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Postnatal constriction of the full-term ductus arteriosus produces cell death and remodeling of the ductus wall. Using a bioluminescence imaging technique, we found that after birth, the lamb ductus develops ATP, glucose, and glycogen depletion in addition to hypoxia. In vitro studies showed that cell death correlates best with ATP depletion and is most marked when both glucose and oxygen are seve
Exposure to exogenous (oral contraceptives, postmenopausal hormone therapy) and endogenous (number of ovulatory cycles, adiposity) steroid hormones is associated with breast cancer risk. Breast cancer risk associated with these exposures could hypothetically be modified by genes in the steroid hormone synthesis, metabolism and signaling pathways. Estrogen receptors are the first step along the pat
Medullomyoblastoma (MMB) is a rare cerebellar childhood tumor containing both myoblastic and primitive neuroectodermal components. Similar to the scenario in classical medulloblastoma, which contains the primitive neuroectodermal component only, gain of sequences from the long arm of chromosome 17 (17q) and gain of the MYC gene in 8q have been implicated in the pathogenesis of MMB. Because karyoty
Review of Tadhg O’Keeffe, “Archaeology and the Pan-European Romanesque” (London 2007).
Combined quantum chemical and molecular mechanics geometry optimisations have been performed on myoglobin without or with O(2) or CO bound to the haem group. The results show that the distal histidine residue is protonated on the N(varepsilon2) atom and forms a hydrogen bond to the haem ligand both in the O(2) and the CO complexes. We have also re-refined the crystal structure of CO-myoglobin by a
We study the concept of self-similarity with respect to stochastic time change. The negative binomial process (NBP) is an example of a family of random time transformations with respect to which stochastic self-similarity holds for certain stochastic processes. These processes include gamma process, geometric stable processes, Laplace motion, and fractional Laplace motion. We derive invariance pro
The currant shoot borer, Lampronia capitella (Lep., Prodoxidae), is an important pest of currants, Ribes spp., in northern Europe. Oviposition was studied in cage experiments and the flight period was monitored in field studies using pheromone-baited traps. Blackcurrant, Ribes nigrum, was the host species in both studies. The total egg supply of females was on average 107 eggs and oviposition star
Sweden's decision to choose neutrality as its security policy orientation in the first half of the nineteenth century is explained with the help of image theory. It is argued that a theory focusing on the images of policy-makers regarding self, others and situation provides a better explanation of these strategic decisions than traditional balance-of-power theories. The important role of enemy-ima
Human liver alpha-L-fucosidase (alpha-L-fucoside fucohydrolase, EC 3.2.1.51) has been separated into four components by chromatography on Sephadex G-150 or DEAE-cellulose. These components differ in their relative stability to heat and acid treatment, and their response to neuraminidase. The serum enzyme was devoid of high molecular weight activity and probably contained more sialic acid residues
This article traces the reception of the the Swedish film Ingeborg Holm in 1913. The film created a fierce debate regarding the Swedish poor laws. This debate eventually led to changes in the law in 1918.
Childhood conduct disorder (CD) and adult psychopathic traits according to the Psychopathy Checklist Revised (PCL-R) were the closest psychiatric covariates to repeated violent crimes and aggression among offenders under forensic psychiatric investigation in Sweden. As psychopathy is not included in the present psychiatric diagnostic systems, we compared total and factor PCL-R scores to Axis I dis
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Popular Abstract in Swedish Våra vita blodceller bildas i benmärgen och när de mognat färdigt hamnar de i blodcirkulationen. Det finns olika typer av vita blodceller och varje typ har sin egen funktion. En speciell typ av vit blodcell, nämligen den myeloida vita blodcellen (neutrofilen), spelar en mycket viktig roll i kroppens första försvar mot invaderande bakterier. När bakterier kommer in i kroIn myelopoiesis, neutrophils and monocytes/macrophages are formed from a common myeloid precursor cell in the bone marow. During maturation of neutrophils, cytoplasmic granules are formed in the cells and the content of these granules is critical for the function of neutrophils in the first line of defense against invading microorganisms. The Bactericidal/Permeability-Increasing protein (BPI) is s
Purpose: Cystatin C is a mammalian cysteine protease inhibitor. This study describes the localization of cystatin C in the anterior segment of normal rat and mouse eyes. Cysteine proteases play an important role in protein degradation (e.g. of photoreceptor outer segments in the retinal pigment epithelium) and the balance between these proteases and their specific inhibitors is therefore of great
The International Congresses have played an important role in the history of genetics. The Eighth International Congress, which in 1948 was held in Sweden, celebrated the conclusion of the war against Nazism and many new decisive scientific advances. It also signaled a hardening of the fight against Lysenkoism, which was growing in strength in the Soviet Union. A rare document is available from th
On 15 March 2012, Felix Baumgartner jumped from 71 500 feet [1], a test jump as part of his attempt to beat the earlier record set by Joe Kittinger, who jumped from 102 800 feet in 1960, as part of the US space programme [2] The ascent to these elevations in a helium balloon, followed by free fall, with varying temperatures and speed of sound, and increasing air resistance and density, can lead te
