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Two phase ii randomized trials on the CRTh2 antagonist AZD1981 in adults with asthma

Background: Chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cell (CRTh2) receptor antagonists is being investigated for asthma. Objectives: The aim of this study was to assess the effects of the CRTh2 receptor antagonist, AZD1981 (with/without inhaled corticosteroids [ICSs]), on lung function and asthma control. Patients and methods: Adults aged 18–60 years were enr

Sugar-sweetened beverage consumption and genetic predisposition to obesity in 2 Swedish cohorts

Background: The consumption of sugar-sweetened beverages (SSBs), which has increased substantially during the last decades, has been associated with obesity and weight gain. Objective: Common genetic susceptibility to obesity has been shown to modify the association between SSB intake and obesity risk in 3 prospective cohorts from the United States. We aimed to replicate these findings in 2 large

Pairing Wikipedia Articles Across Languages

Wikipedia has become a reference knowledge source for scores of NLP applications. One of its invaluable features lies in its multilingual nature, where articles on a same entity or concept can have from one to more than 200 different versions. The interlinking of language versions in Wikipedia has undergone a major renewal with the advent of Wikidata, a unified scheme to identify entities and their

Smooth pursuit detection in binocular eye-tracking data with automatic video-based performance evaluation

An increasing number of researchers record binocular eye-tracking signals from participants viewing moving stimuli, but the majority of event-detection algorithms are monocular and do not consider smooth pursuit movements. The purposes of the present study are to develop an algorithm that discriminates between fixations and smooth pursuit movements in binocular eye-tracking signals and to evaluate

Acyl migration in enzymatic interesterification of triacylglycerols : Effects of lipases from Thermomyces lanuginosus and Rhizopus oryzae, support material, and water activity

The enzymatic interesterification of a solvent-free, equimolar mixture of trilaurin and 1,3-palmitin-2-olein was studied using three immobilized lipase preparations as catalysts. Analysis of triacylglycerol (TAG) content and fatty acid (FA) distribution monitored the lipase-catalyzed interesterification in sn-1,3 positions and FA exchange in the sn-2 position caused by acyl migration. Lipase from

The role of the amygdala during emotional processing in Huntington's disease : from pre-manifest to late stage disease

BACKGROUND: Deficits in emotional processing can be detected in the pre-manifest stage of Huntington's disease and negative emotion recognition has been identified as a predictor of clinical diagnosis. The underlying neuropathological correlates of such deficits are typically established using correlative structural MRI studies. This approach does not take into consideration the impact of disrupti

Association between age, gender and multimorbidity level and receiving home health care : a population-based Swedish study

BACKGROUND: Home health care is an important part of primary health care. How delivery of home health care is organised is probably important for sustainability of the healthcare system as a whole. More than 50 % of individuals over 65 years old have multimorbidity, which increases with higher age, also influencing the needs of home health care. Our aim was to study the proportion of the populatio

One-year postpartum anthropometric outcomes in mothers and children in the LIFE-Moms lifestyle intervention clinical trials

Background/objectives: Excess gestational weight gain (GWG) is a risk factor for maternal postpartum weight retention and excessive neonatal adiposity, especially in women with overweight or obesity. Whether lifestyle interventions to reduce excess GWG also reduce 12-month maternal postpartum weight retention and infant weight-for-length z score is unknown. Randomized controlled trials from the LI

Early repair of trauma-related full-thickness rotator cuff tears does not eliminate the problem of healing failure

AIMS: Failure of healing is a well-known problem after repair of the rotator cuff. This study aimed to investigate if early repair of trauma-related full-thickness rotator cuff tears (FTRCTs) could prevent this failure. PATIENTS AND METHODS: In this prospective trial, 62 consecutive patients (14 women (23%), 48 men (77%); median age 61 years (interquartile range (IQR) 54 to 65)) with trauma-relate

ABO blood type and risk of porcine bioprosthetic aortic valve degeneration : SWEDEHEART observational cohort study

Objective Blood type A antigen on porcine aortic bioprostheses might initiate an immune reaction leading to an increased frequency of structural valve deterioration in patients with blood type B or O. The aim was to analyse the association between ABO blood type and porcine bioprosthetic aortic valve degeneration. Design Observational nationwide cohort study. Setting Swedish population-based study

TFAP2B influences the effect of dietary fat on weight loss under energy restriction

Background: Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. Methods and Findings: Randomized controlled trial of 771 obese adults. (Registration: ISRCTN25867281.) One SNP was selected for replication i

On exposure to anorexia nervosa, the temporal variation in axial and appendicular skeletal development predisposes to site-specific deficits in bone size and density : A cross-sectional study

Skeletal development is heterogeneous. Throughout growth, bone size is more maturationally advanced than the mineral being accrued within its periosteal envelope; before puberty, appendicular growth is more rapid than axial growth; during puberty, appendicular growth slows and axial growth accelerates. We studied women with differing age of onset of anorexia nervosa to determine whether this tempo

Coping facilitated troponin T increases and hypo-responsivity in the copeptin-HPA-axis during acute mental stress in a Black cohort : The SABPA study

BACKGROUND: Defensive coping (DefS) was associated with a vulnerable cardiovascular profile in Blacks. The copeptin/vasopressin system is a manifestation of hypothalamic-pituitary-adrenal-axis activity and may act as an acute compensatory mechanism when there is a disruption in volume-loading homeostasis, i.e. when cardiac stress is evident. Whether DefS will influence associations between copepti

Relationship between herd-level incidence rate of energy-related postpartum diseases, general risk factors and claw lesions in individual dairy cows recorded at maintenance claw trimming.

Laminitis and energy-related postpartum diseases share several risk factors, indicating a common etiology. Thus, a herd's incidence rate of energy-related postpartum diseases, such as displaced abomasum and clinical ketosis, might reflect the likelihood of cows to suffer from laminitis-related claw lesions. The aim of this study was to investigate the association between herd-level incidence rate

Activated protein C-protein C inhibitor complex: a new biological marker for aortic aneurysms.

Objective: The concentration of the complex between activated protein C (APC) and protein C inhibitor (PCI) is a measure of thrombin generation. We studied whether it can provide information useful for the diagnosis and treatment of arterial vascular disease. Methods: Blood was obtained from 429 vascular patients admitted consecutively during September 2004 to March 2005. The APC-PCI complex was m

Konturer av ett kvinnligt fält : Om missbrukande kvinnors möten i familjeliv och behandling

Popular Abstract in Swedish Missbrukande kvinnor och mammor har ofta fördömts av samhället och av människor i sin omgivning. De har setts som ansvarslösa kvinnor och olämpliga mammor utifrån en samhällssyn, att barn och missbruk inte går ihop. De livshistoriska intervjuerna med missbrukande kvinnor och mammor, som avhandlingen bygger på visar, att kvinnorna både vill vara respektabla och ta väl haThe aim of the dissertation is to describe the conditions under which substance abusing women live with regard to their families, the substance abuse and treatment. The interaction between the substance abusing women and the institutional expectations is analysed from gender and class perspective. The dissertation is based on interviews with two groups of substance abusing women: 12 mothers, livin