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Prevention and control of infectious diseases is seriously hampered by an increasing prevalence of bacteria that are resistant towards conventional antibiotics. Resistant bacteria are often the root cause of infections that trigger the complex clinical syndrome called sepsis, which is a concern for high morbidity and mortality. Despite extensive basic research and clinical studies, treatment of se
Prostate cancer (PC) develops from an androgen-dependent tissue that contains androgen receptors in both the stromal and glandular compartments. Surgical removal of the prostate may cure the patient, but if metastatic spread has occurred, androgen suppression therapy is the standard treatment. However, most men will eventually fail this therapy and develop recurrent androgen-independent disease, f
Intractable conflicts are by definition difficult to resolve. This study ventures into the identity dynamics of those conflicts and argues that those identity aspects must be addressed in order to locate constituencies for change. Through the employment o theories of conflict transformation, identity and narrative, the dissertation forwards thoughts regarding the importance of inside actors formul
Popular Abstract in Swedish Parkinsons sjukdom är en av våra mest förekommande neurologiska sjukdomar som drabbar den åldrande befolkningen. I åldersgruppen 50-60 år drabbas ca 1 procent av sjukdomen, som karakteriseras av de motoriska symptomen stelhet, långsamma rörelser och skakningar. Symptomen beror på en gradvis förlust av nervceller i en djup del av hjärnan vid namn substantia nigra (den svL-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. The causes behind dyskinesia are not completely understood, but intense research has identified a number of neuronal alterations associated with L-DOPA-induced dyski
The participation of transnational actors in global policymaking is increasingly seen as a means to democratize global governance. Drawing on alternative theories of democracy and existing empirical evidence, we assess the promises and pitfalls of this vision. We explore how the structuring and operation of international institutions, public-private partnerships, and transnational actors themselve
In this paper we derive a very useful formula for the stochastic representation of the product of a singular Wishart matrix with a normal vector. Using this result, the expressions of the density function as well as of the characteristic function are established. Moreover, the derived stochastic representation is used to generate random samples from product which leads to a considerable improvemen
The use of gluten-free products is increasing since an increasing number of people (1-2 %) are suffering from Celiac disease and thereby need a gluten-free diet. Gluten-free bread tends to have shorter shelf life and quality compared with white wheat bread. In this study, 3 % (flour basis) of pre-gelatinized oat and barley flour as well as an emulsifier were added to a gluten-free mix to increase
The geometric and electronic structure of condensed phase organic conducting polymer PEDOT:PSS blends has been investigated by periodic density functional theory (DFT) calculations with a generalized-gradient approximation (GGA) functional, and a plane wave basis set. The influence of the degree of doping of the PEDOT polymer on structural and optical parameters such as the reflectivity, absorbanc
This article proceeds from a conceptual analysis of how ontological (in)security is constructed in terms of ‘security-of-being’ in which identity dynamics are explicated in socio-psychological terms. Of particular interest is how such dynamics transcend the boundaries of individual self/other constructions to define communities and states, and how these dynamics are transformed in times of trauma
The dynamic properties of the glomerular filtration barrier (GFB) are of fundamental importance for the understanding of the physiology and pathophysiology of microalbuminuria and proteinuric diseases. In the studies of this doctoral thesis the properties of the rat glomerular filtration barrier were investigated under resting conditions and following a number of challenges using highly sensitive
TRPA1 is a unique sensor of noxious stimuli and, hence, a potential drug target for analgesics. Here we show that the antinociceptive effects of spinal and systemic administration of acetaminophen (paracetamol) are lost in Trpa1(-/-) mice. The electrophilic metabolites N-acetyl-p-benzoquinoneimine and p-benzoquinone, but not acetaminophen itself, activate mouse and human TRPA1. These metabolites a
Abstract Multimodal learning materials are frequently met in education assuming enhanced learning outcomes. This study examined whether contrasts in such materials are likely to support reading comprehension for all readers. Young adults (n=46) met either text-only or text+picture material. Participants (19 with low phonological awareness [PA] and 27 controls with high PA) thereafter answered open
OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral g
My PhD submission is made up of a constellation of three elements that form a body of textual material / theory and practice event / exhibition. (1) A dimension of critical writing or dissertation that has two parts: (a) Retrospective / Prospective: Activating the Archive, September 1, 2010, and (b) an accretion of further analysis, Archive, Archived, Archiving, September 1, 2011. (2) A testin
The antigens in the P1PK blood group system are carried on glycosphingolipids. The system currently includes three different antigens, P1, Pk, and NOR. The P1 antigen was disovered in 1927 by Landsteiner and Levine, and Pk and NOR were described in 1951 and 1982, respectively. As in the ABO system, naturally occurring antibodies of the immunoglobulin (Ig) M or IgG class, against the missing carboh
During the last 35 years almost 5000 ceramic thin-sections have been analysed at the Laboratory for Ceramic Research, Lund University and of those have 1650 analyses been performed on material from the Iron Age in Northern Europe (here c. 500 BC-1100 AD). Currently there is a project to register these analyses in a database and evaluate the results. We can for the first time get an overall picture
High-resolution palaeoecological proxies of pollen, macrofossils and diatoms from an isolation lake provide a long-term record of the Holocene landscape history and shoreline displacement on the Biskopsmala Peninsula in central Blekinge, SE Sweden. During the Preboreal/Boreal transition, the peninsula was sparsely vegetated by woodlands, along with lateglacial dwarf shrub/steppe communities. The l
