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Tumour-induced osteomalacia is caused by tumorous production of fibroblast growth factor 23 (FGF23) leading to urinary phosphate wasting, hypophosphataemia and decreased vitamin D activation. The resulting osteomalacia presents with muscle weakness and bone pain but progresses to multiple pathological fractures. Patients often remain undiagnosed for years with severe physical, psychological and ec
Protein aggregation is a key process in the development of many neurodegenerative disorders, including dementias such as Alzheimer's disease. Significant progress has been made in understanding the molecular mechanisms of aggregate formation in pure buffer systems, much of which was enabled by the development of integrated rate laws that allowed for mechanistic analysis of aggregation kinetics. Ho
Recent studies have explored the influence of obesity and critical illness on ciprofloxacin pharmacokinetics. However, variation across the subpopulation of individuals with obesity admitted to the intensive care unit (ICU) with varying renal function remains unexamined. This study aims to characterize ciprofloxacin pharmacokinetics in ICU patients with obesity and provide dose recommendations for
Objective: To translate and cross-culturally adapt the Stroke Self-Efficacy Questionnaire (SSEQ) from English to Swedish and to evaluate psychometric properties of the questionnaire. Methods: A cross-sectional study design, where the translation followed a process including initial translation, synthesis, backward translation, expert committee, and pretest. Content validity was assessed using Cont
Digitalization and emergence of new technologies including Artificial Intelligence has shaped new organizational principles for the functioning of economies and societies globally. Technology has also changed the landscape for taxation and interactions between tax administration and taxpayers. Recently various models of electronic reporting and invoicing, split-payment mechanisms as well electroni
Taking point of departure in two black dolls that once belonged to Sophie Christine Oxholm and to the family of Clara Asenath Schultz, the article explores aspects of childhood and childcare in colonial homes. Both girls grew up in the Danish West Indies in the nineteenth century and were cared for by African Caribbean nannies – the likely makers of the dolls. Drawing on historical and literary so
This article examines limits to per capita living space (i.e. living smaller and/or sharing living space) as a measure for achieving sufficiency in housing. It studies the acceptance, motivation and side-effects of voluntarily reducing living space in five European Union countries: Germany, Hungary, Latvia, Spain and Sweden. Insights are derived from an extensive collection of qualitative empirica
This chapter argues against the claim that morally ignorant wrongdoers are open to blame only if they are culpable for their ignorance, and argues against a version of skepticism about moral responsibility that depends on this claim being true. On the view defended, the attitudes involved in blame are typically responses to the features of an action that make it objectionable or unjustifiable from
We present a general method, the δ-test, which establishes functional dependencies given a sequence of measurements. The approach is based on calculating conditional probabilities from vector component distances. Imposing the requirement of continuity of the underlying function, the obtained values of the conditional probabilities carry information on the embedding dimension and variable dependenc
The spread of pathogens between individuals has important effects on patterns of mortality, behaviour and the genetic structure of populations. One factor that is predicted to influence the transmission of pathogens is the genetic diversity of the host group. Groups of closely related individuals are susceptible to similar pathogens, and hence increase in genetic diversity of the group should decr
Background Axis is a network surveillance company, based in Lund, Sweden. Axis has outsourced its production to contract manufacturers which are positioned in different parts of the world. Axis’ suppliers are also spread across the globe. During the last years, Axis has experienced several supply disruptions from its suppliers and contract manufacturers, due to natural and technological disasters.
Liposomes are closed spherical bilayered membrane structures in aqueous solutions, with an internal aqueous compartment entrapped by either a single or multiple concentric lipid bilayer(s). They can be used as a tool in research to mimic simple cell membranes, to study e.g. lipid-protein interactions, as well as they are extensively used as carriers of various molecules, especially for tumor targe
The bacteriophage vB_YecM-φR1-37 (φR1-37) is a lytic yersiniophage that can propagate naturally in different Yersinia species carrying the correct lipopolysaccharide receptor. This large-tailed phage has deoxyuridine (dU) instead of thymidine in its DNA. In this study, we determined the genomic sequence of phage φR1-37, mapped parts of the phage transcriptome, characterized the phage particle prot
