation enable employees, through employees’ representatives, to influence employer decision-making before final decisions are adopted, particularly in situations involving restructuring and collective redundancies. The analysis focuses on four central directives within the EU framework: the Information and Consultation
This thesis examines how individuals form and enact political vegan identity through everyday practice, and the role digital media platforms play in mediating that process. Drawing on 12 semi-structured interviews with vegan participants across 4 groups defined by age and length of vegan practice – New Sprouts, Early Roots, Late Bloomers, and The Oakes – the study traces the specific processes thr
Enligt prospect theory (Kahneman & Tversky, 1979) utvärderas utfall som vinster och förluster i relation till en referenspunkt, vilket ger upphov till systematiska mönster i beslutsfattande under osäkerhet, inklusive certainty effect och reflection effect. Samtidigt kan individuella skillnader i riskbenägenhet också påverka ekonomiska val, eftersom högre finansiell riskbenägenhet är associeradAccording to prospect theory (Kahneman & Tversky, 1979), outcomes are evaluated as gains and losses relative to a reference point, giving rise to systematic patterns of decision-making under uncertainty, including the certainty effect and reflection effect. Yet, individual differences in risk propensity may also influence economic choice, as higher financial risk propensity is associated with
Urban pluvial flooding threatens transport accessibility, yet the spatial factors such as elevation, vegetation, and road density associated with accessibility loss remain insufficiently understood. This study assessed changes in nearest-facility travel time to hospitals, clinics, schools, supermarkets, and fire stations under a 100-year return period flood scenario in Stockholm, Sweden, for both
Protein recovery from fermentation broths remains a challenge in downstream bioprocessing due to the complex composition of fermentation media. This study investigated a cascade microfiltration–ultrafiltration (MF–UF) process for protein clarification and concentration from a whey protein-based model fermentation broth. The work evaluated membrane performance, fouling behavior, cleaning efficiency
This article examines why some economies sustain large financial sectors without experiencing the negative effects on economic performance predicted by the finance-threshold literature. It analyzes South Korea and Taiwan during their economic transformations from the 1960s to early 2000s, combining descriptive statistics on financial depth (private credit-to-GDP) and economic shrinking (years of n
This thesis examines how middle managers construct, enact, and navigate organizational values in everyday managerial practice. While organizational values are often presented as stable principles intended to guide behavior and create cohesion, the everyday realities of managerial work are more ambiguous and relational than such representations suggest, particularly for middle managers positioned b
