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BackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under

Mot smartare cellgiftsbehandling: Att förebygga behandlingsresistens vid äggstockscancer Äggstockscancer är den dödligaste gynekologiska cancertypen och kräver alltför många liv eftersom tumörer ofta blir resistenta mot behandling – särskilt mot cisplatin, vårt främsta försvar. För att rädda fler liv måste vi förstå hur denna resistens utvecklas och hur vi kan överlista den. I mitt examensarbete Ovarian cancer is the deadliest gynaecologic malignancy, with most patients diagnosed at an advanced stage and facing poor long-term survival. Resistance to cisplatin-based chemotherapy is a major clinical obstacle, yet its proteomic drivers remain poorly defined. In this study, I applied data-independent acquisition mass spectrometry with DIA-NN data processing to analyse one parental and two cis

Aim: Grass-yellow butterflies (Eurema) are a group of pantropical Pieridae distributed throughout Asia, Australasia, Africa and the New World. However, little is known about their diversification, including the biogeographic mechanism(s) explaining their circumglobal distribution. We present the first densely sampled, time-calibrated phylogeny and biogeographic reconstruction of grass-yellows to c

In this paper, design and measurements of a fully integrated power amplifier (PA) are presented. The PA consists of two amplifying chains each having a driver and a power stage. A low loss on chip power combiner combines the outputs from two amplifying chains, and also performs impedance transformation and differential to single-ended conversion. To linearize the PA, the driver stage is biased in

BackgroundA novel non-invasive method for generation of pressure volume loops (PV-loops) using brachial blood pressure and cardiovascular magnetic resonance (CMR) imaging has recently been presented and validated (1). The non-invasive nature of this method enables calculation of PV-loops in large patient cohorts previously not feasible due to the need of invasive measurements.PurposeThe purpose of

Massive multiple-input multiple-output (MIMO) systems, where the base station (BS) is equipped with a large number of antennas and the mobile devices have a single antenna, can significantly enhance the system performance. In many wireless systems inter symbol interference (ISI) due to delay dispersion of the channel can dramatically affect the demodulation process of the received signals. Precodi

Abstract in UndeterminedVery large MIMO is a technique that potentially can offer large network capacities in multi-user scenarios where the users are equipped only with single antennas. In this paper we are investigating channel properties for a realistic, though somewhat extreme, outdoor base station scenario using a large array. We present measurement results using a 128 element linear array ba