Filetype
The role of the carbohydrates for the structure and functions of the plasma and tissue protein alpha1-microglobulin (alpha1m) was investigated by deletion of the sites for N-glycosylation by site-directed mutagenesis (N17,96-->Q). The mutated cDNA was expressed in a baculovirus-insect cell system resulting in a nonglycosylated protein. The biochemical properties of N17,96Q-alpha1m were compared to
Populärvetenskaplig sammanfattning De båda polerna har naturliga variationer med istäckets utbredning. Arktis och Antarktis har väl anpassad biota som klarar av det stränga klimatet och som är beroende av isens säsongsvariationer med att frysa och smälta. Isen spelar även en stor roll vid klimatvariationer och förändringar. Syftet med den här studien är att undersöka vilken isbildning som är mest The polar areas have natural variations in the ice extent. The Arctic and Antarctic environment have well-adapted biota that can handle climate and that are dependent on the seasonal variations of freezing and melting of the ice. The ice also plays a major role in climate changes and climate variability. The aim of this report is to determine the type of ice formation that is most common for the p
Gaucher disease type 1 (GD type 1) and Diamond-Blackfan anemia (DBA) are rare genetic disorders affecting the hematopoietic system and routinely treated by administration of drugs with variable clinical efficacy. Though effective in alleviating disease symptoms in large cohorts of patients, these treatment options have the major drawback of being non-curative. Currently, bone marrow transplantatio
With the vast processes of digitalization and digitization taking place in many countries in the world, the small northeastern European country Estonia has managed to make incredible advancements in the field of technology and in creating a digital society. Today, the most digitized country and government in the world provides a vast majority of governmental services online, presents the most unic
We present evidence of a submerged early Holocene landscape off the Blekinge coastline in the Baltic Sea, dating to the Yoldia Sea and Initial Littorina Sea Stages when the water level was lower than at present. 14C dated wood remains obtained by surveillance diving and new archaeological findings in combination with bathymetric analyses and interpolations between other sites across the Baltic Sea
Heritage buildings are usually culturally protected as well as naturally ventilated. As such, it is difficult to control the airflow, which depends on the temperature outdoors as well as the wind. This causes issues with the thermal comfort and the indoor air quality. In this study, status determinations were conducted for 12 heritage buildings with offices, across Sweden. Field measurements on te
Program/Project Purpose: Increased recognition of the global cancer burden and inequalities in care and outcomes have led to the growing field of global oncology, focused on strengthening health systems to improve cancer prevention and care. Motivated students and trainees are in need of pathways to approach these challenges. In 2012, Harvard Medical students formed Students for Global Oncology (S
“The definition of insanity is doing the same thing over and over again but expecting different results.” This quote by Albert Einstein highlights our need for new formats of communication to address the knowledge-action gap regarding climate change and other sustainability challenges. This includes reflection, and communication spaces, as well as methods and approaches that can catalyze the emerg
The authors used the Swedish Family-Cancer Database to search for evidence for a genetic predisposition in lung cancer. Familial risks in offspring were increased for all lung cancer to 1.77 when a parent was affected with any lung cancers; the comparable risk among siblings was 2.15. At young age, risks between siblings were higher than those between offspring and parents for all histological typ
Purpose:The article makes an empirical and conceptual contribution to understanding the temporalities of information literacies. The paper aims to identify different ways in which anticipation of certain outcomes shapes strategies and tactics for engagement with algorithmic information intermediaries. The paper suggeststhat, given the dominance of predictive algorithms in society, information lite
Background: Parkinson's disease (PD) is a progressive neurodegenerative disease with motor- and non-motor symptoms. When the disease progresses, symptom burden increases. Consequently, additional care demands develop, the complexity of treatment increases, and the patient's quality of life is progressively threatened. To address these challenges, there is growing awareness of the potential benefit
Infantile malignant osteopetrosis is a devastating disorder of early childhood that is frequently fatal and for which there are only limited therapeutic options. Gene therapy utilizing autologous hematopoietic stem and progenitor cells represents a potentially advantageous therapeutic alternative for this multisystemic disease. Gene therapy can be performed relatively rapidly following diagnosis,
Performance-based, service-life design of wood has been the focus of much research in recent decades. Previous works have been synthesized in various factorized design frameworks presented in the form of technical reports. Factorization does not consider the non-linear dependency between decay-influencing effects, such as between detail design and climate variables. The CLICKdesign project is a jo
Dagens samhälle präglas av globalisering och gränsöverskridande handel. I vår del av världen verkar EU och den fria rörligheten som inte bara ger människor och företag rättigheter utan även påverkar våra skatter. I centrum för handeln återfinns företagen, stora som små, som vågar ta klivet över till andra marknader för att se om de klarar av konkurrensen och på sikt öka vinsten då nya marknader inToday’s society is globalised with international trade as a consequence. In our part of the world the EU with it’s advantages and disadvantages concerning the free movement of capital, people and business affects us all, but also our taxes. Companies, big and small are in the centre of the cross-border trade with their expansion into new markets. Business adventures of this kind can generate incre
In the face of climate change wind energy plays an increasing role in Norway. The construction of new wind farms causes opposition and conflicts with, among others, Sámi reindeer herders who are concerned about losing their pastures. By using Schlosberg’s (2004) environmental justice framework, I explore the justice implications of wind energy with regard to Sámi reindeer husbandry in the case of
In the field of molecular biology, the cloning of DNA is a vital process. Through cloning, researchers can design new DNA strands which can be used for a number of applications. One of these applications is the creation of synthetic antibodies for cancer treatments. Alligator Bioscience is developing a high-throughput chain to significantly speed up the process. Traditional cloning techniques rely
The Taranta1 project, a collaboration between the MAX IV Institute1 and Square Kilometre Array (SKAO)2 within the Tango3 Collaboration, presents a web-based, no-code approach for creating graphical interfaces dedicated to monitoring and controlling Tango-based systems. Through an active development phase and close collaboration with the community, the software has seen the introduction of advanced
We present a fully automated generative method for simultaneous brain tumor and organs-at-risk segmentation in multi-modal magnetic resonance images. The method combines an existing whole-brain segmentation technique with a spatial tumor prior, which uses convolutional restricted Boltzmann machines to model tumor shape. The method is not tuned to any specific imaging protocol and can simultaneousl
Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families Genetic Contribution to the Divergence in Type 1 Diabetes Risk Between Children From the General Population and Children From Affected Families Markus Hippich,1 Andreas Beyerlein,1,2 William A. Hagopian,3 Jeffrey P. Krischer,4 Kendra Vehik,4 Jan Knoop,1 Ch
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-12/103%2005072019_679_103_MP162_Hippich_Diabetes_2019.pdf - 2026-06-27
